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박규영,박모라,서수경,손순희,정경희,정유선 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-
대구 시내 전역에 산재해 있는 튀김 음식점과 스넥코너등에서 튀김중인 기름에 대한 변패도를 알아 보기 위해 여름철과 겨울철 두 계절에 또 튀김물의 종류별로 시료 186개를 채취하여 산가, 과산화물가, carbonyl가 및 TBA가를 측정한 결과는 아래와 같다. 1. 산가, 과산화물가, carbonyl가 및 TBA가는 각각 2.2, 47, 19, 0.7로 나타났다. 2. 여름철로가 겨울철을 비교해 본 결과는 산가, 과산화물가, carbonyl가는 여름철이 높았으나 TBA가는 두 계절이 비슷하였다. 3. 튀김물의 종류에 따른 기름의 변패도는 오뎅, 핫도그, 닭, 야채, 도나스 순으로 나타났다. In order to investigate the degree of changes in quality of frying oils to be used atsnack corners and street stalls in Taegu area. acid value (AV), peroxide value(POV), carbonyl value (COV), and TBA value were measured. 95 samples insummer and 91 samples in winter were collected from oils fried for fish cake, hotdogs,chicken, vegetable and doughnuts. The mean value of AV, POV and COV on the fryingoils collected in summer were higher than those in winter, while TBA value of oilsin summer ·was similar to that in winter. According to the kinds of fried food, thedegree of the change in quality of frying oil was high in order of fish cake, hotdog,chicken, vegetable ana doughnut.
Park, You-Soo,Bae, Jae-Ho,Son, Cheol-Hun,Lee, Kyung-Soo,Kim, Wontaek,Jung, Min Ho,Yang, Kwangmo,Kim, Sun-Hee,Kang, Chi-Dug Informa Healthcare 2011 Immunological investigations Vol.40 No.4
<P>Growth of a tumor on the left flank was suppressed by direct injection of immature DCs (iDCs) into the irradiated tumor on the right thigh (IR//DC). This antitumor immune effect of IR//DC was enhanced by pretreatment with CTX (CTX++IR//DC) and this effect was related with increased number of tumor-specific IFN-γ款 secreting T cells and decreased ratio of CD4<SUP>++</SUP>CD25<SUP>++</SUP>//CD4<SUP>++</SUP> T cells. The treatment with CTX++IR//DC increased or decreased the levels of IL-2 or IL-10, respectively. These results demonstrated that antitumor effect of IR//DC could be augmented by pretreatment with low-dose CTX, suggesting a new antitumor therapeutic modality of chemoradioimmunotherapy.</P>
Son, Cheol-Hun,Bae, Jae-Ho,Shin, Dong-Yeok,Lee, Hong-Rae,Yang, Kwangmo,Park, You-Soo Informa Healthcare USA, Inc. 2014 Immunological investigations Vol.43 No.5
<P>Various <I>ex vivo</I> or <I>in vivo</I> loading protocols have been developed or evaluated for the delivery of tumor antigens to dendritic cells (DCs). We compared the antitumor effect of mature DCs electroporation-pulsed (EP/mDC) <I>ex vivo</I> with tumor cell lysate and immature DCs (iDCs) injected into the tumor apoptosed by ionizing radiation (IR/iDC) in lung cancer model. DCs were generated from bone marrow of C57BL/6 mice. Ionizing radiation (IR) was applied at a dose of 10 Gy to the tumor on the right thigh. iDCs were intratumorally injected into the irradiated tumor and EP/mDC was injected subcutaneously in the right flank. DC injection induced strong tumor-specific immunity against Lewis lung carcinoma, as compared with the tumor-bearing control and IR only treated mice. The growth of a distant tumor on the right and left flank was inhibited by IR/iDC and EP/mDC. Particularly, IR/iDC resulted in a more significant inhibition of tumor growth and prolonged survival time. It was related to increase of tumor-specific interferon-gamma, cytotoxicity, and decrease of regulatory T-cells. The results indicate that DCs electroporation-pulsed with tumor cell lysate induce a potent antitumor effect, but that iDCs intratumoral injected into the irradiated tumor induce a more potent antitumor effect.</P>
Son, Cheol-Hun,Bae, Jae-Ho,Shin, Dong Yeok,Lee, Hong-Rae,Choi, Yung Hyun,Yang, Kwangmo,Park, You-Soo Informa Healthcare 2013 Immunological investigations Vol.42 No.4
