An exact algorithm for robust flying-sidekick Traveling Salesman Problem

Youngjoo Roh(노영주),Jaegwan Joo(주재관),Chungmok Lee(이충목) 대한산업공학회 2021 대한산업공학회 춘계학술대회논문집 Vol.2021 No.6

An exact algorithm for robust flying-sidekick Traveling Salesman Problem

Youngjoo Roh(노영주),Jaegwan Joo(주재관),Chungmok Lee(이충목) 한국경영과학회 2021 한국경영과학회 학술대회논문집 Vol.2021 No.6

Lifting Heuristic for Robust Cover Inequalities for Robust Knapsack Problem

Youngjoo Roh,Junyoung Kim,Kyungsik Lee 대한산업공학회 2023 대한산업공학회 추계학술대회논문집 Vol.2023 No.11

Molecular networks underlying ovarian aging for clinical applications

YoungHo Roh,SookRyung Kim,EunJung Choi,YoungJoo Kim,HyangGi Park,PureunNarae Kang,DaJung Chung,NaYoung Kim,MinJae Kim,AeRa Han,KwangRae Kim,Chan Park,YongPil Cheon,YoungJin Lee 한국발생생물학회 2017 한국발생생물학회 학술발표대회 Vol.2017 No.8

Due to modern trends with postponing child-bearing and getting worse living environment in women, an ovarian aging increased pregnancy failure and other complications with menopause or premature ovarian failure. Although several theories have been suggested such as mitochondrial malfunction, DNA damage/repair/methylation, caloric restriction, studies regarding ovarian aging-related molecular mechanisms for development of therapeutic methods are insufficient so far. Our objective is to determine molecular pathways of ovarian aging that result in pregnancy failure and other complications in women health to develop treatment strategies. This study is consisted of two parts: in Phase I stage, we analyzed distinct gene expression profile between young and aged mouse ovaries, and in Phase II stage several preferentially expressed genes in both ovaries were selected and analyzed their physiological functions and involved molecular networks related to ovarian aging for development of diagnostic markers and therapeutic methods. Ovaries from 10 week and 11 month-old FVB/NJ female mice with synchronized estrus cycle were collected for this study. A half of each ovary was used for RNA preparation and the other half for histological analysis. Using the Illumina HiSeq 2000 System, preferentially expressed genes were identified. Functional annotation database-based gene-set enrichment analyses and Pathway Studio® were employed to evaluate aging-related molecular networks. These findings were confirmed through qRT-PCR and immunohistochemistry. To validate RNA-Seq data, we examined expression patterns of marker genes (Amh, Bmp15 and Nobox) that were wellknown to be decreased in ovarian aging process. In young or aged ovary, preferentially expressed 876 genes were identified and extracellular matrix (ECM; p<0.001) and chromatin/nucleosome-related (p<0.001) protein-coded genes have the majority in these genes by GOTERM analysis. Amongthem, we selected several candidate genes and confirmed their expression profiles by qRT-PCR and immunohistochemistry followed by molecular network analysis. Regarding molecular interactions in these genes, PathwayStudio® was employed to predict aging-involved molecular networks in mouse ovary. Here we report a couple of candidate molecular networks and medicines (chemicals) for targeting these preferentially expressed genes/proteins. Further analyses are scheduled to produce transgenic animal models and with human ovarian tissues/cell lines.

The clinical impact of family history of cancer in female never-smoker lung adenocarcinoma

