http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Clinical Outcome of Patients that Underwent Tracheostomy in Medical Intensive Care Unit
( Se Hyun Kwak ),( Nam Eun Kim ),( Youngmok Park ),( Seung Hyun Yong ),( Ah Young Leem ),( Sang Hoon Lee ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Moo 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background We evaluated survival after tracheostomy and identified potential variables predicting weaning outcome in patients who underwent tracheostomy. Methods We retrospectively reviewed the medical records of patients that underwent tracheostomy in medical intensive care unit (ICU) of a tertiary referral hospital in South Korea between July 11, 2016 and April 10, 2019. We excluded patients who underwent tracheostomy before ICU admission and those who failed discontinuation of mechanical ventilation. The primary outcome was weaning failure, defined as prolonged home ventilator support. Tracheostomy tube de-cannulation or sealing off were considered a successful weaning, Results 271 patients received tracheostomy, and a total of 182 patients were included with a median age of 68.2 (IQR 57.5-77.0) years and median APACHE II score of 26.0 (IQR 20.5-31.0). The most common indication for tracheostomy was pulmonary problems (74.7%), followed by neurologic (8.8%), cardiac (3.3%), and neuromuscular (1.1%) problems. The median ICU length of stay was 89.5 (IQR 56.5-150.3) days and overall in-hospital mortality was 19.2%. Of the 182 patients, 113 (62.1%) experienced successful weaning, otherwise 69 (37.9%) patients failed to wean. There was statistically significant longer survival in weaning success group to weaning failure group (p<0.001). Multivariated analysis showed that potential factors associated with weaning failure were past history of coronary artery occlusive disease (CAOD, odds ratio [OR], 3.045; 95% confidence interval [CI], 1.237 to 7.494; p=0.015) and congestive heart failure (CHF, OR, 3.464; 95% CI, 1.171 to 10.246; p=0.025). Conclusions In our ICU, 62.1% of patients who received tracheostomy were successfully weaned. The most common reason of tracheostomy was pulmonary problems. In addition, CAOD and CHF could be predictive of weaning failure in ICU patients who underwent tracheostomy.
Physiologic and Radiologic Changes After Coronavirus Disease (COVID-19) in Lung Transplantation
( Hye Young Hong ),( Seung Hyun Yong ),( Youngmok Park ),( Ah Young Leem ),( Su Hwan Lee ),( Kyung Soo Chung ),( Sang Hoon Lee ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( M 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
Hong Hye Young,Park Youngmok,Yong Seung Hyun,Woo Ala,Leem Ah Young,Lee Su Hwan,Chung Kyung Soo,Lee Sang Hoon,Kim Song Yee,Kim Eun Young,Jung Ji Ye,Park Moo Suk,Kim Young Sam,Shin Sung Jae,Kang Young A 대한의학회 2024 Journal of Korean medical science Vol.39 No.2
Background: The treatment success rate for tuberculosis (TB) has stagnated at 80–81% in South Korea, indicating unsatisfactory outcomes. Enhancing treatment success rate necessitates the development of individualized treatment approaches for each patient. This study aimed to identify the risk factors associated with unfavorable treatment outcomes to facilitate tailored TB care. Methods: We retrospectively analyzed the data of patients with active TB between January 2019 and December 2020 at a single tertiary referral center. We classified unfavorable treatment outcomes according to the 2021 World Health Organization guidelines as follows: “lost to follow-up” (LTFU), “not evaluated” (NE), “death,” and “treatment failure” (TF). Moreover, we analyzed risk factors for each unfavorable outcome using Cox proportional hazard regression analysis. Results: A total of 659 patients (median age 62 years; male 54.3%) were included in the study. The total unfavorable outcomes were 28.1%: 4.6% LTFU, 9.6% NE, 9.1% deaths, and 4.9% TF. Multivariate analysis showed that a culture-confirmed diagnosis of TB was associated with a lower risk of LTFU (adjusted hazard ratio [aHR], 0.25; 95% confidence interval [CI], 0.10–0.63), whereas the occurrence of adverse drug reactions (ADRs) significantly increased the risk of LTFU (aHR, 6.63; 95% CI, 2.63–16.69). Patients living far from the hospital (aHR, 4.47; 95% CI, 2.50–7.97) and those with chronic kidney disease (aHR, 3.21; 95% CI, 1.33–7.75) were at higher risk of being transferred out to other health institutions (NE). Higher mortality was associated with older age (aHR, 1.06; 95% CI, 1.04–1.09) and comorbidities. The ADRs that occurred during TB treatment were a risk factor for TF (aHR, 6.88; 95% CI, 2.24–21.13). Conclusion: Unfavorable outcomes of patients with TB were substantial at a tertiary referral center, and the risk factors for each unfavorable outcome varied. To improve treatment outcomes, close monitoring and the provision of tailored care for patients with TB are necessary.
