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Development and Stability Evaluation of Enteric Coated Diclofenac Sodium Tablets Using AquaPolish E.
( Zaid A. N. ),( Fadda A. M. ),( Nator S. ),( Qaddumi A. ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.4
The aim of this study was to develop a stable enteric coated diclofenac sodium (DFS) tablets using Aqua- Polish E without using a subcoat. DFS uncoated tablets were manufactured through the non direct compression process. AquaPolish E white aqueous coating dispersion was used as enteric coating material. This film forming polymer is a mixture of selected polymethacrylic/ethylacrylate copolymers. The stability of the obtained enteric coated tablets was evaluated according to ICH guidelines. No signs of disintegration or cracking was observed when they placed in 0.1N HCl solution (pH1.2), but they were completely disintegrated within 10 minutes when they placed in buffered solution at pH6.8. Dissolution test was also conducted by placing tablets in 0.1 N HCl for 2 hours and then 1 hour in phosphate buffer at pH 6.8. Less than 0.9 % of drug was released in the acidic phase and up to 97% in the basic medium. These findings suggest that aqueous enteric coating with AquaPolish E system is an easy and economical approach for preparing stable DFS enteric coat without the use of a subcoating layer.
Úrsula R. Zaidan,Larissa M. Motta,Wendel M. de Souza,Rodrigo M. Faria,Maria C. G. Paiva,Kassio F. Mendes,Francisco Cláudio L. de Freitas 한국작물학회 2021 Journal of crop science and biotechnology Vol.24 No.2
Heteranthera reniformis (mud plantain) is a weed of aquatic habit, which currently causes losses in the production of ornamental plants and irrigated crops, such as rice, and for which there are no herbicides registered in Brazil with proven control effectiveness. This study evaluated the control effectiveness of individual and multi-mixture herbicides (i.e., glyphosate, 2,4-D, triclopyr, paraquat, oxyfluorfen, sulfentrazone, carfentrazone, diuron and S-metolachor) on post-emergence of mud plantain. An organosilicone spreader adjuvant was also evaluated. Weed injury assessments were carried out over time, at 7, 14, 21, 42, and 60 days after application (DAA) of the herbicides. At the end of the study (60 DAA), the weed dry matter was measured. The progress of weed injury was modeled using a time-trend decomposition procedure based on the Locally Eighted Scatterplot Smoothing (LOESS) method. Treatments with glyphosate application proved to be more effective in relation to mud plantain injury over time, with a slight emphasis on treatments associated with triclopyr. However, evaluating the dry matter, the treatment with glyphosate alone was more effective; besides, it showed short-range injury variance in the control of H. reniformis . The inclusion of organosilicone adjuvant to some treatments was not quite successful. Regardless of the herbicide used, higher levels of initial injury are a fair predictor of fi nal control effectiveness (i.e., period after the herbicide eff ect). On the other hand, less initial injury corresponded directly to low control effectiveness. The results suggest that the herbicides, glyphosate, triclopyr, and carfentrazone, are suitable for mud-plantain control.
Léa Elias Mendes Carneiro Zaidan,Joan Manuel Rodriguez-Díaz,Daniella Carla Napoleão,Maria da Conceição Branco da Silva de Mendonça Mon,Alberto da Nova Araújo,Mohand Benachour,Valdinete Lins da Silva 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2
We examined the photocatalytic degradation of phenol from laboratory samples under UV radiation by using BiPO4/H2O2 and TiO2/H2O2 advanced oxidation systems. Both catalysts prepared were characterized by scanning electron microscopy, Fourier transform infrared and X-ray diffraction. Surface area tests showed about 3.46 and 31.33m2·g−1, respectively, for BiPO4 and TiO2. A central composite design was developed with the following variables-- catalyst concentration, time and concentration of hydrogen peroxide--to optimize the degradation process. Removal rates of 99.99% for phenol degradation using BiPO4 and TiO2 were obtained, respectively. For mineralization of organic carbon were obtained 95,56% when using BiPO4 and 63,40% for TiO2, respectively. The lumped kinetic model represented satisfactorily the degradation of phenol process, using BiPO4/H2O2/UV (R2=0.9977) and TiO2/H2O2/UV (R2=0.9701) treatments. The toxicity tests using different seed species showed the benefits of the proposed advanced oxidation process when applied to waste waters containing these pollutants.
