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Yun, Sang Pil,Jung, Woo Sang,Park, Sung Uk,Moon, Sang Kwan,Park, Jung Mi,Ko, Chang Nam,Cho, Ki Ho,Kim, Young Suk,Bae, Hyung Sup WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
This study was to test the importance of patterns identification (PI) and the effectiveness of Hwangryunhaedogtang (Huanglianjiedutang) (HT) treatment for patients with post stroke pathological laughter (PL). Fourteen subjects were enrolled. Eight subjects diagnosed with Yang Excess patterns (YEP) were assigned into group A and 6 subjects who had no YEP to group B. HT was administrated 3 times a day for 14 days to both groups. The duration of PL at one time. the frequency of PL in a day, and pathological laughter scale (PLS) were the primary outcome measures. Barthel index (BI) was the secondary outcome measure. The duration and the frequency of PL in group A were significantly decreased from 10.88 ± 4.67 to 6.63 ± 4.07 sec and from 6.38 ± 2.72 to 3.00 ± 1.77 times. respectively (p = 0.01) after 14 days administration of HI. PLS in group A was also significantly lowered from 9.13 ± 1.73 to 4.75 ± 0.71 points (p = 0.01). However, significant differences were not observed in BI in group A and in the primary and secondary outcome measures in group H. The duration and the frequency ofPL and PLS were more markedly reduced in group A than in group B(p = 0.01. 0.02, and < O.O1, respectively), These results suggested that HT could be effective on subjects with post stroke PL diagnosed as YEP and PI, that prescription of herbal medications to such patients should be considered.
Complication analysis of distal pancreatectomy based on early personal experience
Sung-Jin Park,Hyung-Il Seo,Soo-Hee Go,Sung-Pil Yun,Ji-Yeon Lee 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.4
Backgrounds/Aims: The objective of this study was to evaluate the relationship between initial personal experiences with distal pancreatectomy and perioperative risk factors, outcomes, and management of pancreatic fistulas. Methods: Between May, 2007 and May, 2010, a total of 28 patients who had undergone elective distal pancreatectomy were evaluated for this study. Perioperative factors and the occurrence of pancreatic fistula were analyzed on the basis of International Study Group of Pancreatic Fistula (ISGPF) criteria. Results: There were sixteen cases of benign neoplasms and twelve cases of malignant tumors. The remnant pancreas was manually sutured with ligation of the pancreatic duct (n=14), auto-suture stapling along with manual sutures (n=12), or stapling alone (n=2). According to the ISGPF classification, morbidity and mortality associated with pancreatic fistulas was 42.9% (n=12) and 0%, respectively. These pancreatic fistulae were classified as grade A in 8 cases (28.6%), grade B in 3 cases (10.7%), and grade C in one case (3.6%). All patients with pancreatic fistula were treated conservatively. Conclusions: Perioperative factors do not affect the risk of pancreatic fistula. Adequate drainage is the most effective method for management of a pancreatic fistula after distal pancreatectomy. (Korean J Hepatobiliary Pancreat Surg 2011;15:243-247)
( Sung Eun Kim ),( Young Pil Yun ),( Dong Hun Suh ),( Young Ran Kim ),( Kyeong Soon Park ),( Yong Dae Kwon ),( Joon Ho Suh ),( Jun Young Chung ),( Deok Won Lee ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.4
Titanium (Ti) has been widely used in the dental field owing to its good biocompatibility, superior mechanical properties, and excellent corrosion resistance. However, Ti lacks the osteoconductivity and osteoinductivity required to promote mineralization. In the present study, the authors investigated whether apatite-coated Ti and rhBMP-2 treated apatite-coated Ti promote more mineralization than pristine Ti. Characterizations of pristine Ti, apatite-coated Ti, or rhBMP-2/apatite-coated Ti were analyzed using scanning electron microscopy (SEM), energydispersive spectroscopy (EDS), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). In addition, the release profile of rhBMP-2 from rhBMP-2/apatite-coated Ti was monitored for 28 days, and the biocompatibility of pristine Ti, apatite-coated Ti, and rhBMP-2/apatite-coated Ti was evaluated by measuring cell proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and real-time PCR using MG-63 cells. SEM, EDS, and ATR-FTIR showed that the apatite on apatite-coated Ti surfaces was similar to that of natural bone. Furthermore, rhBMP-2 appeared to be released steadily over 28 days from rhBMP-2/apatite-coated Ti, and MG-63 cells grown on rhBMP-2/apatite-coated Ti showed significantly higher proliferation activity, ALP activity, and calcium deposition compared to MG-63 cells grown on pristine Ti or apatite-coated Ti. Furthermore, osteocalcin and osteopontin gene expression in MG-63 cells grown on rhBMP-2/apatite-coated Ti was significantly greater than that in MG-63 cells grown on pristine Ti or apatite-coated Ti by real-time PCR. Taken together, rhBMP-2/apatite-coated Ti substrate has enhanced osteoblast function and mineralization. Thus, rhBMP-2/apatite-coated Ti may be a more effective substrate than pristine Ti used in the dental field.