Incidence and Risk Factors for Brain Metastasis in Patients with Presumed Early-stage Lung Cancer
( Kangjoon Kim ),( Ala Woo ),( Youngmok Park ),( Seung Hyun Yong ),( Su Hwan Lee ),( Ah Young Leem ),( Song Yee Kim ),( Kyungsoo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Regarding whether brain magnetic resonance imaging (MRI) should be routine in patients with presumed early-stage lung cancer, guideline recommendations are inconsistent. In this regard, we performed the study to evaluate the incidence and risk factors for brain metastasis (BM) in patients with presumed early-stage non-small cell lung cancer (NSCLC). Method A review of the medical charts of consecutive NSCLC patients diagnosed between January 2006 and May 2020 was performed. We identified 1,382 patients who were diagnosed with NSCLC with clinical stage of T1/2aN0M0 apart from brain MRI result (Figure 1). Firth’s bias-reduced logistic regression were used to assess predictors of BM. Fisher’s exact test with the minimum p-value approach was used to determine the optimal cut-off value in tumor size predicting BM. Result Six hundred fifty-one patients (47.1%) were female; mean ± SD age was 64.3 ± 10.4 years. Nine hundred forty-nine patients (68.7%) underwent brain MRI during staging, and 34 patients (3.6%) were shown to have BM. Firth’s bias-reduced logistic regression model showed that tumor size in millimeters (OR 1.056; 95% CI 1.009-1.106) was a single predictor for presence of BM. A cut-off value of 3.5 cm in tumor size was predictive for BM in our cohort (OR 4.538; CI 95% 1.977-9.650). The median overall survival of the participants with BM was 5.5 year and 5-year survival rate was 59.8%. Conclusions Given the incidence and favorable outcome of BM in patients with presumed early-stage NSCLC, routine screening of brain MRI might be considered, especially in patients with tumor size of ≥3.5 cm.
( Kangjoon Kim ),( Ala Woo ),( Youngmok Park ),( Seung Hyun Yong ),( Su Hwan Lee ),( Sang Hoon Lee ),( Ah Young Leem ),( Song Yee Kim ),( Kyungsoo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae K 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Studies on risk and protective factors for lung function decline and mortality in rheumatoid arthritis-related interstitial lung disease (RA-ILD) are limited. Therefore, we aimed to investigate clinical factors and medication uses associated with lung function decline and mortality in patients with RA-ILD. Methods This retrospective cohort study examined patients with RA-ILD who visited Severance Hospital, a university-affiliated tertiary referral hospital in South Korea, between January 2006 and December 2019. From 3,946 consecutive RA patients, we selected 170 participants with RA-ILD with at least one spirometry (Figure 1). Absolute FVC decline ≥10% was defined as significant decline of pulmonary function. Valid medical treatment was defined as continuation of medication for at least 12 weeks in the period between diagnosis date of RA and the last follow-up. Data were retrieved from electronic medical records. Results Ninety patients (52.9%) were female; mean ± SD age was 64.0 ± 10.2 years. Multivariate logistic regression showed that high ESR at RA diagnosis (≥81.5 mm/hr) (OR 3.056; 95% CI 1.183-7.890) and history of methotrexate (MTX) use (OR 0.269; 95% CI 0.094-0.769) were identified as risk and protective factors for lung function decline, respectively. Multivariate cox regression analysis showed that age 65 years or older (OR 2.723; 95% CI 1.142-6.491), radiologic pattern of usual interstitial pneumonia (UIP) or probable UIP (OR 3.948; 95% CI 1.522-10.242, p=0.005), baseline FVC % predicted (OR 0.971; 95% CI 0.948-0.994), and history of MTX use (OR 0.284; 95% CI 0.091-0.880) predicted mortality in the cohort. Conclusions MTX use was associated with favorable outcome in terms of lung function and mortality in our cohort. A largersized, prospective study may be warranted to investigate beneficial effect of MTX on RA-ILD.
Hee-Young Jang,Soo Jong Kwon,Ki-Hyun Kim,Keun-Yook Chung,Yong-Gu Cho,Jong-Soon Choi,YoungMok Park,Setsuko Komatsu,Sun-Hee Woo 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Recently, proteome analysis is becoming a powerful tool for the functional characterization of plants. Due to the availability of vast nucleotide sequence information and based on the progress achieved in sensitive and rapid protein identification by mass spectrometry, proteome approaches open up now perspectives to analyze the complex functions of model crop species at different level. In this study, we have N-terminal sequencing data for the 100 embryo and 53 seed proteins of rice separated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) were collected and systematically organized for a protein sequence data-file. An attempt was made to link the embryo proteins of rice to DNA sequences for understanding their functions. One hundred proteins of the 700 spots were detected in the embryo using 2-DE gels whereas we used micro sequenced. Of these, 28% of the embryo proteins were matched to DNA sequences with known functions, but 72% of the proteins were identified to be unknown functions as previously reported by Woo et al.,. In addition, twenty-four spots of protein with 100% of homology and nine with over 80% were matched to ESTs (expressed sequence tags) after expanding the amino acid sequences of the protein spots by Database searches using the available EST databases of rice at the NCBI (http://www/ncbi.nlm.nih.gov/) and DDBJ (http://www.ddbj.nig.ac.jp/). Also, a total of 53 proteins out of 700 protein spots separated on the 2-DE gels were analyzed by the peptide mass fingerprinting method (MALDI-TOF/MS). High-quality mass spectra suitable for peptide mass fingerprinting were obtained from 41 spots. Using the ESI-Q-TOF/MS, however, we were able to identify 53 seed proteins of rice, including 12 proteins not registered in database. The rapid expansion of DNA sequence databases to the utilization of EST now provides the whole or partial gene sequences of model organisms, and the recent advances in protein micro-characterization by mass spectrometry allow the possibility of linking these DNA sequences to the proteins in functional complexes. Proteome Database of rice is updated, and is available on the World Wide Web at http://gene64.rda.affrc.go. This work shows that the proteome analysis could be a useful strategy to link the sequence information to the functional genomics.