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( Zhe Shi ),( Liyuan Zhou ),( Yan Zhou ),( Xiaoyan Jia ),( Xiangjun Yu ),( Xiaohong An ),( Yanzhen Han ) 생화학분자생물학회 2022 BMB Reports Vol.55 No.6
Chloride channel-5 (ClC-5), an important branch of the ClC family, is involved in the regulation of the proliferation and cell-fate of a variety of cells, including tumor cells. However, its function in cholangiocarcinoma (CCA) cells remains enigmatic. Here, we discovered that ClC-5 was up-regulated in CCA tissues and CCA cell lines, while ClC-5 silencing inhibited CCA cell proliferation and induced apoptosis. Further mechanism studies revealed that ClC-5 inhibition could inhibit Wnt/β-catenin signaling activity and further activate the mitochondria apoptotic pathway in CCA cells. Furthermore, rescuing Wnt/β-catenin signaling activation eliminated the anti-tumor function of ClC-5 knockdown. Together, our research findings illustrated that ClC-5 inhibition plays an anti-tumor role in CCA cells via inhibiting the activity of the Wnt/β-catenin pathway, which in turn activates the mitochondrial apoptotic pathway. [BMB Reports 2022; 55(6): 299-304]
Chenguang Wang,Youping Yi,Shiquan Huang,Fei Dong,Hailin He,Ke Huang,Yanzhen Jia 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.12
Cryogenic forming, a new technology used to manufacture aluminum alloy thin-walled parts, has attracted much attentionin recent years. This work presents an experimental and theoretical study of 2024-O aluminum alloy sheet forming limit atcryogenic temperatures and provides an effective method for accurate prediction of forming limit curves (FLCs) at cryogenictemperatures. Uniaxial tensile experiments at different temperatures were carried out between 20 °C and − 196 °C to obtainthe constitutive equation of the material at cryogenic temperatures. The Marciniak–Kuczynski (M–K) model was used topredict FLCs at cryogenic and room temperatures. The constitutive equation and yield functions are used in the model. Theeffects of different yield criteria (Mises, Hill-48, Barlat89, Gotoh, and Yld2000-2d) on the prediction results of FLC areanalyzed. These prediction results were verified by the Nakazima test, and it was found that the Yld2000-2d yield criterion isthe most accurate for FLC prediction. Finally, the M–K model is combined with this criterion to predict the FLC at differenttemperatures. It was found that the lower the temperature, the higher the FLC curve and the better the sheet formability, andthe increase is more obvious at extremely low temperatures.