WETTABILITY AND DRUG DELIVERY OF FUNCTIONALLY GRADED NANO-MICRO POROUS TITANIUM SURFACE
Yun, Kwi-Dug,Vang, Mong-Sook,Yang, Hong-So,Park, Sang-Won,Park, Ha-Ok,Lim, Hyun-Pil The Korean Academy of Prosthodonitics 2008 대한치과보철학회지 Vol.46 No.3
STATEMENT OF PROBLEM: It is known that an anodic oxidation technique, one of the methods for the implant surface treatment, remarkably increased surface area, enhanced wettability and accelerated the initial bone healing. Purpose: This study was performed to evaluate the wettability of anodized titanium surface which has a nanotubular structure, to assess osseointegration after the placement of implant with nano-size tubes on tibia of rats and to analyze quantitatively transferable rhBMP-2 on each surface. MATERIAL AND METHOD: Four different kinds of surface-treated titanium discs (polished (machined surface) group, micro (blasting surface) group, nano (anodizedmachined surface) group, and nano-micro (anodized-blasting surface) group) were fabricated (n=10). Three different media were chosen to measure the surface contact angles; distilled water, plasma and rhBMP-2 solution. After a single drop (0.025 $m{\ell}$) of solution, the picture was taken with the image camera, and contact angle was measured by using image analysis system. For the test of osseointegration, 2 kinds of anodized surface (anodized-machined surface, anodized-blasting surface) implants having 2.0 mm in diameter and 5.0 mm in length inserted into the tibia of Wistar rats. After 3 weeks, tibia were harvested and the specimens were stained with hematoxylin and eosin for histological analysis. To test the possibility of drug delivery, after soaking sample groups in the concentration of 250 ng/$m{\ell}$l of rhBMP-2 for 48 hours, the excess solution of rhBMP-2 were removed. After that, they were lyophilized for 24 hours, and then the rhBMP-2 on the surface of titanium was resolved for 72 hours in PBS. All the extracted solution was analyzed by ELISA. One-way analysis of variance (ANOVA) was performed on the data. RESULTS: The wettability is improved by anodic oxidation. The best wettability was shown on the nano-micro group, and it was followed by nano group, micro group, and polished group. In the histological findings, all implants showed good healing and the new bone formation were observed along the implant surface. After 3 days, nano-micro group delivered the most amount of rhBMP-2, followed by nano group, micro group, and polished group. CONCLUSION: It indicated that anodic oxidation on blasting surface produce functionally graded nano-micro porous structure and enhance hydrophilicity of the surface and osseointegration. The findings suggest that the nano-micro porous structure could be a useful carrier of osteogenic molecules like rhBMP-2.
