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- 저자 : Youn Yeo-Dong (검색결과 154 건)
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강산 및 강알칼리 음독에서 냉각 용액을 사용한 희석 요법과 중화 요법의 가능성
이중의,송형곤,김동훈,권운용,곽영호,서길준,윤여규 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: There is no effective treatment modality for caustic agent ingestion. Dilution and neutralization are prohibited because of the risk of secondary thermal injury. This experiment is designed to evaluate the amount of dilution and neutralization heat and to gauge the applicability of dilution and neutralization therapy using cold solutions to suppress the peak temperature. Methods: This is an in-vitro chemical experiment. HCl, CH3COOH, NaOH, and NH4OH are selected as representatives of strong and weak acids and strong and weak alkali, respectively. 20℃, 11.6M, 5.8M, and 2.9M solutions of each acid and alkali are made and mixed using a magnetic stirrer at a room air temperature of 28℃. The peak temperature, the duration above 40℃, and the heat amount are measured or calculated. Results: When a 11.6M HCl or NaOH solution is diluted with same amount of water, 32 or 18cal. per mL of HCl or NaOH is produced, respectively. HCl produces a significant peak temperature, but NaOH does not. The lower the concentration, the lower the amount of heat production. 11.6M CH3COOH and NH4OH solutions don't produce dilution heat.11.6M and 5.8M solutions of all acids and alkali produce destructive neutralization heat. However, 2.9M solutions produce neutralization heat which might be controllable. When a 11.6M HCl or NaOH solution is neutralized with a -10℃ 2.9 M NaOH or HCl solution, respectively, the peak temperature produced is below 40℃ and seems to add little thermal damage to viable tissue. Conclusion: Dilution and neutralization with a cold solution in cases of strong acid or alkali ingestion is a promising method to avoid thermal injury.
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In-depth considerations for better polyelectrolytes as interfacial materials in polymer solar cells
Yeo, Jun-Seok,Kang, Minji,Jung, Yen-Sook,Kang, Rira,Lee, Seung-Hoon,Heo, Youn-Jung,Jin, Sung-Ho,Kim, Dong-Yu,Na, Seok-In Elsevier 2016 Nano energy Vol.21 No.-
<P><B>Abstract</B></P> <P>We perform a comprehensive study to achieve better polyelectrolytes (PEs) as electron-transport layers (ETLs) in polymer solar cells (PSCs). Three well-known PEs – PFN, PEIE, and WPF – are chosen as model systems and investigated with variations in their backbone structures and the state of the amine functionalities on their side chains. Respectively optimized PSCs using the three PEs exhibit different cell-performances, mainly owing to the diode characteristics of built-in potential and recombination strength. To identify how such deviated device-performances correlate with the structural features of PEs, the modulated interfaces of ITO/PEs and PEs/active layer are studied in detail. It is found that conjugated backbones and larger counter-anions on side chains can promote the modulation of ITO work functions (WFs) and that a large amount of protonated amines on PEs is beneficial for junction properties with a subsequent active layer. Additionally, our results indicate that interfacial dipole and electrical doping between the PE and active layer, in addition to WF modulation of the ITO cathode, are important for device efficiency. Accordingly, with the aid of the molecular features of PEIE, PEIE-PSCs exhibit excellent device efficiency and stability compared with PFN- and WPF-PSCs. In the PTB7-th:PC<SUB>71</SUB>BM system, a remarkable power-conversion efficiency of 9.97% is achieved with a single PEIE ETL.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Chemical structure and performance of polyelectrolytes (PEs) in PSCs are correlated. </LI> <LI> Interfacial dipole and doping between PEs and active layer lead to efficient PSCs. </LI> <LI> PEIE-based PSCs have excellent device efficiency and high stability. </LI> <LI> Especially, in the PTB7-th system, encouraging efficiency of 9.97% is achieved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Yeo, Min-kyung,Bae, Ja Seong,Lee, Sohee,Kim, Min-Hee,Lim, Dong-Jun,Lee, Youn Soo,Jung, Chan Kwon Hindawi Publishing Corporation 2015 International Journal of endocrinology Vol.2015 No.-