Lee, Youngjoo,Jeon, Jae Hyun,Goh, Sung-Ho,Roh, Hanseong,Yun, Ji-Young,Kwon, Nak-Jung,Choi, Jin Ho,Yang, Hee Chul,Kim, Moon Soo,Lee, Jong Mog,Lee, Geon Kook,Han, Ji-Youn Elsevier 2019 Lung cancer Vol.136 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Accumulating evidence reveals the association between the risk of never-smoker lung cancer and family history of cancer. However, the clinicogenomic effect of family history of cancer in never-smoker lung cancer remains unknown.</P> <P><B>Material and methods</B></P> <P>We screened 3,241 lung cancer patients who (a) underwent curative resection at National Cancer Center (Goyang, Korea) between 2001–2014, and (b) completed a pre-designed interview about family/smoking history at the time of diagnosis and identified 604 female never smoker lung adenocarcinoma. A positive family history of cancer [categorized as pulmonary cancer (FH-PC) or non-pulmonary cancer (FH-NPC)] was defined as a self-reported history of cancer in first-degree relatives. Survival data were followed up until January 2017. Multiplexed targeted next-generation sequencing was performed for genetic profiling.</P> <P><B>Results</B></P> <P>Of 604 patients, 29.1% (n = 176) had a FH, including 132 (21.9%) with FH-NPC and 44 (7.3%) with FH-PC. Patients with the FH-NPC had a higher proportion of young patients (≤45 years) than those without the FH-NPC (FH-NPC, FH-PC, and no FH; 13.6%, 2.3%, and 8.2%, respectively; <I>P</I> = 0.032). Patients with the FH-NPC had an increased risk of recurrence (hazard ratio [HR]: 1.90; 95% confidence interval [CI]: 1.40–2.56; <I>P<</I>0.001) and death (HR: 1.67; 95% CI: 1.18–2.37; <I>P=</I>0.004). In contrast, the FH-PC had no prognostic effect on recurrence (HR: 1.23; 95% CI: 0.71–2.15; <I>P = 0.456</I>) and death (HR: 0.93; 95% CI: 0.45–1.91; <I>P=</I>0.838). Among three driver oncogene alterations, <I>EGFR</I> mutation was significantly associated with the FH-PC (53.8%, 84.1%, and 65.8%, respectively; <I>P</I> = 0.016), <I>ALK</I>/<I>ROS1</I>/<I>RET</I> fusions was significantly associated with the FH-NPC (13.7%, 0.0%, and 5.0%, respectively; <I>P</I> = 0.004), but <I>KRAS</I> mutation was not associated with any type of the FH (13.8% vs. 6.0% vs. 7.8%, respectively; <I>P</I> = 0.288).</P> <P><B>Conclusion</B></P> <P>The type of family history of cancer was associated with distinct clinocogenomic subtypes and prognosis of never-smoker lung adenocarcinoma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Family history of cancer is related to distinct subtypes of never smoker lung cancer. </LI> <LI> <I>ALK/ROS1/RET</I> fusions are enriched in patients with family history of nonlung cancer. </LI> <LI> <I>EGFR</I> mutations are enriched in patients with family history of lung cancer. </LI> <LI> Family history of nonlung cancer is associated with poor prognosis after operation. </LI> </UL> </P>

지속가능한 전력망 점검 스케줄링을 위한 수리계획-발견적 복합 알고리즘

주재관(Jaegwan Joo),노영주(Youngjoo Roh),박현우(Hyunwoo Park),이제리미(Jerimi Lee),이충목(Chungmok Lee) 대한산업공학회 2022 대한산업공학회지 Vol.48 No.1

TIME MONITORING OBSERVATIONS OF SiO J = 2 – 1 AND J = 3 – 2 LINES TOWARD ORION KL

Cho, Se-Hyung,Kim, Hyun-Goo,Chung, Hyun-Soo,Roh, Duk-Gyoo,Kim, Hyo-Ryung,Yun, Youngjoo American Institute of Physics 2010 The Astronomical journal Vol.139 No.1

