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RISS 인기검색어
- 검색키워드
- 저자 : Yiguang Chen (검색결과 4 건)
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Chen, Yixi,Cao, Jianping,Zhao, Qihui,Luo, Haiyong,Wang, Yiguang,Dai, Wenjian The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the progression of atherosclerosis. Here we report atheroprotective effects of silencing MR-1 in a model of Ang II-accelerated atherosclerosis, characterized by suppression focal adhesion kinase (FAK) and nuclear factor kappaB ($NF-{\kappa}B$) signaling pathway, and atherosclerotic lesion macrophage content. In this model, administration of the siRNA-MR-1 substantially attenuated Ang II-accelerated atherosclerosis with stabilization of atherosclerotic plaques and inhibited FAK, Akt, mammalian target of rapamycin (mTOR) and NF-kB activation, which was associated with suppression of inflammatory factor and atherogenic gene expression in the artery. In vitro studies demonstrated similar changes in Ang II-treated vascular smooth muscle cells (VSMCs) and macrophages: siRNA-MR-1 inhibited the expression levels of proinflammatory factor. These studies uncover crucial proinflammatory mechanisms of Ang II and highlight actions of silencing MR-1 to inhibit Ang II signaling, which is atheroprotective.
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Yixi Chen,Jianping Cao,Qihui Zhao,Haiyong Luo,Yiguang Wang,Wenjian Dai 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However,little information is available on the relationship between MR-1 expression and the progression of atherosclerosis. Here we report atheroprotective effects of silencing MR-1 in a model of Ang II-accelerated atherosclerosis, characterized by suppression focal adhesion kinase (FAK) and nuclear factor kappaB (NF-κB) signaling pathway,and atherosclerotic lesion macrophage content. In this model, administration of the siRNA-MR-1 substantially attenuated Ang II-accelerated atherosclerosis with stabilization of atherosclerotic plaques and inhibited FAK, Akt, mammalian target of rapamycin (mTOR) and NF-kB activation, which was associated with suppression of inflammatory factor and atherogenic gene expression in the artery. In vitro studies demonstrated similar changes in Ang II-treated vascular smooth muscle cells (VSMCs) and macrophages: siRNA-MR-1 inhibited the expression levels of proinflammatory factor. These studies uncover crucial proinflammatory mechanisms of Ang II and highlight actions of silencing MR-1 to inhibit Ang II signaling, which is atheroprotective.
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Sohn, Chae Hoon,Chen, Zheng,Ju, Yiguang Elsevier 2015 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.86 No.-
<P><B>Abstract</B></P> <P>This work investigates numerically the effects of spectral dependent radiation on laminar flame speed determination using spherically propagating CH<SUB>4</SUB>/air and H<SUB>2</SUB>/air flames with CO/CO<SUB>2</SUB>/H<SUB>2</SUB>O dilutions at elevated pressures. Three different models, adiabatic, optically thin radiation, and fitted statistically narrow band correlated <I>k</I> (FSNB-CK) models, are employed. The effects of radiation-induced negative burned gas velocity, increased density ratio, and chamber confinement induced flow compression are investigated. It is found that compared to the FSNB-CK model, the adiabatic flame model over-predicts the flame speed by 7% and the optically thin model makes more significant under-prediction. Moreover, this discrepancy increases with pressure. The results also show that a large negative velocity in the burned gas is induced by radiative heat loss and magnified further by the flow compression in a small combustion chamber. The radiation-induced negative burned gas velocity causes an under-estimation of flame speed. Moreover, radiation also increases the density ratio between the burned and the unburned gases. The use of the density ratio of adiabatic flame also causes under-prediction of flame speed. Two radiation corrections taking into account of the negative burned gas velocity and the increased density ratio are recommended for flame speed determination using propagating spherical flame for radiative mixtures. The corrections proposed in this study reduce the uncertainty of flame speed due to radiation.</P>
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Yunfeng Xiao,Lei Zeng,Zhenkun Cui,Siqian Jin,Yiguang Chen 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.1
The seismic performance of steel beam to concrete-encased composite column with unsymmetrical steel section joints is investigated and reported within this paper. Experimental and analytical evaluation were conducted on a total of 8 specimens with T-shaped and L-shaped steel section under lateral cyclic loading and axial compression. The test parameters included concrete strength, stirrup ratio and axial compression ratio. The response of the specimens was presented in terms of their hysterisis loop behavior, stress distribution, joint shear strength, and performance degradation. The experiment indicated good structural behavior and good seismic performance. In addition, a three-dimensional nonlinear finite-element analysis simulating was conducted to simulate their seismic behaviors. The finite-element analysis incorporated both bond-slip relationship and crack interface interaction between steel and concrete. The results were also compared with the test data, and the analytical prediction of joint shear strength was satisfactory for both joints with T-shaped and L-shaped steel section columns. The steel beam to concrete-encased composite column with unsymmetrical steel section joints can develop stable hysteretic response and large energy absorption capacity by providing enough stirrups and decreased spacing of transverse ties in column.
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