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- 저자 : Yuce Li (검색결과 2 건)
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아누 프,Yuce Li,박재형 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Targeted drug delivery and controlled drug release remain challenging. To address this challenge, we synthesized intracellular nitric oxide-generating nanoparticles (NO-NPs) for tumor site-specific generation of vasodilator NO to enhance NP accumulation in tumor tissue, i.e., improve their enhanced permeability and retention (EPR) effect. These NPs are self-assembled from amphiphilic copolymers of poly(ethylene glycol) and nitrated dextran, which possesses inherent NO-releasing properties in the reductive intracellular microenvironment. After systemic administration of NO-NPs, we quantitatively appraised the increased tumor blood flow and enhanced vascular permeability than that achieved without NO. Additionally, we prepared doxorubicin (DOX)-encapsulated NO-NPs and demonstrated substantial therapeutic efficacy over the control groups with improved intratumoral DOX accumulation. Overall, we anticipate NO-NPs being an EPR enhancer to achieve a better anticancer therapeutic efficiency.
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Treatment of Hepatic Fibrosis by Using Human Mesenchymal Stem Cell-derived Exosomes
Dat Bui Van,Yuce Li,박재형 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Mesenchymal stem cell (MSC) therapy has emerged as a potential treatment for chronic diseases due to its regenerative ability. However, it has significant limitations such as cell’s movement, changing into inappropriate cell types, or growth of tumors. In order to overcome these risks, a revolutionary cell-free therapy was developed to treat the chronic disease, particularly hepatic fibrosis, by using human adipose stem cell-derived exosomes (hADSC-exos). The hADSC-exos were isolated from conditioned media of ADSCs using tangential flow filtration (TFF) method, then were suspended in PBS and stored at –80 °C. After intravenous injected into the liver-fibrotic mice, hADSC-exos preferred to maintain inside the livers, especially in damaged liver tissue, notably suppressed fibro genic markers and finally restored hepatic functions. In conclusion, exosomes derived from hADSC have a dramatic potential to treat chronic hepatic fibrosis.
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