Role of span length in the adaptation of implant-supported cobalt chromium frameworks fabricated by three techniques

Zhou Ying,Li Yong,Ma Xiao,Huang Yiqing,Wang Jiawei 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.2

PURPOSE. This study evaluated the effect of span length on the adaptation of implant-supported cobalt chromium frameworks fabricated by three techniques. MATERIALS AND METHODS. Models with two solid abutment analogs at different inter-abutment distances were digitized using a laboratory scanner. Frameworks of two-, three-, and four-unit fixed prostheses were designed by a computer. Six dots with a diameter of 0.2 mm were preset on the surface of each framework. A total of 54 implant-supported cobalt chromium frameworks were fabricated by milling, selective laser melting (SLM), and cast techniques. The frameworks were scanned and exported as Stereolithography files. Distances between two dots in X, Y, and Z coordinates were measured in both the designed and fabricated frameworks. Marginal gaps between the framework and the abutments were also evaluated by impression replica method. RESULTS. In terms of distance measurement, significant differences were found between three- and four-unit frameworks, as well as between two- and four-unit frameworks prepared by milling technique (P<.05). Significant differences were also noted between two- and three-unit frameworks, as well as between two- and four-unit frameworks prepared by cast technique (P<.05). The milling technique presented smaller differences than the SLM technique, and the SLM technique showed smaller differences than the cast technique at any unit prostheses (P<.05). Evaluation with the impression replica method indicated significant differences among the span lengths for any fabrication method (P<.05), as well as among the fabrication methods at any unit prostheses (P<.05). CONCLUSION. The adaptation of implant-supported cobalt chromium frameworks was affected by the span length and fabrication method.

A resource preserved MAC protocol for QoS provided UWB ad hoc networks

Jiachen Zhou,Yiqing Huang,Takeshi Ikenaga 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7

This paper proposes a resource preserved medium access control (MAC) protocol which provides Quality of Service (QoS) support for multimedia applications in ultra-wideband (UWB) ad hoc network. The proposed protocol accounts for the UWB unique characteristics while considering the QoS requirements. The evaluation results in throughputs, end to end delay, power consumption and power utilization show that, the proposed algorithms achieve a balance work between the throughputs and power consumption.

Incorporating CsPbBr3 Nanocrystals into Porous AlO(OH) Matrices to Improve their Stability in Backlit Displays

Jiangcong Zhou,Yiqing Lai,Na Lin,Xiaotian Huang,Yu Chen,Yao Yao,Bo Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.15 No.01

Currently, the poor stability of inorganic perovskite CsPbX3 (X = Cl, Br, I) nanocrystals restricts their practical application in optoelectronic devices. Therefore, improving the stability of this material remains an urgent task for most researchers. In this study, incorporation of CsPbBr3 nanocrystals into porous AlO(OH) matrices through simple in situ synthesis was demonstrated to be an efficient approach for improving the nanocrystal stability. X-ray diffraction (XRD) revealed that the as-obtained product was composed of cubic CsPbBr3 nanocrystals and orthorhombic AlO(OH) compounds. In addition, transmission electron microscopy (TEM) revealed that the CsPbBr3 nanocrystals were successfully encapsulated by AlO(OH) matrices. The Brunauer–Emmett–Teller (BET) specific surface area was 234.96 m2 g -1 for AlO(OH) and 60.08 m2 g -1 for the CsPbBr3@AlO(OH) composites. The decrease in surface area could be attributed to the filling of the AlO(OH) pores by the CsPbBr3 nanocrystals. Further, the as-prepared composites showed red-shifted emission at 522 nm and a larger full width at half-maximum (FWHM) as 26 nm, compared with those of the CsPbBr3 nanocrystals with the emission at 517 nm and FWHM as 17 nm. More importantly, the emission intensity preserved 67% of the original value after a storage time of 120 h, but bare CsPbBr3 nanocrystals rapidly degraded within only 1 h in the polar ethanol solution. Finally, a light-emitting diode (LED) device was fabricated by coating the CsPbBr3@AlO(OH) composites and red commercial K2SiF6:Mn4+ phosphors on the surface of a blue InGaN chip, covering 96% of National Television Standards Committee. The results indicate that the obtained composites could be promising luminescent materials for backlit displays.

Energy Efficient Feedback Design for Coordinated Multi-Point Transmission in Downlink

Yi Wang,Yanjun Hu,Yiqing Zhou 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.6

Coordinated multi-point (CoMP) has been raised to increase the average cell throughput and the cell-edge user throughput. However, the energy consumption of mobile stations (MSs) is a key problem restricting the wide application of CoMP systems. Considering the energy consumption of feeding back channel state information (CSI) by MSs and the influence of CSI accuracy on the throughput of system, it is proposed to measure the relationship between feedback energy consumption and throughput with energy efficiency feedback utility (EEFU) function which can adapt to different application scenes by adjusting utilization coefficient. The feedback utilization of two precoders in CoMP systems is analyzed respectively, including the optimization allocation of feedback bits with utility function. The complete EEFU optimized expression and the optimizing flow path satisfying the actual application demands of CoMP systems are then derived. The simulation results illustrate the practicability and necessity of the EEFU function and verify the performance of EEFU with different precoders.