A.H. Alamoodi,Mohammed Rashad Baker,O.S. Albahri,B.B. Zaidan,A.A. Zaidan,Wing-Kwong Wong,Salem Garfan,A.S. Albahri,Miguel A. Alonso,Ali Najm Jasim,M. J. Baqer 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.7
The COVID-19 pandemic has affected many aspects of human life. The pandemic not only caused millions of fatalities and problems but also changed public sentiment and behavior. Owing to the magnitude of this pandemic, governments worldwide adopted full lockdown measures that attracted much discussion on social media platforms. To investigate the effects of these lockdown measures, this study performed sentiment analysis and latent Dirichlet allocation topic modeling on textual data from Twitter published during the three lockdown waves in Malaysia between 2020 and 2021. Three lockdown measures were identified, the related data for the first two weeks of each lockdown were collected and analysed to understand the public sentiment. The changes between these lockdowns were identified, and the latent topics were highlighted. Most of the public sentiment focused on the first lockdown as reflected in the large number of latent topics generated during this period. The overall sentiment for each lockdown was mostly positive, followed by neutral and then negative. Topic modelling results identified staying at home, quarantine and lockdown as the main aspects of discussion for the first lockdown, whilst importance of health measures and government efforts were the main aspects for the second and third lockdowns. Governments may utilise these findings to understand public sentiment and to formulate precautionary measures that can assure the safety of their citizens and tend to their most pressing problems. These results also highlight the importance of positive messaging during difficult times, establishing digital interventions and formulating new policies to improve the reaction of the public to emergency situations.
El Ezzi, Asmahan Ali,Zaidan, Wissam Rateeb,El-Saidi, Mohammed Ahmed,Al-Ahmadieh, Nabil,Mortenson, Jeffrey Benjamin,Kuddus, Ruhul Haque Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background: The aim of the study was to investigate any associations between benign prostate hyperplasia (BPH) and single nucleotide polymorphisms (SNPs) in the VDR gene (FokI, BsmI, ApaI and Taq${\alpha}$I loci) and the CYP17 gene (MspA1I locus), as well as TA repeat polymorphism in SRD5A2 gene among Lebanese men. Materials and Methods: DNA extracted from blood of 68 subjects with confirmed BPH and 79 age-matched controls was subjected to PCR/PCR-restriction fragment length polymorphism analysis. The odds ra=tio (OR) of having a genotype and the relative risk (RR) of developing BPH for having the genotype were calculated and the alleles were designated risk-bearing or protective. Results: Our data indicated that the A and B alleles of the VDR ApaI and BsmI SNPs were highly associated with increased risk of BPH (p=0.0168 and 0.0002, respectively). Moreover, 63% of the controls compared to 43% of the subjects with BPH were homozygous for none of the risk-bearing alleles (p=0.0123) whereas 60% of the controls and 28% of the subjects with BPH were homozygous for two or more protective alleles (p<0.0001). Conclusions: For the first time, our study demonstrated that ApaI and BsmI of the VDR gene are associated with risk of BPH among Lebanese men. Our study also indicated that overall polymorphism profile of all the genes involved in prostate physiology could be a better predictor of BPH risk.
High porosity activated carbon synthesis using asphaltene particles
Rabeea Muwafaq Ayesh,Zaidan Tahseen Ali,Ayfan Abdalkareem Hamad,Younis Atyaf A. 한국탄소학회 2020 Carbon Letters Vol.30 No.2
The study aims to use asphaltene particles (As) extracted from natural bitumen to synthesize activated carbon (ACAs). The asphaltene particles were mixed with a fxed weight of potassium hydroxide (KOH) as an activating agent, preheated to 600 °C, and then treated with 15% hydrofuoric acid (HF). The methylene blue (MB) 20 mg/l was used to determine the adsorption capacity of ACAs and reactivated carbon (RACAs). The morphology of ACAs and its components were character�ized using scanning electron microscopy–energy dispersive X-ray (SEM–EDX) and Fourier-transform infrared spectroscopy (FTIR). The study included the application of adsorption isotherms Freundlich and Langmuir on the experimental data of the studied systems. The yield of ACAs was 92% of the raw material. The activated carbon displayed high adsorption capacity and can be reprocessed after reactivation using microwave radiation. The active surface area of ACAs is found to be 970 m2 /g. The efectiveness and adsorption ability of ACAs and RACAs, as proven by its adsorption capacity (218.15 and 217.907 mg/g) for MB, demonstrate that ACAs and RACAs have a large external surface area and an extensive array of pores. The ACAs are most sensitive at 30 °C and neutral pH. The results also showed that the isotherms have a good ft to the experimented data.