複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

연령집단에 따른 노인의 허약(Frailty) 예측요인 분석

조성은 ( Cho Sung Eun ),최은영 ( Choi Eun Young ),오영삼 ( Oh Young Sam ),김영선 ( Kim Young Sun ),김성복 ( Kim Seong Bok ) 한국보건사회연구원 2017 保健社會硏究 Vol.37 No.3

본 연구의 목적은 연령집단에 따른 허약의 예측요인을 분석하는 것이다. 연구의 목적을 위해 2014년 노인실태조사를 사용하여 총 4,123명을 분석의 대상으로 설정하였다. 허약을 예측하는데 있어 연령의 중요성을 고려하여, 본 연구는 대상자를 75세 이상 85세 미만의 중 고령노인집단(n=3,373명)과 85세 이상의 초 고령노인집단(n=750명)으로 분류하여 연구모형을 검증하였다. 중 고령노인집단에서 전 허약노인과 허약노인은 각각 1453명(약 43%), 1,268명(약 37%)으로 나타났으며, 초 고령노인 집단에서 전 허약과 허약노인은 304명(약 40%), 396명(약 52%)으로 나타났다. 회귀분석의 결과 건강단계에서 허약전 단계로 진입하는 예측요인은 중 고령노인집단에서는 여성, 낮은 교육수준, 많은 만성질환, 낙상 유경험자, 높은 우울, 낮은 인지기능이 허약 전 단계를 예측하는 유의한 변인으로 밝혀졌으며 초 고령노인집단은 여성, 높은 우울, 낮은 사회활동이 유의한 예측요인으로 밝혀졌다. 허약 전 단계에서 허약 단계로의 진입을 예측하는 요인으로는 중 고령노인집단은 여성, 높은 연령, 미취업, 많은 만성질환, 낙상 유경험자, 높은 우울, 낮은 인지기능이 유의한 변인이었으며, 초 고령노인 집단은 높은 연령, 많은 만성질환, 높은 우울, 낮은 인지기능이 유의한 예측요인으로 밝혀졌다. 본 연구는 연령의 세분화와 다각적인 요인의 접근으로 허약의 예측요인을 밝히고자 하였다. 연구를 통해 밝혀진 예측요인은 추후 허약에 대한 다각적 연구의 기초자료로서 활용되리라 기대한다. This study aims to investigate the predictors of frailty in different age groups. To address this purpose, this study used the 2014 Survey of the Living Conditions of the Elderly (SLCE). In the research model, 4,123 older adults aged 75 and older were included from the SLCE. All participants were subdivided into two age groups based on their age; the young old group (75-85) and the old-old group (85+). The young old group consisted of 1,453 (43%) pre-frail older adults and 1,268 (37%) frail older adults; the old-old group consisted of 304 (40%) pre-frail older adults and 396 (52%) frail older adults. Our regression analysis showed that in the young-old, being female, lower levels of education, having more chronic diseases, having fall experience, higher depression, lower cognitive functioning significantly predicted transition to pre-frailty from non-frail status. In the old-old, being female, higher depression, lower level of social activity were significant predictors. On the other hand, predictors of transition to frailty from pre-frail status in the young-old were being female, higher age, being unemployed, having more chronic diseases, having fall experience, higher depression, lower cognitive functioning. In the old-old, predictors of transition to frailty from pre-frail status were only higher age, having more chronic disease, higher depression, and lower cognitive functioning. The research findings can be used as a reference point in the making of strategies for preventing frailty.

노년기 주관적 연령과 건강노화와의 관계: 연령집단별 분석

최은영 ( Choi Eun Young ),조성은 ( Cho Sung Eun ),오영삼 ( Oh Young Sam ),장희수 ( Chang Hee Su ),김영선 ( Kim Young Sun ) 한국보건사회연구원 2017 保健社會硏究 Vol.37 No.1

본 연구의 목적은 노년기 주관적 연령(스스로를 노인 혹은 비(非)노인으로 인지하는지 여부)과 건강노화와의 관계를 연령집단에 따라 검증하는 것이다. 이를 위해 2014년 노인실태조사 대상자 중 연소노인(65~74세)과 고령노인(75~84세)을 연구대상으로 선정하였다. 연구의 주목적인 주관적 연령과 건강노화 간의 관련성을 검증하기 위해 연소노인 및 고령노인 집단별로 다중회귀분석(multiple regression analysis)을 실시하였다. 연구결과, 주관적 연령과 건강노화의 관계는 연령집단별로 다른 양상을 보이는 것으로 나타났다. 연소노인에서 주관적 연령이 비(非)노인인 경우, 높은 수준의 인지기능과 적은 만성질환 수, 낮은 수준의 우울, 그리고 높은 수준의 사회활동 참여를 보이는 것으로 밝혀졌다. 반면, 고령노인인 경우 주관적 연령은 인지기능을 제외하고 건강노화의 다른 세 요소와 유의미한 관련이 없었다. 본 연구는 주관적 연령을 건강노화의 새로운 고려요소로 제시하여, 두 요소의 관련성을 통합적인 차원에서 살펴보았다는 의의가 있다. 또한 노인을 연령대에 따라 구별된 집단으로 살펴봄으로써, 주관적 연령과 건강노화의 연관성이 연령집단마다 상이한 양상을 보임을 밝혔다는 의의를 가진다. The purpose of this study is to examine the relationship between subjective age (whether one subjectively perceives himself as `the elderly` or `not the elderly`) and healthy aging. Using data from the 2014 National Elderly Survey (KIHASA), this study selected a total of 9,653 participants consisting of young-olds (aged 65-74) and old-olds (aged 75-84) For both the young-old and the old-old, multiple regression analyses were conducted to examine the research model. In the young-old population, one`s considering oneself as “non-elderly” was significantly associated with higher cognitive functioning, fewer chronic diseases, lower depressive symptoms, and higher level of social engagement. On the other hand, in the old-old population, one`s considering oneself as “non-elderly” was associated only with higher cognitive functioning, and not with the other domains of healthy aging. The findings suggest that subjective age can be considered as an important predictors of older adults` healthy aging. These findings indicate that the association between subjective age and healthy aging has a different pattern depending on the age group.

