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유레아 및 티오유레아 유도체의 합성과 활성화된 대식세포의 NO 생성 저해효과
김윤정,천예진,임효진,류재하,전라옥,Kim, Yoon-Jung,Cheon, Ye-Jin,Lim, Hyo-Jin,Ryu, Jae-Ha,Jeon, Ra-Ok 대한약학회 2007 약학회지 Vol.51 No.4
Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value.
성문상부 종물 양상의 일차성 후두 Large B세포 림프종 1예
김승우(Seung Woo Kim),김윤정(Yoon Jung Kim),김춘동(Choon Dong Kim),최전하(Jeon Ha Choi) 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.1
The extranodal non-Hodgkin lymphoma is uncommonly occurred in larynx, accounting for less than 1% of all laryngeal neoplasm. In general, the laryngeal lymphoma is appeared as submucosal mass without mucosal ulcer-ation and is most commonly found in supraglottis. The primary laryngeal lymphoma constitute a diagnostic chal-lenge because they are characterized by absence of clinical and gross differential criteria, compared with squamous cell carcinoma (SCC). We encountered a 74-year-old man with hoarseness and lump sensation in the throat. On di-rect laryngoscope, multiple ulcerative and exudative mass in glottis and supraglottic areas were observed. The pa- tient was finally diagnosed as large B-cell lymphoma through the laryngeal microsurgery. He received radiation therapy and there is no evidence of recurrence. Although the laryngeal mass has superficial mucosal change, pri- mary laryngeal lymphoma must be included in the differential diagnosis.
무통성 결절 양상의 갑상선에 발생한 만성 육아종성 염증 1예
곽슬기(Seul Gi Kwak),최전하(Jeon Ha Choi),김윤정(Yoon Jung Kim),김승우(Seung Woo Kim) 대한두경부종양학회 2013 대한두경부 종양학회지 Vol.29 No.2
Some clinical diseases, such as granulomatous thyroiditis, tuberculosis, and sarcoidosis can cause granuloma-tous inflammation in thyroid, and theses have various clinical presentations. Granulomatous thyroiditis is an in-flammation of thyroid gland, and may be painful and tender in case of infection, radiation, or trauma. Otherwise, autoimmune conditions, medications, or an idiopathic fibrosis may cause to be a painless thyroididtis. It is self-limited, possibly viral, inflammatory thyroid disorder usually presented with thyroid pain and systemic symp-toms. Tuberculosis of the thyroid occurs only rarely and the patient may be asymptomatic. In thyroid sarcoidosis, most common findings are painless, progressive enlargement of the thyroid with normal function. We have expe-rienced a case of chronic granulomatous inflammation of thyroid gland presenting as a painless thyroid nodule and report it with a review of literature.
PPAR의 리간드로서 새로운 요소 유도체의 분자설계 및 합성
김윤정,전라옥 숙명여자대학교 약학연구소 2006 약학논문집-숙명여자대학교 Vol.23 No.-
PPAR is one of the significant drug targets and activation of PPAR □ by several thiazolidinedione derivatives is well established. Herein bioisosteric replacement of thiazolidinedione to urea was carried out. Non-thiazolidinedione derivatives, [4-(2-carbazol-9-ylethoxy)phenyl]ureas (5, 6) were designed and synthesized to obtain novel PPAR activators.