<P><I>Background</I>. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear. <I>Methods</I>. Of the 2,139 patients who underwent surgical treatment for PTC from 2012 to 2013, 40 patients with WLPTC were identified and compared to 200 consecutive patients with classic PTC. <I>BRAF</I> mutation was tested with pyrosequencing. <I>Results</I>. There were no significant differences in age, predilection for women, multifocality, extrathyroidal extension, or lymph node metastasis between WLPTC and classic PTC. However, WLPTCs were more commonly associated with Hashimoto's thyroiditis than classic PTCs (93% versus 36%, resp., <I>P</I> < 0.001) and showed significantly lower rate of <I>BRAF</I> mutation when compared to classic PTCs (65% versus 84%, resp., <I>P</I> = 0.007). In classic PTC, the frequency of <I>BRAF</I> mutations was negatively correlated with coexisting Hashimoto's thyroiditis. When we compared WLPTC and classic PTC in the patients with coexisting Hashimoto's thyroiditis, there were no significant differences in clinicopathologic characteristics or the <I>BRAF</I> mutational rate between the two groups. <I>Conclusions</I>. Patients with WLPTC have similar demographic, clinical, pathologic, and molecular characteristics to those with classic PTC coexisting with Hashimoto's thyroiditis.</P>
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The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis
Yeo, Marie,Mi Na, Young,Kyu Kim, Dong,Bae Kim, Young,Jeong Wang, Hee,Lee, Jung A.,Youn Cheong, Jae,Jae Lee, Kwang,Paik, Young-Ki,Won Cho, Sung WILEY-VCH Verlag 2010 Proteomics Vol.10 No.2
<P>Biomarkers for the detection of early hepatocellular carcinoma (HCC) are urgently needed. To identify biomarkers of HCC, we performed a comparative proteomics analysis, based on 2-DE of HCC tissues and surrounding non-tumor tissues. Six xenobiotic enzymes were significantly down-regulated in the HCC tissue. Among these, phenol sulfotransferase (SULT1A1) was confirmed by Western blot analysis in 105 HCC patients. SULT1A1 showed a significant decrease in 98.1% of the HCC tissues, with 88.6% sensitivity and 66.7% specificity for the detection of HCC. Immunohistochemistry for SULT1A1 was performed and compared with glypican-3, which is a well-known marker of HCC. The results showed down-regulation of SULT1A1 and up-regulation of glypican-3 in 52.6 and 71.9% of the HCCs, and the use of both markers improved the sensitivity up to 78.9%. Moreover, SULT1A1 was useful in differentiating early HCC from benign dysplastic nodules. Clinically, the down-regulation of SULT1A1 was closely associated with an advanced International Union Against Cancer stage and high levels of serum α-fetoprotein. In conclusion, the results of this study demonstrate that the loss of SULT1A1 appears to be a characteristic molecular signature of HCC. SULT1A1 might be a useful biomarker for the detection of early HCC and help predict the clinical outcome of patients with HCC.</P>
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Yeo, Eui-Joo,Kim, Hyun-Wook,Hwang, Ko-Eun,Song, Dong-Heon,Kim, Yong-Jae,Ham, Youn-Kyung,He, Fu-Yi,Park, Jae-Hyun,Kim, Cheon-Jei Korean Society for Food Science of Animal Resource 2014 한국축산식품학회지 Vol.34 No.4
Duck feet gelatin (DFG) gel was added as a fat replacer to low-fat frankfurters and the effect of DFG on physicochemical, textural, and sensory characteristics of low-fat frankfurters was evaluated. DFG gel was prepared with a 20% duck feet gelatin concentration (w/w). Adding DFG decreased lightness and increased yellowness of the low-fat frankfurters (p<0.05). However, DFG did not affect redness of low-fat frankfurters (p>0.05). The statistical results indicated that adding DFG improved cooking yield of low-fat frankfurters (p<0.05). In addition, replacing pork back fat with DFG resulted in increased moisture content, protein content, and ash content of low-fat frankfurters, and the low-fat frankfurter formulated with 5% pork back fat and 15% DFG gel had the highest moisture content and lowest fat content (p<0.05). Adding of DFG increased all textural parameters including hardness, springiness, cohesiveness, chewiness, and gumminess of low-fat frankfurters (p<0.05). In terms of sensory properties, the low-fat frankfurter formulated with 5% pork back fat and 15% DFG gel showed similar satisfaction scores for the flavor, tenderness, juiciness, and overall acceptance when compared to the regular frankfurters (20% back fat). Therefore, our results suggest that DFG could be an effective novel source, as a fat replacer, for manufacturing of low-fat frankfurters.
