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Peter Stanford Kirk,Yooni Yi,Miriam Hadj-Moussa,Bahaa Sami Malaeb 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.3
Purpose: Lichen sclerosus (LS) in men is poorly understood. Though uncommon, it is often severe and leads to repeated surgical interventions and deterioration in quality of life. We highlight variability in disease presentation, diagnosis, and patient factors in male LS patients evaluated at a tertiary care center. Materials and Methods: We retrospectively reviewed charts of male patients presenting to our reconstructive urology clinic with clinical or pathologic diagnosis of LS between 2004 and 2014. Relevant clinical and demographic information was abstracted and descriptive statistics calculated. Subgroup comparisons were made based on body mass index (BMI), urethral stricture, and pathologic confirmation of disease. Results: We identified 94 patients with clinical diagnosis of LS. Seventy percent (70%) of patients in this cohort had BMI >30 kg/m2, and average age was 51.5 years. Lower BMI patients were more likely to suffer from urethral stricture disease compared to overweight counterparts (p=0.037). Patients presenting with stricture disease were more likely to be younger (p=0.003). Thirty percent (30%) of this cohort had a pathologic diagnosis of LS. Conclusions: Urethral stricture is the most common presentation for men with LS. Many patients endure skin scarring and have numerous comorbidities. Patient profile is diverse, raising the concern that not all patients with clinical diagnosis of LS are suffering from identical disease processes. The rate of pathologic confirmation at a tertiary care institution is alarmingly low. Our findings support a role for increased focus on pathologic confirmation and further delineation of the subtype of disease based on location and clinical manifestations.
Chu, Jia-Qi,Kim, Su-Mi,Lee, Kwang-Nyeong,Oem, Jae-Ku,Ko, Young-Joon,Lee, Hyang-Sim,Kim, Yong-Joo,Park, Jee-Yong,Kim, Kwang-Jae,Parida, Satya,Oh, Yooni,Paton, David J.,Joo, Yi-Seok,Kim, Byounghan,Park, The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.3
Interferon is an important cytokine that plays a critical role in the initial host defense against viral infection. Recombinant human adenoviruses expressing human interferon-${\alpha}$ (Ad-$HIFN{\alpha}$) or pig interferon-${\beta}$ fused with interleukin-18 (Ad-$PIFN{\beta}$-IL18) were constructed and used to induce an early protective response against foot and mouth disease (FMD). To analyze the antiviral effect, bovine thyroid and porcine kidney IBRS-2 cells and ICR mice were treated with Ad-$HIFN{\alpha}$, Ad-$PIFN{\beta}$-IL18, and cocktail of Ad-$HIFN{\alpha}$ and Ad-$PIFN{\beta}$-IL18. The survival rate of suckling mice was monitored after foot and mouth disease virus (FMDV) challenge following intra-peritoneal (IP) administration of appropriate adenovirus. Indirect antigen ELISA was performed to evaluate inhibition of FMDV replication following challenge with the FMDV O, A, or Asia 1 serotypes in vitro. These recombinant adenoviruses reduced the replication of FMDV in susceptible cells, thereby decreasing the fatality in mice, suggesting that they can be a useful control method for the early protection against FMD infection in livestock after field trial.