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Yu, Jinho The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.12
Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood. Further studies focused on obtaining serial measurements of lung function in infants and toddlers with a risk of bronchiolitis obliterans (BO) after lower respiratory tract infection are therefore needed. Although an optimal treatment for PIBO has not been established, corticosteroids have been used to target the inflammatory component. Other treatment modalities for BO after lung transplantation or hematopoietic stem cell transplantation have been studied in clinical trials, and the results can be extrapolated for the treatment of PIBO. Lung transplantation remains the final option for children with PIBO who have progressed to end-stage lung disease.
Comparison of Bag Weight and Applied Location on Plantar Pressure and Gait in the Twenties Student
Jinho Yu,Jaecheol Park,Min Gyun Ko 물리치료재활과학회 2023 Physical therapy rehabilitation science Vol.12 No.2
Objective: The purpose of this study is to confirm a comparison of bag weight and applied location change on plantar pressure and gait parameters (stride time, stride length, cadence) of the 20s students. Design: One group cross-sectional designMethods: The subjects were measured in each condition. Each condition was no carrying a bag, carrying a 3kg bag, and a 6kg bag on the right shoulder, and walked on the gait analyzer. After the location of the bag was changed, measured when a 3kg backpack and a 6kg backpack was each carried on the back while walking. Results: There was a statistically significant difference in plantar pressure according to bag weight when carried on the right shoulder (p<0.05). As a result of the post-hoc analysis, carrying a 6kg bag was a significant difference between no carrying a bag and carrying a 3kg bag (p<0.05). There was no statistically significant difference in changes in stride time, stride length, and cadence. There was no statistically significant difference in plantar pressure and gait parameters according to backpack weight. Conclusions: As a result of this study, it is thought that it will be possible to present a method for the application of the correct bag on location and weight in 20s students, and to prevent and reduce muscle musculoskeletal system diseases caused by incorrect bag wearing.
Yu, Mi Kyung,Jeong, Yong Yeon,Park, Jinho,Park, Sangjin,Kim, Jin Woong,Min, Jung Jun,Kim, Kyuwon,Jon, Sangyong WILEY-VCH Verlag 2008 Angewandte Chemie. international edition Vol.47 No.29
<B>Graphic Abstract</B> <P>Multitasking rust ball: The questions of where a tumor is located, whether drugs are properly delivered to the tumor, and what the therapeutic response of the tumor is, could be answered by using simple but smart, drug-loaded superparamagnetic iron oxide nanoparticles that can accumulate in tumor with high efficiency thanks to the presence of rationally engineered polymer coating layers. <img src='wiley_img/14337851-2008-47-29-ANIE200800857-content.gif' alt='wiley_img/14337851-2008-47-29-ANIE200800857-content'> </P>
YU, Do-Hyeon,NOH, Dong-Ho,SONG, Ru-Hui,PARK, Jinho Japanese Society of Veterinary Science 2010 The Journal of veterinary medical science Vol.72 No.10
<P>We investigated the anti-inflammatory effects of ethyl pyruvate (EP) on LPS-stimulated canine PBMCs <I>in vitro</I>. We found that EP treatment inhibited the mRNA expressions of proinflammatory cytokines (TNF-α and IL-6), but induced mRNA expression of anti-inflammatory cytokines (IL-10). ELISA measurements revealed that EP also effectively downregulates the LPS-induced increase in proinflammatory cytokine release, while upregulating anti-inflammatory cytokine release. These data indicate that EP could be an effective anti-inflammatory agent in dogs.</P>
Serial Changes of CD4+CD25+FoxP3+ Regulatory T Cell in Canine Model of Sepsis Induced by Endotoxin
YU, Dohyeon,KIM, Junhwan,PARK, Chul,PARK, Jinho The Japanese Society of Veterinary Science 2014 The Journal of veterinary medical science Vol.76 No.5
