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      • 정동장애에서의 생물학적 이론에 대한 최근 동향 : 신경화학과 신경내분비 조절 이상 Neurochemical and Neuroendocrine Dysregulation

        연구월,이근후 中央醫學社 1987 中央醫學 Vol.52 No.11

        Neuroendocrine function has been reported by several workers to be abnormal in affec-tive disorder and it has been shown that neurotransmitters are involved in the regulation of neuroendocrine function. Depressed patients demonstrated deregulation in multiple neurochemical and neuro-endocrine systems, many of which are involved stress mediated reactions. Thus it is very intriguing that neuroendocrine & neurochemical abnormalities in depres-sion that we have reviewed involve imbalance of neurotransmitters and deregulation of neuroendocrine that directly or indirectly mediate stress-responsivity in humans. But it is necessary to define how this deregulation becomes translated into the clinical phenomenon of depression as the further research method.

      • 마이크로스트립 지연선 여파기에 관한 연구

        윤준식,박규호,윤철상,박준석,안달 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

        일반적으로 LPA에서는 위상을 조정하기 위해 매우 긴 지연선을 필요로 한다. 지연성능은 고전력이나 저전력 모두에서 임의의 길이의 동축선로를 여러번의 과정을 거쳐 적용해봄으로써 구현된다. 그러나 동축선로형 지연선은 부피나 높은 삽입손실등의 제약이 많이 따른다. 본 논문에서는 마이크로스트립 형태의 지연선 대역통과 여파기를 설계하였고, 실험결과는 지연선여파기가 동축선로를 대신하여 LPA 시스템에 적용이 가능함을 보였다.

      • 간질환자의 항경련제 혈중농도와 정신증상에 관한 연구

        연규월 梨花女子大學校 韓國生活科學硏究院 1991 韓國生活科學硏究院 論叢 Vol.48 No.-

        Recently with increasing recognition of some of the chronic and neuropathological effects of anticonvulsant therapy and the development of technique for measuring serum anticonvulsant levels, more serious attentin is being derected at the possible role of such therapy in the precipitation of mental symptoms. The author studied 61 epileptic patients attending the neuropsychiatric clinic of Ewha Womans University Hospital to confirm the serum anticonvulsant levels in relation to the clinical symptoms of mental state, seizure control and the sign of toxicity from Jan.1, 1990 to May 31, 1991. For each category of mental state(psychomotor slowing, intellectual deterioration, psychiatric illness or personality change), the subjects with evidence of impairment had higher concentration of both DPH and PB, CBZ, VPA than those without such impairment. Those subjects with well controlled seizures had higher concentrations than those with poorly controlled seizures. The sign of toxicity(ataxia and dysarthria) was in the range of therapeutic blood level and 3 of those subject with the sign of toxicity had history of brain damage and abnormal findings of computerized axial tomography of brain. So, the anticonvulsant medication may have an adverse effect on the mental processes of epileptic patients quite apart from an inderectly beneficial effects from controlling seizures in the range of therapeutic blood level.

      • 가족환경이 정신분열증 환자 재발에 미치는 영향

        연규월 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.49 No.-

        Objective : The aim of this work was to study the relationship between intrafamilial expressed emotion(EE) and other prognostic indicators on the schizophrenic relapse. Method : Subjects were 43 schizophrenic patients who were admitted to the department of neuropsychiatry at Ewha Womans university hospital. During hospital admission, their key relatives were interviewed with the Camberwell Family Interview(CFI) and levels of emotional expression were assessed. After discharge from hospital with clinical improvement, all patients were followed-up for a period of nine months and their psychiatric state was assessed to provide information about relapse. Results : The majority of patients were female and unmarried and living with parents. The greater proportion of the key relatives was mother. Remitted patients from high-expressed emotion households relapsed at a significantly higher rate than did those from low expressed emotion households. The best clinical outcome was observed in those patients who redided in low-EE home environments and regularly adhered to antipsychotic medication regimens. Conclusions : There was a significant association between high levels of expressed emotion and relapse for remitted schizophrenic patients and the regular use of medication was a protective factor to the schizophrenic relapse particularly for the patients in high-EE environments.

      • 복합레진중합용 가시광선 조사에 따른 백서 망막의 미세구조학적 변화

        윤필중,양규호 전남대학교 치과대학 1991 전남치대논문집 Vol.3 No.1

        Light-induced retinal damage has been interested in ophthalmic field, and also dental field to deal with resin polymerized by visible light. In this study, ultrastructural observation was performed to reveal morphological change of retina in rat exposed to visible light originated from photo-1curing unit used for polymerization of composite resin. The visible light was exposed variably on eye of rat for 20 to 60 minutes at one time to one group continuously and the other intermittently. There after retinal changes induced by continuous and intermittent light-exposure were compared. The results were as follows ; 1. Photoreceptic myelin membranes were transformed into vesicular structures and outer segment became pearshaped bodies in the periods of 60 minutes and 120 minutes exposures. Inner segment showed swollen mitochondria with vacuoles, and pigment epithelium contained swollen mitochondria and myelin bodies. 2. There were no distinctive differences in the ultrastrucutral changes between single and intermittent exposures in the increased amount of total light exposure. Myelin membranes of intermittent exposure group were also isolated and transformed into vesicular structures, and this fact strongly suggested the cumulative effect of repeated exposures. 3. In the intermittent exposure group, the retina of two minutes exposure was more severely damaged than that of one minute exposure. 4. In the seven days after continuous exposure of 20 minutes, most of disc repaired to normal findings except a few of it disclosed the fingerprint-like arrangement.

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        청소년기 정신과 입원환자의 입원기간에 영향을 미치는 요인

        연규월 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.6

        This study reviewed 145 adolescent consecutive admissions to the psychiatric department at Ewha Womans university Hospital for factors that determine length of hospitalization. Demographic variables and variables describing the socio-economic status, history of suicide attempts, suicide ideation at the time of admission, referral sources, Axis IV score, Axis V score and number of hospitalization were not significantly associated with length of hospitalization. Bur variables describing the discharge diagnosis, history of assault, threat at the time of admission, past history of psychiatric illness, medications received during the index hospitalization, level of functioning(strain ratio=Axis IV/V), and results of follow-up were significantly associated with length of hospitalization. Patients with psychotic/organic disorders had the longest hospitalization and patients with internalizing disorders had the shortest hospitalization. Patients with more prescrived medications had the longest hospitalization and patients who did not receive medications had the shortest hospitalization.

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