Morphine에 依한 組織 Catecholamine含量의 變動에 미치는 Clonidine의 影響

李哲毅,全普權,申萬鍊 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

It has been well known that noradrenaline neurons appear to be involved in both morphine and clonidine analgesia, and there are many evidences that the effects of the two drugs on brain noradrenaline-turnover are inhibitory. But the functional role of brain noradrenaline in the suppressive effect of clonidine on the development of opioid withdrawal signs has not yet been clarified. The present study was therefore undertaken in order to ascertain whether brain noradrenaline is responsible for clonidine-induced suppression of development of development of opioid withdrawal signs or cross-tolerance to morphine and clonidine, and so, seventeen hours after the last of 12 injections of increasing doses of both morphine and clonidine over 6 days according to the modified Paalzow’s and Weinstock’s and Weinstock’s methods of the development of tolerance to the two drugs of morphine and clonidine on brain and heart catecholamine contents were estimated in male mice. The results obtained were summarized as follows: 1. Morphine (20㎎/㎏ i.p.) slightly increased brain catecholamine content and significantly increased heart catecholamine content. The morphine-induced increase of brain catecholamine content was not altered all along the 7 day treatment of it, but the morphine-induced increase of heart catecholamine content was augmented after the 4 day treatment of it and the augmentation showed a moderate decline after the 7 day treatment. 2. Clonidine (500㎍/㎏ i.p.) significantly increased both brain and heart catecholamine contents. The clonidine-induced increase of brain catecholamine content was not altered all along the 7 day treatment of it, but the clonidine-induced increase of heart catecholamine content was slightly augmented after the 4 day treatment of it and then recovered to the initial level. 3. The combined effect of morphine and clonidine on the both brain and heart catecholamine contents was additive, and the additive combined-effect was not altered all along the 7 day treatment of the two drugs. The above results suggest that the tolerance development of morphine and the clonidineinduced suppression of opioid withdrawal signs may be mediated through other neuronal systems as well as noradrenergic system.

財務比率의 分類및 橫的分布 形態에 관한 實證的 硏究

宋寅萬,睦怡均 成均館大學校 韓國産業硏究所 1988 韓國經濟 Vol.16 No.-

Extended use of Prostate Health Index and percentage of [-2]pro-prostate-specific antigen in Chinese men with prostate specific antigen 10–20 ng/mL and normal digital rectal examination

Peter Ka-Fung Chiu,Jeremy Yuen-Chun Teoh,Wai-Man Lee,Chi-Hang Yee,Eddie Shu-Yin Chan,See-Ming Hou,Chi-Fai Ng 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.5

Purpose: We investigated the extended use of Prostate Health Index (PHI) and percentage of [-2]pro-prostate-specific antigen (%p2PSA) in Chinese men with prostate-specific antigen (PSA) 10–20 ng/mL and normal digital rectal examination (DRE). Materials and Methods: All consecutive Chinese men with PSA 10–20 ng/mL and normal DRE who agreed for transrectal ultrasound (TRUS)-guided 10-core prostate biopsy were recruited. Blood samples were taken immediately before TRUS-guided prostate biopsy. The performances of total PSA (tPSA), %free-to-total PSA (%fPSA), %p2PSA, and PHI were compared using logistic regression, receiver operating characteristic, and decision curve analyses (DCA). Results: From 2008 to 2015, 312 consecutive Chinese men were included. Among them, 53 out of 312 (17.0%) men were diagnosed to have prostate cancer on biopsy. The proportions of men with positive biopsies were 6.7% in PHI<35, 22.8% in PHI 35–55, and 54.5% in PHI>55 (chi-square test, p<0.001). The area under curves (AUC) of the base model including age, tPSA and status of initial/repeated biopsy was 0.64. Adding %p2PSA and PHI to the base model improved the AUC to 0.79 (p<0.001) and 0.78 (p<0.001), respectively, and provided net clinical benefit in DCA. The positive biopsy rates of Gleason 7 or above prostate cancers were 2.2% for PHI<35, 7.9% for PHI 35–55, and 36.4% for PHI>55 (chi-square test, p<0.001). By utilizing the PHI cutoff of 35 to men with PSA 10–20 ng/mL and normal DRE, 57.1% (178 of 312) biopsies could be avoided. Conclusions: Both PHI and %p2PSA performed well in predicting prostate cancer and high grade prostate cancer. The use of PHI and %p2PSA should be extended to Chinese men with PSA 10–20 ng/mL and normal DRE.

