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ENCODE: A Sourcebook of Epigenomes and Chromatin Language
Yavartanoo, Maryam,Choi, Jung Kyoon Korea Genome Organization 2013 Genomics & informatics Vol.11 No.1
Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism. Now we know that this conclusion is an oversimplification. In April 2003, the National Human Genome Research Institute (NHGRI) launched an international research consortium called Encyclopedia of DNA Elements (ENCODE) to uncover non-coding functional elements in the human genome. The result of this project has identified a set of new DNA regulatory elements, based on novel relationships among chromatin accessibility, histone modifications, nucleosome positioning, DNA methylation, transcription, and the occupancy of sequence-specific factors. The project gives us new insights into the organization and regulation of the human genome and epigenome. Here, we sought to summarize particular aspects of the ENCODE project and highlight the features and data that have recently been released. At the end of this review, we have summarized a case study we conducted using the ENCODE epigenome data.
ENCODE: A Sourcebook of Epigenomes and Chromatin Language
Maryam Yavartanoo,최정균 한국유전체학회 2013 Genomics & informatics Vol.11 No.1
Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism. Now we know that this conclusion is an oversimplification. In April 2003, the National Human Genome Research Institute (NHGRI) launched an international research consortium called Encyclopedia of DNA Elements (ENCODE) to uncover non-coding functional elements in the human genome. The result of this project has identified a set of new DNA regulatory elements, based on novel relationships among chromatin accessibility, histone modifications, nucleosome positioning, DNA methylation, transcription, and the occupancy of sequence-specific factors. The project gives us new insights into the organization and regulation of the human genome and epigenome. Here, we sought to summarize particular aspects of the ENCODE project and highlight the features and data that have recently been released. At the end of this review, we have summarized a case study we conducted using the ENCODE epigenome data.
On EVH black hole solution in heterotic string theory
North Holland 2012 Nuclear physics, B Vol.863 No.2
We study the near horizon geometry of charged rotating black holes in toroidal compactifications of heterotic string theory. We analyze the extremal vanishing horizon (EVH) limit for these black hole solutions and we will show that the near horizon geometry develops an AdS<SUB>3</SUB> throat. Furthermore, we will show that the near horizon limit of near EVH black holes has a BTZ factor. We also comment on the CFT dual to this near horizon geometry.
Positronium-like states from supergravity
O Colgain, E.,Yavartanoo, H. North Holland 2009 Nuclear Physics, Section B Vol.822 No.1
We study semi-classical rotating open strings ending on a probe Dp-brane close to a stack of extremal, non-extremal Dp-branes and Dp-branes with B-fields. These states may be interpreted as positronium-like bound states of spinning W-bosons in an SU(N+1)->SU(N)xU(1) theory. In each case, we describe the behaviour of the strings and examine the relation between the energy and the angular momentum of the bound state.