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Yuta Yoshino,Takaaki Mori,Taku Yoshida,Yasutaka Toyota,Hideaki Shimizu,Jun-ichi Iga,Shusaku Nishitani,Shu-ichi Ueno 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Objective: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil. Methods: Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil. Results: There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083). Conclusion: Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment
Hiroshi Hayami,Yuta Iga,Syuichi Itahashi,Kazuhiko Miura,Tatsuhiro Mori,Tatsuya Sakurai 한국대기환경학회 2022 Asian Journal of Atmospheric Environment (AJAE) Vol.16 No.3
The global limit on the sulfur content of ship fuel was reduced from 3.50% to 0.50% in January 2020 to reduce ship emissions of SO2 and particulate matter. We conducted observational campaigns before and after the new global limit was introduced to detect changes in coastal air quality. We measured ambient concentrations of SO2 and CO2 ship plumes on shore with the sniffing method under the Kanmon Bridge over the Kanmon Straits between Honshu and Kyusyu Islands, Japan, for several weeks in August to September in 2019 and 2020. The fuel sulfur content (FSC) estimated from our measurements mainly varied from 0.50% to 3.00% in 2019, whereas the range narrowed to 0.10% to 0.40% in 2020, showing that all the ships complied. The mean FSC in 2020 was reduced to 16% of that in 2019, which was consistent with the reduction in the ambient SO2 concentration. Sakurai et al. (2021) estimated that after the 2020 global limit was brought in, SO2 emissions from ships were reduced to 24% of their previous values by assuming that all ships have a FSC of 0.50%. Our results indicate the 2020 global limit led to much greater reductions in SO2 emissions from ships than expected.
Shinichiro Ochi,Saori Inoue,Yuta Yoshino,Hideaki Shimizu,Jun-ichi Iga,Shu-ichi Ueno 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4
Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment- refractory schizophrenic patients.