<P><B>ABSTRACT</B></P><P>Regulatory T cells (Tregs) suppress the immune system and maintain the homeostasis of the immune system in healthy dogs. In septic patients, the percentage of circulating Tregs is increasing, which may cause the sepsis-induced immunosuppression. This study was performed to investigate the changes of the percentage of Tregs in total lymphocytes of the peripheral blood in the experimental canine endotoxemia model. The animals injected with a high dose lipopolysaccharide (LPS) induced severe leukopenia followed by leukocytosis, but the total lymphocytes number was relatively consistent. As a result of flow cytometric analysis, the percentage of Tregs in total lymphocytes of the peripheral blood was 8.45 ± 1.30% (day 0), and it temporarily decreased 2.54 ± 1.16% (day 1) and increased continuously until the end of the experiment (14.34 ± 4.10% on day 3 and 25.70 ± 7.39% on day 7), respectively. This study provides basic information in physiologic and immunologic changes in Tregs in dogs with sepsis model.</P>
Yu, Do-Hyeon,Nho, Dong-Ho,Song, Ru-Hui,Kim, Sue-Hee,Lee, Mi-Jin,Nemzek, Jean A.,Park, Jinho Wiley (Blackwell Publishing) 2010 Journal of veterinary emergency and critical care Vol.20 No.3
<P>OBJECTIVE: To evaluate various surrogate markers associated with the inflammatory and counter-inflammatory responses with respect to mortality in dogs with systemic inflammatory response syndrome (SIRS). DESIGN: Prospective observational study. SETTING: Veterinary Teaching Hospital. ANIMALS: Twenty-eight dogs with naturally occurring diseases and SIRS from January 2007 to May 2009. INTERVENTIONS: Upon admission to the veterinary hospital, history and baseline data from the physical examination, including parameters previously defined for meeting SIRS criteria, were documented. Heparinized blood samples were collected and plasma cytokines interleukin-6 (IL-6), IL-10, and high-mobility group box 1 (HMGB1) were measured by sandwich ELISA. MEASUREMENTS AND MAIN RESULTS: In nonsurvivors, median plasma HMGB1 concentrations (0.718 microg/L, interquartile range [IQR]; 0.300-1.626 microg/L) and the ratio of HMGB1 to IL-10 (2.236, IQR; 0.972-5.367) were significantly increased as compared with those found in survivors (0.300 microg/L, IQR; 0.300-0.312 microg/L for HMGB1; 1.017, IQR; 0.862-1.126 for the ratio of HMGB1 to IL-10, P=0.007 and 0.024, respectively). Plasma IL-6, IL-10, and the ratio of IL-6 to IL-10 were not significantly different between groups. Among the parameters studied, HMGB1 and the ratio of HMGB1 to IL-10 performed the best in discriminating outcome in dogs with SIRS according to receiver operator characteristic curve analysis. CONCLUSIONS: Increases in plasma HMGB1 concentration and the ratio of HMGB1 to IL-10 may predict poorer outcomes in dogs with SIRS. The approach described may lead to reliable prognostic biomarkers and new therapeutic concepts in the study of SIRS in dogs.</P>
Compressive Channel Division Multiple Access for MTC Under Frequency-Selective Fading
Jinho Choi,Nam Yul Yu Institute of Electrical and Electronics Engineers 2017 IEEE Transactions on Communications Vol. No.
<P>In this paper, we study random access for machine-type communications based on a multiple access scheme that exploits different channel state information (CSI) from active devices under frequency-selective fading, which is called channel division multiple access (ChDMA). In ChDMA, in order to use a low-complexity compressive sensing (CS) algorithm for multiuser detection (MUD) with a high transmission rate, we propose to use index modulation. Since the CSI is used as a signature for MUD, the CSI estimation becomes crucial. For the CSI estimation, pilot transmission can be considered where each active device randomly chooses a pilot from a set of pre-determined pilots. Since the CSI estimation suffers from pilot collision in this case, we propose multiple pilot transmissions and show that a low probability of collision can be achieved. A CS-based approach is derived not only to estimate the CSI, but also to detect randomly selected multiple pilot signals by exploiting the sparsity of active devices over frequency-selective fading channels.</P>