Yun, Kwi-Dug,Yang, Yunzhi,Lim, Hyun-Pil,Oh, Gye-Jeong,Koh, Jeong-Tae,Bae, In-Ho,Kim, Jaehyung,Lee, Kwang-Min,Park, Sang-Won Elsevier 2010 Materials science & engineering. C, Materials for Vol.30 No.1
<P><B>Abstract</B></P><P>This study was to evaluate wettability, cell response, and osseointegration of nanotubular titanium (Ti) surface by anodic oxidation. Commercially pure Ti discs were treated by polishing, sandblasting, and anodizing. These surfaces were characterized by scanning electron microscopy and contact angle measurement. MC3T3-E1 osteoblast cell was used to evaluate cell response <I>in vitro</I>. The cell morphology, cell viability, and alkaline phosphatase (ALP) specific activity were assessed. The Ti implants of 2.0mm diameter and 5.0mm long treated by anodizing and sandblasting/anodizing were inserted into the tibia of rats. After 3weeks, the histology of the Ti–bone interface was examined. SEM observations showed that the anodizing and sandblasting/anodizing created the nanotubular surface and graded nanotubular-micro-roughened surfaces, respectively. The anodizing and sandblasting/anodizing significantly improved the hydrophilicity of Ti. The significant greatest cell spreading and ALP specific activity were observed on the graded nanotubular-micro-roughened surfaces treated by sandblasting/anodizing. The <I>in vivo</I> study shows that newly formed bone was intimately in contact with the nanotubular surfaces without adverse immune response. This study has suggested that the graded nanotubular-micro-roughened surface of Ti treated with sandblasting/anodizing is very promising in implantology due to improved hydrophilicity, favorable cell response, and excellent osseointegration.</P>
Yun, Jeong Woo,Yoon, Sung Pil,Park, Sanggyun,Han, Jonghee,Nam, Suk Woo,Lim, Tae-Hoon,Kim, Jin-Soo Elsevier 2009 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.34 No.22
<P><B>Abstract</B></P><P>To increase the performance of solid oxide fuel cells operated at intermediate temperatures (<700°C), we used the electronic conductor La<SUB>0.8</SUB>Sr<SUB>0.2</SUB>MnO<SUB>3</SUB> (LSM) and the mixed conductor La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>Co<SUB>0.2</SUB>Fe<SUB>0.8</SUB>O<SUB>3</SUB> (LSCF) to modify the cathode in the electrode microstructure. For both cathode materials, we employed a Sm<SUB>0.2</SUB>Ce<SUB>0.8</SUB>O<SUB>2</SUB> (SDC) buffer layer as a diffusion barrier on the yttria-stabilized zirconia (YSZ) electrolyte to prevent the interlayer formation of SrZrO<SUB>3</SUB> and La<SUB>2</SUB>Zr<SUB>2</SUB>O<SUB>7</SUB>, which have a poor ionic conductivity. These interfacial reaction products were formed only minimally at the electrolyte–cathode interlayer after sintering the SDC layer at high temperature; in addition, the degree of cathode polarization also decreased. Moreover to extend the triple phase boundary and improve cell performance at intermediate temperatures, we used sol–gel methods to coat an SDC layer on the cathode pore walls. The cathode resistance of the LSCF cathode cell featuring SDC modification reached as low as 0.11Ωcm<SUP>2</SUP> in air when measured at 700°C. The maximum power densities of the cells featuring the modified LSCF and LSM cathodes were 369 and 271mW/cm<SUP>2</SUP>, respectively, when using O<SUB>2</SUB> as the oxidant and H<SUB>2</SUB> as the fuel.</P>
Comparison of Outcomes between STEMI and NSTEMI patients with Totally Occluded IRA (초)
( Sang Woong Choi ),( Yun Kyeong Cho ),( Jae Pil Lee ),( Ji Hyun Sohn ),( Hyun Ok Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yoon Nyun Kim ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
New organic 4‐(4‐methoxystyryl)‐1‐methylpyridinium crystals for nonlinear optical applications
Yun-Sang Lee,O-Pil Kwon,Woojin Yoon,Hoseop Yun,Mojca Jazbinsek4,In Cheol Yu,Fabian Rotermund,Dongwook Kim 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.11
In this study, an organic nonlinear optical salt crystal, 4-(4-methoxystyryl)-1-methylpyridinium 4-bromobenzenesulfonate (MOS-BBS), is newly reported. MOS-BBS crystals exhibit perfectly parallel molecular ordering of 4-(4-methoxystyryl)-1-methylpyridinium (MOS) cationic chromophores with noncentrosymmetric P1space group symmetry, which provides an optimal configuration for maximizing themacroscopic second-order optical nonlinearity. The macroscopic optical nonlinearityof the MOS-BBS crystals is very large, with the diagonal effective first hyperpolarizabilityof 160 1030 esu. Furthermore, the MOS-BBS crystals exhibit a high thermalcrystal-phase stability. The lowest phase transition temperature of the MOS-BBS crystalsis 265C, which is ~90C higher than that of previously reported MOS-basedcrystals.