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소대화,전용우,이영매,임병제,Korobova, Natalya 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
YBCO superconducting thick films were perpared on Ag wire by electrophoresis in acetone and ethanol with chemically modified suspension. The addition of organic compounds, such a PEG into suspension solution for improving critical current density was investigated. Surfac state, deposition conditions, pore distribution and cracks were investigated by using SEM photographs. Controlling preparation conditions were studied for reducing these defects. As a results, in acetone slolution, the surface crack of samples was decreased with increasing PEG. To develop optimum microstructures for samples processes affect the microstructure and hence the properties of ceramic superconductors.
소대화,박정철,이영매,조용준,Korobova, Natalya 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
For the research of the effects on suspension solution with YBcO and BSCCO for elcectrophoretic deposition to prepare superconducting thick film wire, the preheating technique for the superconducting powders in vaccum system was used with various solvent solutions for electrophoresis such as acetone, toluen and buthanol was investigated. As a result, it was useful to remove the influence of remaining and adsorbed solvent solution which was existed between and on the particle surfaces when the specimens of superconducting wire by electrophoresis were treated in vacuum of 10-3 Torr and temperature around 200℃ in bell-jar system. Of the prepared superconducting wire samples, the critical current density, Jc was measured by 4-point prove method in liquid N₂, and at the value of 10³to 10⁴A/㎠, respectively, for the YBCO and BSCCO superconducting wires.
소대화,전용우,이영매,김태완,Korobova, Natalya 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
In this study, by using the electrophoresis, preparation of YBCO superconducting wire deposited on metal Ag base wire was studied with its properties. YBCO powder could be prepared by solid state reactions with calcining and sintering processes. Superconducting wire prepared on metal Ag wire used as cathode of deposition base could be also fabricated in the YBCO/acetone-dispersed solution to obtain several tens of ㎛ thick films. In the process of film deposition, a catalyst I₂added into the suspension solution was very useful for preparing thick film of YBCO, and BaF₂ of additive material was also necessary for preparing crack-free wire of YBCO superconductor. As a result, YBCO superconducting wire added 2~3wt.% of BaF₂with catalyst, I₂had better deposition condition for uniform and dense YBCO wires, and critical current density, Jc was calculated at the value of 1,458A/㎠ (more than 10³A/㎠, 77K, 0[T]) of 30㎛ thick sample by 4-point prove method.
Du, Yong,Yan, Shu-Mei,Gu, Wan-Yi,He, Fan,Huang, Li-Yun,Li, Mei,Yuan, Yan,Chen, Ren-Hui,Zhong, Qian,Li, Man-Zhi,Li, Yong,Zeng, Mu-Sheng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
FADS1 (fatty acid desaturase 1) plays a crucial role in fatty acid metabolism, and it was recently reported to be involved in tumorigenesis. However, the role of FADS1 expression in esophageal squamous cell carcinoma (ESCC) remains unknown. In the current study, we investigated the expression and clinical pathologic and prognostic significance of FADS1 in ESCC. Immunohistochemical analyses revealed that 58.2% (146/251) of the ESCC tissues had low levels of FADS1 expression, whereas 41.8% (105/251) exhibited high levels of FADS1 expression. In positive cases, FADS1 expression was detected in the cytoplasm of cells. Correlation analyses demonstrated that FADS1 expression was significantly correlated with tumor location (p=0.025) but not with age, gender, histological grade, tumor status, nodal status or TNM staging. Furthermore, patients with tumors expressing high levels of FADS1had a longer disease-free survival time (p<0.001) and overall survival time (p <0.001). Univariate and multivariate analyses revealed that, along with nodal status, FADS1 expression was an independent and significant predictive factor (p<0.001). In conclusion, our study suggested that FADS1 might be a valuable biomarker and potential therapeutic target for ESCC.
Zhu, Jia-Ying,Li, Yuyao,Cao, Dong-Mei,Yang, Hongjuan,Oh, Eunkyoo,Bi, Yang,Zhu, Shengwei,Wang, Zhi-Yong Elsevier 2017 Molecular cell Vol.66 No.5
<P><B>Summary</B></P> <P>The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In <I>Arabidopsis</I>, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated brassinosteroid (BR) signaling. Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 while blocking its substrate access. Loss-of-function mutations of KIB1 and its homologs abolished BR-induced BIN2 degradation and caused severe BR-insensitive phenotypes. KIB1 directly interacted with BIN2 in a BR-dependent manner and promoted BIN2 ubiquitination in vitro. Expression of an F-box-truncated KIB1 caused BIN2 accumulation but dephosphorylation of its substrate BZR1 and activation of BR responses because KIB1 blocked BIN2 binding to BZR1. Our study demonstrates that KIB1 plays an essential role in BR signaling by inhibiting BIN2 through dual mechanisms of blocking substrate access and promoting degradation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> KIB1 is an essential positive regulator in brassinosteroid signaling </LI> <LI> KIB1 mediates BR-induced ubiquitination and degradation of GSK3 kinase BIN2 </LI> <LI> KIB1 binding to BIN2 prevents BIN2-substrate interaction and promotes BIN2 degradation </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Intermedins A and B; New Metabolites from Schisandra propinqua var. intermedia
Li, Hong-Mei,Lei, Chun,Luo, Yong-Ming,Li, Xiao-Nian,Li, Xiao-Lei,Pu, Jian-Xin,Zhou, San-Yun,Li, Rong-Tao,Sun, Han-Dong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
A new dibenzocyclooctadiene lignan, intermedin A (1), and a new natural bisabolane sesquiterpenoid, intermedin B (2), were isolated from the aerial parts of Schisandra propinqua var. intermedia. Their structures were elucidated on the basis of extensive spectroscopical analysis.
