Radiation dosimetry of 89Zr labeled antibody estimated using the MIRD method and MCNP code

Yazdi Saeideh Izadi,Sadeghi Mahdi,Saeedzadeh Elham,Jalilifar Mostafa 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.4

One important issue in using radiopharmaceuticals as therapeutic and imaging agents is predicting different organ absorbed dose following their injection. The present study aims at extrapolating dosimetry estimates to a female phantom from the animal data of 89Zr radionuclide accumulation using the Sparks-Idogan relationship. The absorbed dose of 89Zr radionuclide in different organs of the human body was calculated based on its distribution data in mice using both MIRD method and the MCNP simulation code. In this study, breasts, liver, heart wall, stomach, kidneys, lungs and spleen were considered as source and target organs. The highest and the lowest absorbed doses were respectively delivered to the liver (4.00E-02 and 3.43E-02 mGy/MBq) and the stomach (1.83E-03 and 1.66E-03 mGy/MBq). Moreover, there was a good agreement between the results obtained from both MIRD and MCNP methods. Therefore, according to the dosimetry results, [89Zr] DFO-CR011-PET/CT seems to be a suitable for diagnostic imaging of the breast anomalies for CDX-011 targeting gpNMB in patients with TNBC in the future.

Liver Dysfunction and Oxidative Stress in Streptozotocin-Induced Diabetic Rats: Protective Role of Artemisia Turanica

Yazdi, Hassan Bgheri,Hojati, Vida,Shiravi, Abdolhossein,Hosseinian, Sara,Vaezi, Gholamhassan,Hadjzadeh, Mousa-Al-Reza KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.2

Objectives: Oxidative stress plays a central role in diabetes-induced complications. In the present study, the protevtive effect of Artemisia turanica (A. turanica) was evaluated against diabetes-induced liver oxidative stress and dysfunction. Methods: Fifty male Wistar rats were randomly divided into five groups: control, diabetic, diabetic + metformin, diabetic + A. turanica extract, and diabetic + A. turanica extract + metformin. Experimental diabetes was induced by a single-dose (55 mg/kg, intraperitoneally (ip)) injection of streptozotocin (STZ). Metformin (300 mg/kg) and A. turanica extract (70 mg/kg) were orally administrated three days after STZ injection for four weeks. The levels of malondialdehyde (MDA), total thiol content and superoxide dismutase (SOD) and catalase activities were measured in the liver tissue. Serum glucose concentration, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were also determined. Results: In the diabetic group, serum glucose concentration, serum AST and ALT activities and liver MDA level were significantly higher while tissue total thiol content as well as catalase and SOD activities were lower, compared to the control group. Serum glucose in diabetic rats treated with metformin + A. turanica extract showed a significant decrease compared with the diabetic group. In all the A. turanica extract and metformin treated groups, serum ALT, tissue MDA level, total thiol content and SOD activity significantly improved compared with the diabetic rats. However, treatment of the diabetic rats only with metformin could not significantly change the activities of catalase and AST compared with the diabetic group. Conclusion: These findings suggested that A. turanica extract had a therapeutic effect on liver dysfuncyion and oxidative stress induced by diabetes, that may be probably due to its antioxidant and antiinflammatory effects.

Stochastic Multiobjective Optimization Model for Urban Drainage Network Rehabilitation

Yazdi, J.,Lee, E. H.,Kim, J. H. American Society of Civil Engineers 2015 Journal of water resources planning and management Vol.141 No.8

Intelligent Pump Operation and River Diversion Systems for Urban Storm Management

Yazdi, J.,Kim, J. H. American Society of Civil Engineers 2015 Journal of hydrologic engineering Vol.20 No.11

Evaluation of Methylobacterium radiotolerance and Sphyngomonas yanoikoaie in Sentinel Lymph Nodes of Breast Cancer Cases

Yazdi, Hamid Reza,Movafagh, Abolfazl,Fallah, Fateme,Shargh, Shohreh Alizadeh,Mansouri, Neda,Pour, Atefeh Heidary,Hashemi, Mehrdad Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