<P>Dendritic cells (DCs) are potent antigen-presenting cells that can be matured <I>in vitro</I> from immature dendritic cells (iDCs) in the presence of several biological agents such as cytokine cocktail, CD40L, TNF-a and antigen loading, which are necessary and achieved using various protocols, such as lipofection, passive pulse or electroporation. However, these DCs maturation protocols may cause with a significant loss of cells because of cellular attachment and spreading during culturing. Some biomaterials that influence adhesion and development of cells have been used in cell culture techniques, and it was thought that they might be applied on the culture of DCs. In this study, we used polyHEMA, which is a hydrogel coating biomaterial that prevents DCs from adherence, and investigated whether hydrogel coating affects the maturation of iDCs. The efficiency in the generation of mDCs was improved through hydrogel coating procedure and a dendritic cell maturation marker, CD83, was significantly increased in hydrogel-coated culture condition. The antigen-loaded mDCs from electroporation were further expressed the CD83. The mDCs generated in the hydrogel-coated culture condition showed more, longer and thicker dendrites, and produced more amounts of cytokines such as IL-12 and IFN-γ. Therefore, it was suggested that the hydrogel-coated culture condition could improve function of mDCs.<fn><P>Cheol-Hun Son and Jae-Ho Bae contributed equally to this work.</P></fn></P>
Son, Cheol-Hun,Bae, Jae-Ho,Lee, Hong-Rae,Shin, Dong-Yeok,Yang, Kwangmo,Park, You-Soo Lippincott-Raven 2015 Journal of immunotherapy Vol.38 No.3
<P>Regulatory T cells (Tregs) is one of the main obstacles to the success of cancer immunotherapy. The effect of dendritic cell (DC)-based immunotherapy can be attenuated by immune suppressive functions of Tregs. We used a CD25-targeted antibody and low-dose cyclophosphamide (CTX) as immunomodulators to increase the antitumor effect of intratumoral injection of immature DCs into the irradiated tumor cells (IR/iDC). CTX or CD25-targeted antibody alone showed a significant reduction in the number of Tregs within the tumor microenvironment. When they are combined with IR/iDC, the number of Tregs was further reduced. Although IR/IDC showed strong antitumor effects such as reduction in tumor growth, increase in Th1 immune response, and improvement of survival, the therapeutic effect was further improved by combining treatments with immunomodulators. CTX and CD25-targeted antibody showed no significant difference in tumor growth when combined with IR/iDC, but CTX further increased the number of interferon (IFN)--secreting T cells, cytotoxicity, and survival rate. Although irradiation induced depletion of T lymphocytes, administration of DCs recovered this depletion. Particularly, the lymphocytes were more significantly increased when CTX and IR/iDC were combined. Low-dose CTX has already been used as an immunomodulator in clinical trials, and it offers several advantages, including convenience, low-cost, and familiarity to clinicians. However, CD25-targeted antibody cannot only deplete Tregs, but also may affect IL-2-dependent effector T lymphocytes. Therefore, CTX is an effective means to inhibit Tregs, and an effective immunomodulatory agent for multimodality therapy such as combination treatment of conventional cancer therapy and immunotherapy.</P>
유성수,권현희,박경찬,윤현대,이지현,손호상 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.3
저자들은 전신 쇠약감을 주소로 내원 한 환자에서 흑색극세포증과 당뇨병성 케톤산혈증이 동반된 1예를 경험하였기에 이를 문헌 고찰과 함께 보고한다. Acanthosis nigricans is a skin lesion characterized by localized areas of brown hyperpigmented and velvety hyperplastic skin. Typically, it is found at body folds such as the neck and axilla. This condition is frequently accompanied by insulin resistance, hyperinsulinemia and obesity or it may be a signal of underlying malignant disorder, such as gastric cancer. Although diabetic ketoacidosis may develop in patients with type 2 diabetes when they experience severe metabolic stress, it usually occurs only in individuals whose circulating insulin is virtually absent. Because acanthosis nigricans is seen in insulin-resistant states or hyperinsulinemic states, patients with acanthosis nigricans are not likely to develop diabetic ketoacidosis. Because of the unexpected occurrence of diabetic ketoacidosis in association with acanthosis nigricans, we report this case.