Research on the Computer Music Production Technology System under the Digital Background
Yong Mei Li,Jingqiu Liu,Yi Wen Zhang,Chen Chen,Xuan Guan 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.11
Computer music, as an important product of the information and digital age, belongs to the systems engineering combining the musical discipline with computer information control technology science. Through the applied research on digitalized acoustical signals, characteristic analysis of computer music, computer MIDI production technology, digital audio technology and computer music production software, this paper builds up a set of computer music production technology system based on a digital, informational and modernized background, and proves by experiments that this system makes the computer music production technology represent effects of simple and convenient usage, high-degree simulation and efficient extraction.
Yong-Li Zhou,Xue-Wen Xie,Mei-Rong Xu,Jin-Ping Zang,Ling-Hua Zhu,Jian-Long Xu,Zhi-Kang Li 한국식물학회 2012 Journal of Plant Biology Vol.55 No.2
The genetic components responsible for the qualitative and quantitative resistance of rice to three Chinese races (C2, C4, and C5) of Xanthomonas oryzae pv. oryzae (Xoo)were investigated at the seedling and adult stages in two successive years in set of Lemont/Teqing cross introgression lines (ILs) in a Teqing background, to create a complete linkage map using 160 well-distributed SSR markers. Teqing was resistant to C2 and C4, but moderately susceptible to C5,whereas Lemont was susceptible to all three races. Highly significant correlations were detected among the resistance to different races at different developmental stages. A major gene (Xa4), 14 main-effect QTLs (M-QTLs), and 18 epistatic QTLs were identified in the two developmental stages over 2 years,and were largely responsible for the segregation of resistance in the ILs. In 2007, the Lemont alleles at all loci in the seedling stage, except QBbr10 to C4, increased lesion length (LL) or decreased resistance. The Teqing allele at the Xa4 locus acted as a resistance gene against C2 and C4, but acted as a M-QTL when its resistance was overcome by the virulent race C5. MQTLs showed a degree of race specificity and had a cumulative effect on resistance. Most M-QTLs (94%) consistently expressed resistance to the same race at the seedling and adult stages, indicating that a high degree of genetic overlap exists between Xoo resistance at both developmental stages in rice. Among the digenic interactions, most co-introgressed Lemont alleles at the two epistatic loci lead to significantly smaller LL with all three races, compared to other types of interacting alleles at both development stages. The results indicate that a high level of resistance may be achieved by the cumulative effect of multiple M-QTLs, including the residual effects of “defeated” major resistance genes and the epistatic effects of co-introgression from diverse susceptible varieties.
Wang, Mei,Gu, Jun,Wang, Hai-Xing,Wu, Mei-Hong,Li, Yong-Mei,Wang, Ya-Jie Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Purpose: To investigate the efficacy and toxicity of a combination of gemcitabine with nedaplatin (GN) or cisplatin (GC) for patients with unresectable or recurrent esophagus squamous cell carcinoma. Methods: Gemcitabine was administered at 1 g/m2 intravenously on days 1 and 8; and nedaplatin or cisplatin were administered at 80 mg/m2 intravenously on day 1. We analyzed the response rate, overall survival time, progression-free survival time, and toxicity in 21 patients treated with GN and 27 patients treated with GC. Results: In patients treated with gemcitabine plus nedaplatin, the ORR was 47.6%, the median progression-free survival time was 4.1 months, and the median survival time was 9.3 months. In patients treated with gemcitabine plus cisplatin, the ORR was 48.2%, the median progression-free survival time was 3.9 months, and the median survival time was 9.1 months, respectively. There were no statistically significant differences in ORR, PFS and OS between the two groups. In both, the most commonly observed toxicities were thrombocytopenia and fatigue. Nausea and vomiting was more frequent in the GC group than in the GN group. Conclusion: Gemcitabine based chemotherapy was effective and tolerable for patients with unresectable or recurrent esophagus squamous cell carcinoma refractory to first line chemotherapy.