It has been established that different kinds of bacteria agents are involved in various cancers. Although the mechanism of tumorigenesis is not clearly understood, there is evidence for the presence of bacteria within tumors, with at least a progression effect for some bacteria that prepare suitable microenvironments for tumor cell growth. The aim of current study was to evaluate bacterial dysbiosis in sentinel lymph nodes of breast cancer patients. One hundred and twenty three fresh-frozen sentinel lymph nodes and a corresponding number of normal adjacent breast tissue specimens and five normal mastectomy samples were investigated employing RT-PCR. In addition using genus-specific primers were applied. There was a significant differences as presence of Methylobacterium radiotolerance DNA recorded between patients and normal control group (p= 0.0). Based on our research work, further studies into the role of microbes in breast cancer would be of great interest.

Effect of intravenous magnesium on postoperative pain control for major abdominal surgery: a randomized double-blinded study

Yazdi Arash Peivandi,Esmaeeli Mehrdad,Gilani Mehryar Taghavi 대한마취통증의학회 2022 Anesthesia and pain medicine Vol.17 No.3

Background: Magnesium sulfate has been used in different studies as a pain control agent; however, the results are contradictory. This study aimed to evaluate the effect of magnesium sulfate on postoperative pain management during abdominal surgery. Methods: This randomized double-blinded study involved 84 patients candidates for abdominal surgery, who were divided into two groups (42 patients in each group). In the magnesium group, 25 mg/kg magnesium sulfate was infused for 1 h; then, 100 mg/kg/24 h was infused in the intensive care unit. The patients’ pain intensity, which was the primary outcome, was assessed using the numeric rating scale (NRS) every 3 h. If the NRS was > 3, morphine was used and evaluated as a secondary outcome after 24 h. The patients and nurses who assessed the patients were blinded to the drug groups. The results were analyzed using SPSS ver. 19 software, and statistical significance was set at P < 0.05.Results: Age, sex, body mass index (BMI) and surgery duration were similar between the groups. The pain intensity was 4 ± 0.2 in the control and 3.8 ± 0.2 in the magnesium group at first and then 3.98 ± 0.2 in the control and 3.45 ± 0.2 in the magnesium group at the third hour, which were similar in both groups (P = 0.39 and P = 0.17, respectively), but thereafter between 6 and 24 h, the pain severity was significantly lower in the magnesium group (4.4 ± 1.3 in the control and 3.34 ± 1 in the magnesium group at 6th hour and P = 0.001). In addition, morphine intake in the first 24 h in the two groups had a significant difference, with 13.2 ± 5.7 in control group and 8 ± 3.5 in magnesium group (P = 0.001). Hemodynamic state and muscle relaxation were similar in both groups.Conclusions: In this study, intravenous magnesium sulfate after abdominal surgeries for 24 h resolved the pain intensity after six hours and reduced morphine dosage.

Large amplitude forced vibration of functionally graded nano-composite plate with piezoelectric layers resting on nonlinear elastic foundation

Yazdi, Ali A. 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.68 No.2

This paper presents a study of geometric nonlinear forced vibration of carbon nano-tubes (CNTs) reinforcement composite plates on nonlinear elastic foundations. The plate is bonded with piezoelectric layers. The von Karman geometric nonlinearity assumptions with classical plate theory are employed to obtain the governing equations. The Galerkin and homotopy perturbation method (HPM) are utilized to investigate the effect of carbon nano-tubes volume fractions, large amplitude vibrations, elastic foundation parameters, piezoelectric applied voltage on frequency ratio and primary resonance. The results indicate that the carbon nano-tube volume fraction, applied voltage and elastic foundation parameters have significant effect on the hardening response of carbon nanotubes reinforced composite (CNTRC) plates.

