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- 저자 : Yao-sen Huang (검색결과 2 건)
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Hu-zhi Zhang,Peng Luo,Jian Yuan,Yao-sen Huang,Jia-dong Liu 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.4
By presetting various reinforcement diameters in topology optimization with the discrete model finite element analysis, an algorithm of bidirectional evolutionary structural optimization of multi-level reinforcement diameter is presented to obtain the optimal reinforcement topologies which describe the degree of stress of different parts. The results of a comparative study on different reinforcement feasible domain demonstrate that the more angle types of reinforcement are arranged in the initial domain, the higher utilization rate of reinforcement of the optimal topology becomes. According to the nonlinear finite element analysis of some deep beam examples, the ones designed with the optimization results have a certain advantage in ultimate bearing capacity, although their failure modes are greatly affected by the reinforcement feasible domain. Furthermore, the bearing capacity can be improved when constructional reinforcements are added in the subsequent design. However the adding would change the relative magnitude of the bearing capacity between the normal and inclined section, or the relative magnitude between the flexural and shear capacity within the inclined section, which affects the failure modes of components. Meanwhile, the adding would reduce the deformation capacity of the components as well. It is suggested that the inclined reinforcement and the constructional reinforcement should be added properly to ensure a desired ductile failure mode for components.
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Zhuang Bao-Jun,Xu Su-Yun,Dong Liang,Zhang Pei-Hai,Zhuang Bao-Lin,Huang Xiao-Peng,Li Guang-Sen,You Yao-Dong,Chen Di'Ang,Yu Xu-Jun,Chang De-Gui 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.4
The protein encoded by dynein axonemal heavy chain 1 (DNAH1) is a part of dynein, which regulates the function of cilia and sperm flagella. The mutant of DNAH1 causes the deletion of inner dynein arm 3 in the flagellum, leading to multiple morphological abnormalities of the sperm flagella (MMAF) and severe asthenozoospermia. However, instead of asthenozoospermia and MMAF, the result caused by the mutation of DNAH1 remains unknown. Here we report a male infertility patient with severe asthenozoospermia and teratozoospermia. We found two heterozygous mutations in DNAH1 (c.6912C>A and c.7076G>T) and which were reported to be associated with MMAF for the first time. We next collected and analyzed 65 cases of DNAH1 mutation and found that the proportion of short flagella is the largest, while the bent flagella account for the smallest, and the incidence of head deformity is not high in the sperm of these patients. Finally, we also analyzed 31 DNAH1 mutation patients who were treated with intracytoplasmic sperm injection (ICSI) and achieved beneficial outcomes. We hope our research will be helpful in the diagnosis and treatment of male infertility caused by DNAH1 mutation.
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