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Micromesh carbon nanosheet electrodes fabricated by phase-separation of immiscible polymer blends
Son, Su-Young,Yeo, Jun-Seok,Jung, Gun Young,Lee, Sungho,Joh, Han-Ik THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.64 No.-
<P><B>Abstract</B></P> <P>We adopt micromesh structure in carbon nanosheets (M-CNS) fabricated by phase-separation of immiscible polyacrylonitrile/poly(methyl methacrylate) blend precursors to improve their properties as a transparent conductive electrode. The facile approach without any time-consuming patterning processes can improve trade-off between sheet resistance and optical transmittance of conventional CNS. The M-CNS exhibits improved sheet resistance of ∼50% without compromising optical transmittance, leading to a high power conversion efficiency of ∼2.07% for M-CNS electrode-based organic photovoltaics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We developed carbon nanosheets with micromesh structure (M-CNSs) via phase-separation of immiscible polymer blends. </LI> <LI> M-CNSs exhibited improved sheet resistance of ∼50% without compromising optical transmittance. </LI> <LI> M-CNS electrode-based organic photovoltaics provided better performance than traditional CNS-based devices. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jun Hyeon Cho,Jong Hee Lee,Ji Yun Lee,Young Bo Son,Soo Kwon Park,Sang Yeol Kim,Choon Woo Lee,Un Sang Yeo,Dong Soo Park,You Cheon Song,Min Hee Nam 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Geneally, rice seeds regardless indica or japonica are showing low germination ratio or completely lost germination ability together with lost of good eating quality under high temperature and humidity conditions. Thus, this study was designed to evaluate a longevity for conservation of good eating quality during long term storage in rice. For the longevity evaluation, germination ability was studied after 5 days of high temperature and humidity stress (50℃/RH 95%). Dharial, originated from Bangladesh and showing weedy type with red pericarp, was selected as a good donor for longevity genes. A mutant was developed from Dharial through EMS mutagenesis and two populations of Dharial/4*Ilmibyeo and Dharial/4*Gopumbyeo were also developed for genetic study. In the 2-DE analysis followed by MALDI-TOF MS with wild and mutant lines, several candidate genes were identified. In the longevity test of two populations, a few lines showing good germination ability after high temperature and humidity stress were selected and subjected to confirm the relationships between longevity and conservation of good eating quality under long term storage.
Treatment of Axillary Osmidrosis Using a Subcutaneous Pulsed Nd-YAG Laser
Kim, Dae-Jin,Kim, Jun-Hyung,Yeo, Hyeon-Jung,Kwon, Hyuk-Jun,Son, Dae-Gu,Han, Ki-Hwan Korean Society of Plastic and Reconstructive Surge 2012 Archives of Plastic Surgery Vol.39 No.2
Background : Axillary osmidrosis is characterized by an unpleasant odor, profuse sweating, and in some instances, staining of clothes that may socially and psychologically impair affected individuals. Various types of surgical procedures have been developed for the treatment of axillary osmidrosis. This study was undertaken to evaluate the effectiveness of subcutaneous pulsed neodymium: yttrium-aluminum-garnet (Nd-YAG) laser treatment for the treatment of axillary osmidrosis. Methods : Twenty-nine patients with axillary osmidrosis were included in this study. Patients were categorized according to the results of an axillary malodor grading system, and a subcutaneous pulsed Nd-YAG laser was applied to all patients. The treatment area for the appropriate distribution of laser energy was determined using the iodine starch test (Minor's test) against a grid pattern composed of $2{\times}2cm$ squares. The endpoint of exposure was 300 to 500 J for each grid, depending on the preoperative evaluation results. The results were evaluated by measurement of axillary malodor both pre- and postoperatively using the grading system and iodine starch test. Results : The average follow-up period was 12.8 months. Nineteen patients had a fair-to-good result and ten patients had poor results. The postoperative Minor's test demonstrated that there were remarkable improvements for patients with mild to moderate symptoms. Complications including superficial second degree burns (n=3) were treated in a conservative manner. A deep second degree burn (n=1) was treated by a surgical procedure. Conclusions : Subcutaneous pulsed Nd-YAG laser has many advantages and is an effective noninvasive treatment for mild to moderate axillary osmidrosis.
Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
Yu Ji Eun,Yeo In Jun,Han Sang-Bae,Yun Jaesuk,Yun Jaesuk,Yong Yoon Ji,Lim Young-soo,Kim Tae Hun,Son Dong Ju,Hong Jin Tae 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosclerosis. Several studies have shown that CHI3L1 can be considered as a marker of disease diagnosis, prognosis, disease activity, and severity. In addition, the proinflammatory action of CHI3L1 may be mediated via responses to various proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 may contribute to a vast array of inflammatory diseases. However, its pathophysiological and pharmacological roles in the development of inflammatory diseases remain unclear. In this article, we review recent findings regarding the roles of CHI3L1 in the development of inflammatory diseases and suggest therapeutic approaches that target CHI3L1.
Amyloidogenic, neuroinfl ammatory and memory dysfunction effects of HIV-1 gp120
Young-Jung Lee,In Jun Yeo,Dong Young Choi,Jaesuk Yun,Dong Ju Son,Sang-Bae Han,홍진태 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
Human immunodeficiency virus 1 (HIV-1)infection can cause several HIV-associated neurocognitivedisorders a variety of neurological impairments characterizedby the loss of cortical and subcortical neuronsand decreased cognitive and motor function. HIV-1 gp120,the major envelope glycoprotein on viral particles, actsas a binding protein for viral entry and is known to be anagent of neuronal cell death. To determine the mechanismof HIV-1 gp120-induced memory dysfunction, we performedmouse intracerebroventricular (i.c.v.) infusion withHIV-1 gp120 protein (300 ng per mouse) and investigatedmemory impairment and amyloidogenesis. Infusion of theHIV-1 gp120 protein induced memory dysfunction, whichwas evaluated using passive avoidance and water maze tests. Infusion of HIV-1 gp120 induced neuroinfl ammation, suchas the release of iNOS and COX-2 and the activation ofastrocytes and microglia and increased the mRNA and proteinlevels of IL-6, ICAM-1, M-CSF, TIM, and IL-2. In particular,we found that the infusion of HIV-1 gp120 inducedthe accumulation of amyloid plaques and signs of elevated amyloidogenesis, such as increased expression of amyloidprecursor protein and BACE1 and increased β-secretaseactivity. Therefore, these studies suggest that HIV-1 gp120may induce memory impairment through Aβ accumulationand neuroinfl ammation.
Exosomes: A new delivery system for tumor antigens in cancer immunotherapy
Cho, Jung-Ah,Yeo, Dong-jun,Son, Hye-Youn,Kim, Hyun-Wha,Jung, Dae-Sun,Ko, Jae-Kyun,Koh, Jason Soonju,Kim, Yong-Nyun,Kim, Chul-Woo Alan R. Liss, Inc 2005 International journal of cancer Vol.114 No.4
<P>Exosomes are small membrane vesicles that are released into the extracellular environment during fusion of multivesicular bodies with plasma membrane. Exosomes are secreted by various cell types including hematopoietic cells, normal epithelial cells and even some tumor cells. They are known to carry MHC class I, various costimulatory molecules and some tetraspanins. Recent studies have shown the potential of using native exosomes as immunologic stimulants. Here, we demonstrate a novel means of using exosomes engineered to express a specific tumor antigen to generate an immune response against tumors. We expressed a target tumor antigen, human MUC1 (hMUC1), in 2 MHC type-distinct mouse cell lines, CT26 and TA3HA. Analysis of exosomes purified from these cells revealed that exosomes contained the target MUC1 antigen on their surfaces as well as other well-described exosomal proteins, including Hsc70 and MHC class I molecules. In addition, both autologous and allogenic exosomes were able to stimulate the activation of immune cells and suppress hMUC1-expressing tumor growth in a MUC1-specific and dose-related manner. Therefore, these data suggest that exosomes can be engineered from tumor cell lines to deliver a target immunogen capable of inducing an effective immune response and that they may represent a new cell-free tumor vaccine. © 2004 Wiley-Liss, Inc.</P>