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Huang, H,Ryu, J,Ha, J,Chang, E-J,Kim, H J,Kim, H-M,Kitamura, T,Lee, Z H,Kim, H-H Nature Publishing Group 2006 CELL DEATH AND DIFFERENTIATION Vol.13 No.11
Osteoclast (Oc) differentiation is fundamentally controlled by receptor activator of nuclear factor kappaB ligand (RANKL). RANKL signalling targets include mitogen-activated protein kinases (MAPKs), nuclear factor kappaB (NF-κB), and nuclear factor of activated T cells (NFAT)c1. In this study, we found that p38 MAPK upstream components transforming growth factor-beta-activated kinase 1 (TAK1), MKK3, and MKK6 increased by RANKL in an early stage of osteoclastogenesis from primary bone marrow cells, which led to enhanced p38 activation. Retroviral transduction of dominant-negative (DN) forms of TAK1 and MKK6, but not that of MKK3, reduced Oc differentiation. Transduction of TAK1-DN and MKK6-DN and treatment with the p38 inhibitor SB203580 attenuated NFATc1 induction by RANKL. TAK1-DN, MKK6-DN, and SB203580, but not MKK3-DN, also suppressed RANKL stimulation of NF-κB transcription activity in a manner dependent on p65 phosphorylation on Ser-536. These results indicate that TAK1 and MKK6 constitute the p38 signalling pathway to participate to Oc differentiation by RANKL through p65 phosphorylation and NFATc1 induction, and that MKK6 and MKK3 have differential roles in osteoclastogenesis from bone marrow precursors.Cell Death and Differentiation (2006) 13, 1879–1891. doi:10.1038/sj.cdd.4401882; published online 24 February 2006
Huang, H,Kim, H J,Chang, E-J,Lee, Z H,Hwang, S J,Kim, H-M,Lee, Y,Kim, H-H Macmillan Publishers Limited 2009 CELL DEATH AND DIFFERENTIATION Vol.16 No.10
Interleukin-17 (IL-17) is a cytokine secreted primarily by T<SUB>H</SUB>-17 cells. Although IL-17 is primarily associated with the induction of tissue inflammation, the other biological roles of IL-17, including non-immune functions, have yet to be thoroughly explored. Here, we report that T-cell-produced IL-17 can induce proliferation of human bone marrow-derived mesenchymal stem cells (hMSCs) in a manner dependent on the generation of reactive oxygen species (ROS). Rac1 GTPase and NADPH oxidase 1 (Nox1) are activated by IL-17 to produce ROS, which in turn stimulates hMSC proliferation. The activation of the MEK-ERK pathway is also crucial for IL-17-dependent hMSC proliferation. TRAF6 and Act1 are required to activate Nox 1 and to phosphorylate MEK on IL-17 stimulation. Interestingly, IL-17 not only accelerates the proliferation of hMSCs, but also induces their migration, motility, and osteoblastic differentiation. Furthermore, IL-17 induces the expression of M-CSF and receptor activator of NF-κB ligand (RANKL) on hMSCs, thereby supporting osteoclastogenesis both in vivo and in vitro. On the basis of these results, we suggest that IL-17 can function as a signal to induce extensive bone turnover by regulating hMSC recruitment, proliferation, motility, and differentiation.
Structural damage detection based on residual force vector and imperialist competitive algorithm
Z.H. Ding,R.Z. Yao,J.L. Huang,M. Huang,Z. R. Lu 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.6
This paper develops a two-stage method for structural damage identification by using modal data. First, the Residual Force Vector (RFV) is introduced to detect any potentially damaged elements of structures. Second, data of the frequency domain are used to build up the objective function, and then the Imperialist Competitive Algorithm (ICA) is utilized to estimate damaged extents. ICA is a heuristic algorithm with simple structure, which is easy to be implemented and it is effective to deal with high-dimension nonlinear optimization problem. The advantages of this present method are: (1) Calculation complexity can be decreased greatly after eliminating many intact elements in the first step. (2) Robustness, ICA ensures the robustness of the proposed method. Various damaged cases and different structures are investigated in numerical simulations. From these results, anyone can point out that the present algorithm is effective and robust for structural damage identification and is also better than many other heuristic algorithms.
Experimental Study of the Runaway Current in the J-TEXT Tokamak
Y. H. Luo,Z. Y. Chen,X. Q. Zhang,D. W. Huang,W. Jin,Y. H. Huang,Y. Tang,J. C. Li,R. H. Tong,W. Yan,G. Zhuang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.3
Major plasma disruptions in tokamaks often generate runaway currents, which contain electronswith energies of several tens of megaelectron-volts (MeV). These currents can cause substantialdamage when control is lost and the current hits the limiters or the vessel wall. The interactionbetween the runaway electrons and the impurities inside the plasma results in soft X-ray emission,which can provide detailed information about the runaway generation process and the confinementof runaway electrons. A vertical soft X-ray array at the top of Joint Texas Experimental Tokamak(J-TEXT) was used to study the runaway beams resulting from major disruptions. Runawayelectron production and confinement of runaway current were observed by using soft X-ray images.