A methodology for optimal operation of pumping stations in urban drainage systems

Yazdi, J.,Choi, H.S.,Kim, J.H. Elsevier Publishing Services 2016 JOURNAL OF HYDRO-ENVIRONMENT RESEARCH Vol.11 No.-

Over the past two decades, flood risks have presented a significant challenge for urban areas owing to the increased peak flows resulting from urbanization and climate change. In metropolitan areas, large-scale networks of sewer pipes and pump stations are the main facilities used to mitigate flood damage. During flooding periods, when drainage gates are closed, pumping operations play a major role in efficiently reducing flood damage. To obtain an optimal policy for these operations, a novel robust approach is presented here. In this approach, a long-term operating rule is designed by coupling a mathematical model and a new hybrid harmony search algorithm, while considering the stochastic nature of rainfall events. Application of the proposed method to a real urban drainage system showed a high efficiency in terms of flood mitigation and performance of pumps compared to the current operating rule for the pump station. Compared to the traditional approach, optimal operation decreased peak water levels by an average of 40%, without increasing the number of pump switches. Based on these results, optimizing pumping operations appear to be a practical and highly effective way to reduce flood water levels and urban inundation without making changes to the actual infrastructure of the system.

Comparative study of multi-objective evolutionary algorithms for hydraulic rehabilitation of urban drainage networks

Yazdi, J.,Yoo, D. G.,Kim, J. H. Informa UK (TaylorFrancis) 2017 Urban water journal Vol.14 No.5

<P>Multi-Objective Evolutionary Algorithms (MOEAs) are flexible and powerful tools for solving a wide variety of non-linear and non-convex problems in water resources engineering contexts. In this work, two well-known MOEAs, the Strength Pareto Evolutionary Algorithm (SPEA2) and Non-dominated Sorting Genetic Algorithm (NSGA2), and two additional MOEAs that are extended versions of harmony search (HS) and differential evolution (DE), are linked to the Environmental Protection Agency's Storm Water Management Model (SWMM-EPA), which is a hydraulic model used to determine the best pipe replacements in a set of sewer pipe networks to decrease urban flooding overflows. The performance of the algorithms is compared for several comparative metrics. The results show that the algorithms exhibit different behaviours in solving the hydraulic rehabilitation problem. In particular, the multi-objective version of the HS algorithm provides better optimal solutions and clearly outperforms the other algorithms for this type of nondeterministic polynomial-time hard (NP-hard) problem.</P>

CYP2D6 Genotype and Risk of Recurrence in Tamoxifen Treated Breast Cancer Patients

Yazdi, Mohammad Forat,Rafieian, Shiva,Gholi-Nataj, Mohsen,Sheikhha, Mohammad Hasan,Nazari, Tahereh,Neamatzadeh, Hossein Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: Despite consistent pharmacogenetic effects of CYP2D6 on tamoxifen exposure, there is considerable controversy regarding the validity of CYP2D6 as a predictor of tamoxifen outcome. Understanding the current state of evidence in this area and its limitations is important for the care of patients who require endocrine therapy for breast cancer. Materials and Methods: A total of 101 patients with breast cancer who received tamoxifen therapy for at least 3 years, were genotyped for common alleles of the CYP2D6 gene by nested-PCR and restriction fragment length polymorphism PCR. Patients were classified as extensive or poor metabolizers (PM) based on CYP2D6*4 alleles in 3 different groups according to the menopause, Her2-neu status, and stage 3. Results: The mean age of the patients with the disease recurrence was $50.8{\pm}6.4$ and in non recurrent patients was $48.2{\pm}6.8$. In this study 63.3% (n=64) patients were extensive metabolizers and 36.6% (n=37) were poor metabolizers. Sixty four of the 101 patients (63.3%) were Her2-neu positive. For tamoxifen-treated patients, no statistically significant difference in rate of recurrence observed between CYP2D6 metabolic variants in stage 3 and post-menopausal patients. However, there was a significant association between CYP2D6 genotype and recurrence in tamoxifen-treated Her2-neu positive patients. Compared with other women with breast cancer, those with Her2-neu positive breast cancer and extensive metabolizer alleles had a decreased likelihood of recurrence. Conclusions: This study for the first time demonstrated significant effects of CYP2D6 extensive metabolizer alleles on risk of recurrence in Her2-neu positive breast cancer patients receiving adjuvant tamoxifen therapy. Therefore, CYP2D6 metabolism, as measured by genetic variation, can be a predictor of breast cancer outcome in Her2-neu positive women receiving tamoxifen.