적층고무 받침을 사용한 강상형교의 시공단계별 대기온도변화에 따른 Steel Box의 실제 온도에 관한 연구

조동영,유희중,임삼규 호남대학교 2003 호남대학교 학술논문집 Vol.24 No.2

이단평행봉 위 공중돌아 내리기 동작의 운동학적 분석

조태호,주영삼 경희대학교 체육과학연구소 1995 體育學論文集 Vol.23 No.-

In an attempt to investigate the difference between once and twice in back tumbling shown In the process of touching the down bar In girl's parallel bars in the field of heavy gymnastics, we selected three gymnastic girl players as subject, and analyzed them, by way of 16mm high-speed camera on the photography of 50 fram/sec. We came to a conclusion as follows; 1.For a position change in the center of body, the distance of horizontla and vertical movement didn't make a great difference. 2.For a speed change on the center of body, the turn around twicee was not show more more rapidly than that once until becoming the stage of seperating hands from bar, and both of tumbling were shown fast at the them of landing, making a defective factors scores. 3.In the process of performing a great revolution the bar called "Taecha", the angle of a shoulder joints did not maintain 180 degrees, making defective factors on scores. 4.In the process of tumbling in the air, the angle of the main joint was not completely flexed in both revolution, making an unfavorable factors on scores. 5.In the process of a great revolution in the bar, it look less time for a turn around twice than that once where as a certain pattern was not shown In the totally consuming time.

흉배혈관의 근피 천공분지에 기초한 유리피판의 임상적 이용

조규성,김대영,안호범,이삼용,조백현 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

The latissimus dorsi muscle or musculocutaneous flap is one of the most useful flaps in reconstructive surgery. This flap has many advantages, such as its reliable anatomy, long pedicle with large caliber vessels, minimal functional deficit of the donor site, and low incidence of donor site complications. However, the bulkiness of the flap has been considered a disadvantage, so various modifications of technique have been devised. The cutaneous portion of the flap can be safely elevated based on the cutaneous perforating branch of the thoracodorsal vessel. From March 1997 to February 1998, 10 patients underwent reconstructive procedures with thoracodorsal perforator-based free flaps. The composition of the flaps varied in accordance with the nature of the defect. The variances in the flaps were as follows; 3 were cutaneous, 6 musculocutaneous, and 1 osteomusculocutaneous including the rib. All flaps survived with good contour. We concluded that this thin and reliable flap was useful for reconstruction of various defects, and that the composition of the flap, such as subcutaneous, muscle and bone, gave it considerable flexibility as needed.

고등학교 지구과학Ⅰ '살아있는 지구 - 지각변동' 단원의 용어 비교 분석

조영삼,김종헌 공주대학교 과학교육연구소 2004 과학교육연구 Vol.35 No.-

7차 교육과정에 의해 만들어진 고등학교 지구과학 Ⅰ의 “살아있는 지구-지각변동” 단원에 나와있는 단어와 용어들을 비교·분석하였다. “살아있는 지구-지각변동” 단원에서 사용되고 있는 단어의 총 수는 97개이나, 주로 사용되는 18개의 용어들을 선정하여 개념수준과 인지수준을 비교·분석하였다. 이들 단어들의 명확도는 조작적 정의에 의해 전문가들의 평가를 받아 이루어졌다. 난이도의 수준은 고등학교 1학년 수준이며 개념수준과 인지수준은 교과서별로 약간의 차이가 있다. The terminology used in unit Ⅱ “The Earth is alive-crustal movement” in the textbook of ‘Earth Science Ⅰ’for High School based on 7th Educational Curriculum, were compared. Among 97 terminology used in the unit “The Earth is alive-crustal movement”, 18 terminology which are frequently used, are chosen to be analyzed its level of concept and recognition. The degree of clearness of the terms is made by experts' operation definition. The standard of hardness is taken to the level of 1st year High School students. The concept and recognition levels used in four textbooks are some different from each other.

地方自治에 있어서의 地域開發과 環境保全方案에 관한 硏究 : Cheju Province Case 濟州道를 中心으로

趙文富,韓三寅,玄榮珍 濟州大學校 地域社會發展硏究所 1996 社會發展硏究 Vol.12 No.-

沙上地域 産業體 勞動者의 職場體育 參與擴大 方案

安永弼,鄭琮勳,鄭三鉉,金海禮,趙在基,朴俊東,金垠利,張禎允,金福善,孔庚鎬 東亞大學校附設스포츠科學硏究所 1989 스포츠科學硏究論文集 Vol.7 No.-

하비도 외측벽에서 발견한 상악동 부공 1례

유영삼,우훈영,조경래,최정환 인제대학교 2008 仁濟醫學 Vol.29 No.-

An accessory ostium can be found in the posterior fontanelle of the maxillary sinus during endoscopic examination of the nasal cavity in approximately one quarter of patients. It is not uncommon to find an accessory ostium in a CT scan. Recently, we removed a polyp from inferior meatus of a thirteenyears old girl. After polypectomy, we found accessory ostium of maxillary sinus in the inferior meatus. As far as we know, this is the first case of ectopic accessory ostium of maxillary sinus.