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Jun, Yongseok,Park, Jong Hyeok,Kang, Man Gu The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.52
<P>The tubular-shaped nanostructure of TiO<SUB>2</SUB> is very interesting, and highly ordered arrays of TiO<SUB>2</SUB> nanotubes (TNTs) can be easily fabricated by anodization of the Ti substrate in specific electrolytes. Here in this feature article, we review synthesis methods for various TNTs including normal, alloy, and architectural forms such as bamboos, lace, and flowers. Specific nanosize architectures such as bamboo and lace types can be regulated by alternating voltage and further anodizing. In order to extend light response of TNTs to visible solar spectra, various dopings of specific elements have been discussed. The normal and modified TNTs are suggested for applications such as dye sensitized solar cells, water splitting, photocatalytic degradation of pollutants, CO<SUB>2</SUB> reduction, sensors, energy storage devices including Li ion batteries and supercapacitors, and other applications such as flexible substrate and biomaterials.</P> <P>Graphic Abstract</P><P>This article summarizes the preparation methods for various TiO<SUB>2</SUB> nanotubes by anodization and their applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc30733b'> </P>
( Yongseok Kim ),( Dawon Jeong ),( Hophil Min ),( Changmin Sung ),( Ju-hyung Park ),( Junghyun Son ),( Kang Mi Lee ),( Ho Jun Kim ),( Jaeick Lee ),( Oh-seung Kwon ),( Ki Hun Kim ) 한국질량분석학회 2017 Mass spectrometry letters Vol.8 No.2
Meldonium is a drug for treating ischemia by expanding the arteries but it can also enhance the performance of sports players. The World Anti-Doping Agency (WADA) has included it in the list of prohibited substances since 2016. Meldonium is one of the challenging substances for anti-doping testing because it is difficult to recover by general liquid-liquid or solid phase extraction due to its permanent charge and high polarity. Therefore, high-performance liquid chromatography (HPLC) is cur-rently used by injecting a diluted urine sample (known as the “dilute-and-shoot” strategy). There is no loss of target compounds in the extraction/cleanup procedure but its high matrix effect could interfere in their separation or detection from the endogenous urinary compounds. We report a single method using high-resolution mass spectrometry that can be used for both screening and confirmation, which follows the “dilute-and-shoot” strategy. In this method, the endogenous compounds` interfering peaks in the mass spectrum are separated at a high resolution of FWHM 140,000, and the results are suitable for substance detection follow-ing the WADA guidelines. The interferences in the obtained mass spectrum of the urine matrix are identified as acetylcholine, lysine, and glutamine by further analysis and database searching. Validation of the method is performed in routine anti-doping testing, and the limit of detection is 50 ng/mL. This method uses simple sample preparation and a general reverse phase HPLC column, and it can be easily applied to other substances.
( Yongseok Kim ),( Hophil Min ),( Changmin Sung ),( Ju-hyung Park ),( Junghyun Son ),( Kang Mi Lee ),( Ho Jun Kim ),( Jaeick Lee ),( Oh-seung Kwon ),( Ki Hun Kim ) 한국질량분석학회 2016 Mass spectrometry letters Vol.7 No.4
Glycerol was identified and isolated from endogenous interferences during analysis of human urine using high-resolution mass spectrometry (HRMS) for doping control. Urinary sample preparation was simple; the samples were diluted with an organic solvent and then analyzed using a liquid chromatography-mass spectrometry (“dilute and shoot” method). Although the interfering ion peaks were observed at the similar retention time of glycerol, the inference could be identified by isolation with HRMS and further investigation. Thus, creatinine was identified as the endogenous interference for glycerol analysis and it also caused ion suppression resulting in the decrease of glycerol signal. This study reports the first identification and efficient isolation of endogenous interferences in human urine for “dilute and shoot” method. The information about ion suppression could be novel to prevent overestimation or a false result for antidoping analysis.
Kim, Yongseok,Jeong, Dawon,Min, Hophil,Sung, Changmin,Park, Ju-hyung,Son, Junghyun,Lee, Kang Mi,Kim, Ho Jun,Lee, Jaeick,Kwon, Oh-Seung,Kim, Ki Hun Korean Society for Mass Spectrometry 2017 Mass spectrometry letters Vol.2 No.4
Meldonium is a drug for treating ischemia by expanding the arteries but it can also enhance the performance of sports players. The World Anti-Doping Agency (WADA) has included it in the list of prohibited substances since 2016. Meldonium is one of the challenging substances for anti-doping testing because it is difficult to recover by general liquid-liquid or solid phase extraction due to its permanent charge and high polarity. Therefore, high-performance liquid chromatography (HPLC) is currently used by injecting a diluted urine sample (known as the "dilute-and-shoot" strategy). There is no loss of target compounds in the extraction/cleanup procedure but its high matrix effect could interfere in their separation or detection from the endogenous urinary compounds. We report a single method using high-resolution mass spectrometry that can be used for both screening and confirmation, which follows the "dilute-and-shoot" strategy. In this method, the endogenous compounds' interfering peaks in the mass spectrum are separated at a high resolution of FWHM 140,000, and the results are suitable for substance detection following the WADA guidelines. The interferences in the obtained mass spectrum of the urine matrix are identified as acetylcholine, lysine, and glutamine by further analysis and database searching. Validation of the method is performed in routine anti-doping testing, and the limit of detection is 50 ng/mL. This method uses simple sample preparation and a general reverse phase HPLC column, and it can be easily applied to other substances.
Kim, Yongseok,Min, Hophil,Sung, Changmin,Park, Ju-hyung,Son, Junghyun,Lee, Kang Mi,Kim, Ho Jun,Lee, Jaeick,Kwon, Oh-Seung,Kim, Ki Hun Korean Society for Mass Spectrometry 2016 Mass spectrometry letters Vol.7 No.4
Glycerol was identified and isolated from endogenous interferences during analysis of human urine using high-resolution mass spectrometry (HRMS) for doping control. Urinary sample preparation was simple; the samples were diluted with an organic solvent and then analyzed using a liquid chromatography-mass spectrometry ("dilute and shoot" method). Although the interfering ion peaks were observed at the similar retention time of glycerol, the inference could be identified by isolation with HRMS and further investigation. Thus, creatinine was identified as the endogenous interference for glycerol analysis and it also caused ion suppression resulting in the decrease of glycerol signal. This study reports the first identification and efficient isolation of endogenous interferences in human urine for "dilute and shoot" method. The information about ion suppression could be novel to prevent overestimation or a false result for antidoping analysis.
코에서 선천성 섬유상피폴립이 피부뿔로 발현한 환자 증례보고
권용석(Yongseok Kwon),전동근(Dongkeun Jun),이명철(Myungchul Lee),최현곤(Hyungon Choi),신동혁(Donghyeok Shin),김지남(Jeenam Kim) 대한두경부종양학회 2020 대한두경부 종양학회지 Vol.36 No.2
Cutaneous horn is the clinical entity, which is circumscribed, conical, markedly hyperkeratotic lesion in which the height of the keratotic mass amounts to at least half of its largest diameter. It may be associated with many different pathological lesions. It is a relatively rare and a kind of epidermal tumor that generally appears as a conical projection. Here, we report rare case of congenital cutaneous horn. A 39-month-old female Korean patient presented at our clinic with a mass at the tip of her nose present since birth. Under general anesthesia, cutaneous horn of nasal tip was completely excised without any complications. The operation site was small enough to perform a primary closure, without any nasal deformity. Histopathologically, it was reported as a fibroepithelial polyps. After operation, there is no evidence of recurrence at 16 months of follow-up.