Li, Z.C.,Yang, Y.H.,Dong, Z.F.,Huang, T.,Wu, H. Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.8
This paper aims to evaluate the structural dynamic responses and damage/failure of the nuclear fuel reprocessing plant under the free drop impact of spent fuel cask (SFC) and fuel assembly (FA) during the on-site transportation. At the present Part I of this paper, the large-scale SFC model free drop test and the corresponding numerical simulations are performed. Firstly, a composite target which is composed of the protective structure, i.e., a thin RC plate (representing the inverted U-shaped slab in the loading shaft) and/or an autoclaved aerated concrete (AAC) blocks sacrificial layer, as well as a thick RC plate (representing the bottom slab in the loading shaft) is designed and fabricated. Then, based on the large dropping tower, the free drop test of large-scale SFC model with the mass of 3 t is carried out from the height of 7 m-11 m. It indicates that the bottom slab in the loading shaft could not resist the free drop impact of SFC. The composite protective structure can effectively reduce the damage and vibrations of the bottom slab, and the inverted U-shaped slab could relieve the damage of the AAC blocks layer dramatically. Furthermore, based on the finite element (FE) program LS-DYNA, the corresponding refined numerical simulations are performed. By comparing the experimental and numerical damage and vibration accelerations of the composite structures, the present adopted numerical algorithms, constitutive models and parameters are validated, which will be applied in the further assessment of drop impact effects of full-scale SFC and FA on prototype nuclear fuel reprocessing plant in the next Part II of this paper.
Li, Z.R.,Li, Z.C.,Dong, Z.F.,Huang, T.,Lu, Y.G.,Rong, J.L.,Wu, H. Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.9
Investigations of large commercial aircraft impact effect on nuclear power plant (NPP) buildings have been drawing extensive attentions, particularly after the 9/11 event, and this paper aims to experimentally assess the damage and vibrations of NPP buildings subjected to aircraft crash. In present Part I, two shots of reduce-scaled model test of aircraft impacting on NPP building were carried out. Firstly, the 1:15 aircraft model (weighs 135 kg) and RC NPP model (weighs about 70 t) are designed and prepared. Then, based on the large rocket sled loading test platform, the aircraft models were accelerated to impact perpendicularly on the two sides of NPP model, i.e., containment and auxiliary buildings, with a velocity of about 170 m/s. The strain-time histories of rebars within the impact area and acceleration-time histories of each floor of NPP model are derived from the pre-arranged twenty-one strain gauges and twenty tri-axial accelerometers, and the whole impact processes were recorded by three high-speed cameras. The local penetration and perforation failure modes occurred respectively in the collision scenarios of containment and auxiliary buildings, and some suggestions for the NPP design are given. The maximum acceleration in the 1:15 scaled tests is 1785.73 g, and thus the corresponding maximum resultant acceleration in a prototype impact might be about 119 g, which poses a potential threat to the nuclear equipment. Furthermore, it was found that the nonlinear decrease of vibrations along the height was well reflected by the variations of both the maximum resultant vibrations and Cumulative Absolute Velocity (CAV). The present experimental work on the damage and dynamic responses of NPP structure under aircraft impact is firstly presented, which could provide a benchmark basis for further safety assessments of prototype NPP structure as well as inner systems and components against aircraft crash.
Li, Z.R.,Li, Z.C.,Dong, Z.F.,Huang, T.,Lu, Y.G.,Rong, J.L.,Wu, H. Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.9
Investigations of large commercial aircraft impact effect on nuclear power plant (NPP) buildings have been drawing extensive attentions, particularly after the 9/11 event, and this paper aims to numerically assess the damage and vibrations of NPP buildings subjected to aircrafts crash. In Part I of present paper, two shots of reduce-scaled model test of aircraft impact on NPP were conducted based on the large rocket sled loading test platform. In the present part, the numerical simulations of both scaled and prototype aircraft impact on NPP buildings are further performed by adopting the commercial program LS-DYNA. Firstly, the refined finite element (FE) models of both scaled aircraft and NPP models in Part I are established, and the model impact test is numerically simulated. The validities of the adopted numerical algorithm, constitutive model and the corresponding parameters are verified based on the experimental NPP model damages and accelerations. Then, the refined simulations of prototype A380 aircraft impact on a hypothetical NPP building are further carried out. It indicates that the NPP building can totally withstand the impact of A380 at a velocity of 150 m/s, while the accompanied intensive vibrations may still lead to different levels of damage on the nuclear related equipment. Referring to the guideline NEI07-13, a maximum acceleration contour is plotted and the shock damage propagation distances under aircraft impact are assessed, which indicates that the nuclear equipment located within 11.5 m from the impact point may endure malfunction. Finally, by respectively considering the rigid and deformable impacts mainly induced by aircraft engine and fuselage, an improved Riera function is proposed to predict the impact force of aircraft A380.