<P>We have carried out time monitoring observations of the <SUP>28</SUP>SiO v = 0, 1, 2, J = 2 – 1, <SUP>28</SUP>SiO v = 0, 1, 2, J = 3 – 2, and <SUP>29</SUP>SiO v = 0, J = 3 – 2 transitions in Orion KL with the 14 m radio telescope at Taeduk Radio Astronomy Observatory. The pair of J = 2 – 1 and J = 3 – 2 transitions was simultaneously observed from 1999 January to 2001 March. Each transition shows different characteristics. Both the v = 1, J = 2 – 1, and J = 3 – 2 masers show a relatively stable double-peaked profile and little variation in intensity. The <SUP>28</SUP>SiO v = 2, J = 3 – 2 maser presents the most active intensity variations including a disappearance on 2000 February 17 and 2001 February 16. The v = 2, J = 3 – 2 maser may trace the closest region to the central young stellar object and results in the strongest variations of intensity and line profile. The v = 2, J = 2 – 1 maser was not detected in the monitoring. The <SUP>28</SUP>SiO v = 0, J = 3 – 2 lines showed a large variation of peak intensity compared with <SUP>28</SUP>SiO v = 0, J = 2 – 1 that might be due to partial masing. The different observational results of <SUP>28</SUP>SiO v = 0, 1, J = 2 – 1, <SUP>28</SUP>SiO v = 0, 1, 2, J = 3 – 2, and <SUP>29</SUP>SiO v = 0, J = 3 – 2 transitions might reflect that individual transitions trace different portions of gas.</P>

VLBI 관측 데이터의 전송 알고리즘 개발과 서버와 RVDB 사이의 전송 시험

염재환,오세진,노덕규,정동규,오충식,윤영주,김효령,Yeom, Jae-Hwan,Oh, Se-Jin,Roh, Duk-Gyoo,Jung, Dong-Kyu,Oh, Chung-Sik,Yun, Youngjoo,Kim, Hyo-Ryoung 한국융합신호처리학회 2014 융합신호처리학회 논문지 (JISPS) Vol.15 No.4

본 논문에서는 전파천문학에서 초고속 전송망을 위한 관측 데이터의 전송 알고리즘의 개발에 대해 기술한다. 전파망원경으로 관측한 VLBI 데이터 처리를 위한 전처리 과정으로, 데이터 전송 알고리즘은 대용량 스토리지 서버에 저장된 VLBI 데이터를 대전상관기의 동기재생처리장치(RVDB)에 1대 1 방식으로 동작하며 VDIF 규격과 VDIFCP, UDP 프로토콜을 사용한다. 제안방법은 대전상관기의 동기재생처리장치의 데이터 전송을 기다리고 있으면 대용량 스토리지 서버의 Mark5B VSI 규격으로 저장된 2048 Mbps 급 VLBI 관측 데이터를 읽은 후 UDP로 전송하는 방식이다. 제안방법의 유효성을 확인하기 위해 대용량 스토리지 서버와 RVDB OCTADDB 사이에 실제 VLBI 관측 데이터를 전송하고 전송 전후의 데이터에 대해 상관처리 시험을 수행한 후 결과를 비교하였으며, 데이터 전송손실이 없이 전송 전후의 결과가 동일함을 확인하였다. 향후 본 연구에서 개발한 데이터 전송 알고리즘은 KaVA 네트워크에서 e-VLBI로도 유용하게 활용할 수 있을 것으로 기대한다. This paper describes the development of the observational data transmission algorithm for high-speed network in radio astronomy. For the preprocessing of VLBI data observed by radio telescope, data transmission algorithm uses the VDIF specification, VDIFCP, and UDP protocol by transferring VLBI data stored in a massive storage server with one-to-one correspondence between the server and the RVDB of Daejeon correlator. A transmission method is proposed, which reads the recorded data in Mark5B VSI format and trnasmits 2048 Mbps VLBI data by software through UDP packet transmission, while RVDB system is waiting for the transmitting data from the server. In order to check the effectiveness of the proposed method, the data transmission between the massive storage server and RVDB is conducted and the transmitted data is correlated by Daejeon correlator for the accurate comparison concerning the data before and after. The transmitted data is shown to be completely the same as the original data without any data transmission loss. Henceforth, the developed data transmission algorithm in this research is expected to be applied effectively as e-VLBI for KaVA network.