Small Molecule-Based Strategy Promotes Nucleus Pulposus Specific Differentiation of Adipose-Derived Mesenchymal Stem Cells

Hua, Jianming,Shen, Ning,Wang, Jingkai,Tao, Yiqing,Li, Fangcai,Chen, Qixin,Zhou, Xiaopeng Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.9

Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising for regenerating degenerated intervertebral discs (IVDs), but the low efficiency of nucleus pulposus (NP)-specific differentiation limits their clinical applications. The Sonic hedgehog (Shh) signaling pathway is important in NP-specific differentiation of ADSCs, and Smoothened Agonist (SAG) is a highly specific and effective agonist of Shh signaling. In this study, we proposed a new differentiation strategy with the use of the small molecule SAG. The NP-specific differentiation and extracellular matrix (ECM) synthesis of ADSCs were measured in vitro, and the regenerative effects of SAG pretreated ADSCs in degenerated IVDs were verified in vivo. The results showed that the combination of SAG and transforming growth factor-${\beta}3$ ($TGF-{\beta}3$) is able to increase the ECM synthesis of ADSCs. In addition, the gene and protein expression levels of NP-specific markers were increased by treatment with SAG and $TGF-{\beta}3$. Furthermore, SAG pretreated ADSCs can also improve the disc height, water content, ECM content, and structure of degenerated IVDs in vivo. Our new differentiation scheme has high efficiency in inducing NP-specific differentiation of ADSCs and is promising for stem cell-based treatment of degenerated IVDs.

Small Molecule-Based Strategy Promotes Nucleus Pulposus Specific Differentiation of Adipose-Derived Mesenchymal Stem Cells

Jianming Hua,Ning Shen,Jingkai Wang,Yiqing Tao,Fangcai Li,Qixin Chen,Xiaopeng Zhou 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.9

Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising for regenerating degenerated intervertebral discs (IVDs), but the low efficiency of nucleus pulposus (NP)-specific differentiation limits their clinical applications. The Sonic hedgehog (Shh) signaling pathway is important in NP-specific differentiation of ADSCs, and Smoothened Agonist (SAG) is a highly specific and effective agonist of Shh signaling. In this study, we proposed a new differentiation strategy with the use of the small molecule SAG. The NP-specific differentiation and extracellular matrix (ECM) synthesis of ADSCs were measured in vitro, and the regenerative effects of SAG pretreated ADSCs in degenerated IVDs were verified in vivo. The results showed that the combination of SAG and transforming growth factor-β3 (TGF-β3) is able to increase the ECM synthesis of ADSCs. In addition, the gene and protein expression levels of NP-specific markers were increased by treatment with SAG and TGF-β3. Furthermore, SAG pretreated ADSCs can also improve the disc height, water content, ECM content, and structure of degenerated IVDs in vivo. Our new differentiation scheme has high efficiency in inducing NP-specific differentiation of ADSCs and is promising for stem cell-based treatment of degenerated IVDs.

Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential

Xu Xuemeng,Peng Qiu,Jiang Xianjie,Tan Shiming,Yang Yiqing,Yang Wenjuan,Han Yaqian,Chen Yuyu,Oyang Linda,Lin Jinguan,Xia Longzheng,Peng Mingjing,Wu Nayiyuan,Tang Yanyan,Li Jinyun,Liao Qianjin,Zhou Yuju 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during tumorigenesis and cancer progression, indicating regulated metabolic plasticity. Metabolic changes are often closely related to epigenetic changes, such as alterations in the expression or activity of epigenetically modified enzymes, which may exert a direct or an indirect influence on cellular metabolism. Therefore, exploring the mechanisms underlying epigenetic modifications regulating the reprogramming of tumor cell metabolism is important for further understanding tumor pathogenesis. Here, we mainly focus on the latest studies on epigenetic modifications related to cancer cell metabolism regulations, including changes in glucose, lipid and amino acid metabolism in the cancer context, and then emphasize the mechanisms related to tumor cell epigenetic modifications. Specifically, we discuss the role played by DNA methylation, chromatin remodeling, noncoding RNAs and histone lactylation in tumor growth and progression. Finally, we summarize the prospects of potential cancer therapeutic strategies based on metabolic reprogramming and epigenetic changes in tumor cells.