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      • KCI등재

        Conversion of calcite from cockle shells to bioactive nanorod hydroxyapatite for biomedical applications

        Nur Ain Iftitah Mohamad Razali,Sumit Pramanik,Noor Azuan Abu Osman,Zamri Radzi,Belinda Pingguan-Murphy 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.7

        Bioactive ceramics such as hydroxyapatite (HA) can mimic the organic structure of human bone. HA was successfullysynthesized from animal bones, corals, and eggshells which have been studied for bone repairing treatment and as implantcoatings. This study aims to synthesize nanorod HA from cockle shells via two routes: calcination and the hydrothermalmethod. The raw cockle shells were converted to calcite by calcination method at 450 oC (CS450) and 800 oC (CS800) for 2 hrs. The calcite calcium carbonate samples were reacted with diammonium hydrogen phosphate and hydrothermally treated at110 oC. The pH of the solution was kept at 10.5 throughout the synthesis step by adding drops of ammonia. Product obtainedwas labelled as HA450 and HA800 containing HA powder. Presence of calcite phase in the raw cockle shells was characterizedby utilizing Thermogravimetric analysis (TGA), X-ray Diffraction (XRD) and Fourier transforms infrared spectrophotometer(FTIR) analyses and morphologically analyzed by Field emission scanning electron microscopy (FESEM). The best result wasobtained from the HA800 sample where nanoparticle with rod-like shape was observed (aspect ratio = 7) while needle-likeparticle was seen in HA450 sample (aspect ratio = 20). High purity HA was developed in HA800 sample while HA450 showedsmall presence of calcite phase. In vitro bioactivity test of HA powder samples incubated simulated body fluid (SBF) for 1, 3,8, 15 and 21 days showed high bioactivity in both samples by forming apatite agglomerate on the surfaces. Highermicrohardness strength was observed in HA800 compared to HA450, CS450 and CS800 sintered pellet samples.

      • Adjunctive buccal and palatal corticotomy for adult maxillary expansion in an animal model

        My Huy Thuc Le,Seng Fong Lau,Norliza Ibrahim,Abu Kasim Noor Hayaty,Zamri Bin Radzi 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.2

        Objective: This study aimed to explore the usefulness of adjunctive buccal and palatal corticotomy for adult maxillary expansion in an animal model using cone-beam computed tomography (CBCT). Methods: Twelve adult sheep were randomly divided into two groups (each n = 6): a control group, where no treatment was administered, and a treatment group, where buccal and palatal corticotomy-assisted maxillary expansion was performed. CBCT scans were taken before (T1) and after (T2) treatment. Differences in all transverse dental and alveolar dimensions, alveolar width at crest level, hard palate level, horizontal bone loss, interdental cusp width and inter-root apex were assessed using Wilcoxon signed-rank and Mann–Whitney U-tests. Kruskal–Wallis tests and pairwise comparisons were used to detect the significance of differences among the inter-premolar and inter-molar widths. Results: CBCT data revealed significant changes in all transverse dental and alveolar dimensions. The mean interpremolar alveolar width showed an increase of 2.29 to 3.62 mm at the hard palate level, 3.89 to 4.38 mm at the alveolar crest level, and 9.17 to 10.42 mm at the buccal cusp level. Dental changes in the vertical dimension were not significant. Conclusions: Our findings based on an adult animal model suggest that adjunctive buccal and palatal corticotomy can allow for both skeletal and dental expansion, with the amount of dental expansion exceeding that of skeletal expansion at alveolar crest and hard palate levels by two and three folds, respectively. Therefore, this treatment modality is potential to enhance the outcomes of maxillary expansion in adults.

      • KCI등재

        Alveolar restoration following rapid maxillary expansion with and without corticotomy: A microcomputed tomography study in sheep

        My Huy Thuc Le,Abu Kasim Noor Hayaty,Zuraiza Mohamad Zaini,Sulaiman Md Dom,Norliza Ibrahim,Zamri Bin Radzi 대한치과교정학회 2019 대한치과교정학회지 Vol.49 No.4

        Objective: This study examined bone microstructure restoration after rapid maxillary expansion (RME) with and without corticotomy over multiple retention periods. Methods: Eighteen male Dorper sheep were randomly distributed into three groups (n = 6 each group): group 1, RME with corticotomy on the buccal and palatal sides; group 2, conventional RME treatment; and group 3, no treatment. Post-RME, trabecular bone microstructure and new bone formation were evaluated by using microcomputed tomography (microCT) and histomorphometry after a 4- or 12-week retention period. Intergroup differences in bone quality and bone remodeling were analyzed by using two-way analysis of variance with Bonferroni post-hoc test. Results: The bone volume fraction (bone volume [BV]/total volume [TV]) values relative to the control in groups 1 and 2 were 54.40% to 69.88% after the 4-week retention period and returned to approximately 80% after the 12-week retention period. The pooled BV/ TV values of the banded teeth in groups 1 and 2 were significantly lower than those of the control after the 4-week retention period (p < 0.05). However, after the 12-week retention period, the pooled BV/TV values in group 2 were significantly lower than those in groups 1 and 3 (p < 0.05). Histomorphological analysis showed that the new bone formation area in group 1 was approximately two to three times of those in group 2 and control. Conclusions: Corticotomy significantly enhanced the restoration of bone quality after the retention periods for banded teeth. This benefit might result from the increased new bone formation after corticotomy.

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