Finding a New Solution of 2+1-Dimensional Gravity

Yee,Soo-man,Kwon,Young-hun 순천향대학교 1994 논문집 Vol.17 No.3

본 소고에서는 2+1-차원의 중력이론을 연구한다. 이를 위해 2+1-차원에서 유체형태의 근원을 가지고 있는 경우에 있어서의 새로운 해를 구한다. 이 새로운 형태의 해가 만족하는 상미분 방정식이 유도되어지며 이 새로운 형태의 해에 대한 기하학적 양들이 주어진다.

The Conformal Transformation in the Skyrme Model on S³

Yee,Soo-Man 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.2

우리는 스컴 모델을 S3상에서 구현하였는데 이 모델에 공변변환(Conformal Transformation)을 적용하였다. 이 모델에서의 결과는 수치적인 계산과 매우 유사한 결과를 얻었다.

Should transanal total mesorectal excision be implemented in medium-sized colorectal unit? technical and oncological outcome

Man-fung Ho,Dennis Chung-Kei Ng,Janet Fung-yee Lee,Simon Siu-man Ng 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.3

Purpose: This study was performed to evaluate the outcome of implementation of transanal total mesorectal excision (TaTME) for low rectal cancer in a regional hospital and in comparison to laparoscopic (Lap) TME. Methods: Consecutive patients with low rectal cancer of which the lowest border of the tumour was located beween 1 and 5 cm from the puborectalis who underwent TME at North District Hospital between January 2013 and December 2019 were included. Clinical, operative, and pathologic outcomes were compared between Lap TME and TaTME. The primary end point was complication profile. Results: Thirty-five patients underwent Lap TME and 45 patients underwent TaTME for low rectal cancer. The conversion rate of the TaTME group was significantly lower than that of the Lap TME group (4.4% vs. 20%, P=0.029), but the operating time was longer (259 minutes vs. 219 minutes, P=0.009). The tumour location was significantly lower in the TaTME group, but the distal resection margins were adequate and not different between both groups. The TaTME group had higher incidence rates of prolonged ileus and urinary tract infection, but the other complications were similar between the two groups. The resection margin positivity rates of the TaTME and Lap TME groups were 2.2% and 5.7%, respectively (P=0.670). At a median follow up of 39 months, no abnormal early recurrence was detected. Conclusion: It is technically feasible and oncologically safe to perform TaTME in a medium-volume colorectal unit. Patients with difficult pelvic anatomy can benefit by reducing the risk of conversion and margin positivity rate.

The Order Parameter in the B=2 Skyrme Model on S^3

Yee, Soo-Man 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

우리는 B=2 스컴 모델을 S^3상에서 구현하였는데 이 모델에서의 오더 파라매터를 얻었는데 프로닥터 안짜즈 보다 이를 간단히 구할수있었다.

The Solution of Profile Function in the B=2 Skyrme Model on S^3 with the Pion Mass Term

Yee, Soo-Man 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

우리는 B=2 스컴 모델에 파이온 항이 추가된 모형을 S^3상에서 구현하였는데 이 모델에서의 프로파일 함수의 해를 얻었었다. B=2 모형에서는 이항이 카이랄 대칭성을 깨는 역할을 한다.

Lawyers and Hong Kong’s democracy movement: from electoral politics to civil disobedience

Man Yee Karen Lee 서울대학교행정대학원 2017 Asian Journal of Political Science Vol.25 No.1

Research on Hong Kong lawyers has so far focused on their internal differences and the rise of cause lawyering. Not much has been done on their role in promoting political liberalism. This paper fills a gap by reviewing the history of lawyers’ political activism before and after Hong Kong’s sovereignty shifted from a liberal-colonial to an authoritarian regime in 1997. It argues, first, that Hong Kong’s post-colonial constitutionalized politics and prolonged democratic deficit have given the legal complex—which includes lawyers and also increasingly legal academics—a key role in its pro-democracy movement, and second, critical political junctures have driven activist lawyers to use various means, from electoral politics to civil disobedience, to defend the rule of law and Hong Kong’s tortuous democratization.

The Restoration of Chiral Symmetry from Skyrme Model on S³

Yee, Soo-man 순천향대학교 기초과학연구소 1996 순천향자연과학연구 논문집 Vol.2 No.2

S³에서의 스컴 모형을 사용하여 고밀도 상태의 강입자의 성질을 연구하였다. 이러한 고밀도 환경에서는 쿼크의 응축이 사라지는 영역이 있게 되는데 우리는 이를 카이랄 대칭성의회복이라고 해석하였다.