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Youn-Sun Lee,Jae-Myung Yoo,Hyun-Woo Shin,Dong-Hyun Kim,Yong-Moon Lee,Yeo-Pyo Yun,Jin-Tae Hong,Seikwan Oh,Hwan-Soo Yoo 고려인삼학회 2006 Journal of Ginseng Research Vol.30 No.1
Ceramide has been involved in cell death and acted as a lipid mediator of stress responses. Elevation of ceramide level was reported to occur in oxidative stress and lead to cell death in many cell types. This study was undertaken to elucidate a protective role of ginsenoside Rg1 in cell death induced by oxidative stress. When LLC-PK1 cells were treated with H₂O₂ at a concentration of 400 μM for 5 hr, cell death was observed and a released LDH activity indicative of cytotoxicity was increased. H₂O₂ exposure to LLC-PK1 cells was shown to elevate the content of total ceramide by approximately 200% compared to control cells. Ceramide level was hypothesized to be a key to a reversal of cell death to survival. Ginsenoside Rg1 at the concentrations ranging from 12.5 to 250 μM protected LLC-PK1 cells from cell death induced by H₂O₂ at 400 μM for 5 hr, and decreased the ceramide level relative to H₂O₂. Ginsenoside Rg1 inhibited neutral human ceramidase by 71% of controls, while sphingomyelinase was not inhibited. These results suggest that ginsenoside Rg1 show the protection against cell death via the modulation of ceramide metabolism, and ceramide may be a promising therapeutic target for human diseases related to cell death.
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Yeo, Marie,Park, Hee Jin,Kim, Dong-Kyu,Kim, Young Bae,Cheong, Jae Youn,Lee, Kwang Jae,Cho, Sung Won Wiley Subscription Services, Inc., A Wiley Company 2010 Cancer Vol.116 No.11
<B>BACKGROUND:</B><P>We previously found the down-expression of SM22 in an experimental animal model of colorectal cancer by performing a proteomic analysis. In this study, we addressed the expression and molecular mechanisms of SM22 in human colorectal cancer.</P><B>METHODS:</B><P>To evaluate the expression of SM22 in colon cancers, Western blot and immunohistochemistry were performed in 13 normal, 14 adenomas, and 44 adenocarcinomas. To address the role of SM22 in colon carcinogenesis, SM22 was restored in the colon cancer cells by the transfection with the pIRES2 vector containing full-length SM22 cDNA and tested for tumorigenicity in vivo and in vitro.</P><B>RESULTS:</B><P>SM22 was found to be significantly down-regulated in adenocarcinoma (58%) compared with adenoma (21.4%) and normal (15.3%). The loss of SM22 correlated with poor differentiation of tumor (P = 0.009) and lymph node metastasis (P = 0.029). Restoration of SM22 expression inhibited cell migration, colony-forming ability of cancer cells, and induced retardation of in vivo tumor growth in a xenograft model.</P><B>CONCLUSIONS:</B><P>Loss of SM22 is a molecular signature of colon cancer and is closely associated with progression, differentiation, and metastasis of colon cancer. The restoration of SM22 leads to an inhibition of colon carcinogenesis in vivo and in vitro, suggesting that SM22 might potentially function as a novel tumor suppressor. Cancer 2010. © 2010 American Cancer Society.</P>
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Dong Sik Bae,Jung-Woo Woo,Se Hyun Paek,Hyungju Kwon,Young Jun Chai,Su-jin Kim,June Young Choi,Kyu Eun Lee,Yeo-Kyu Youn 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.5
Purpose: A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the antiadhesive effect and safety of HA-CMC membrane in thyroidectomy for papillary thyroid cancer. Methods: One hundred sixty-two patients who underwent thyroidectomy were prospectively randomized. In the study group of 80 patients, the 7.5 cm × 13 cm HA-CMC membrane was applied to the operative field after thyroidectomy. The subjects were asked about complications including adhesive symptoms using an 8-item questionnaire at 2 weeks, 3 months, and 6 months after surgery. In addition, items on the appearance of neck wrinkles and scars were evaluated by a physician who had no information about the patient’s allocation. Results: There were no significant differences in complications such as swallowing difficulty, and wrinkles between study and control groups. Both groups presented significantly decreased scores over time in swallowing difficulty, and wrinkles. There were no complications regarding the HA-CMC membrane. Conclusion: The antiadhesive effect of HA-CMC membrane in thyroid surgery is still uncertain, although it is biologically safe. Further investigation is needed to confirm the antiadhesive effect of HA-CMC membrane in thyroid surgery.
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