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Data-driven intelligent computational design for products: method, techniques, and applications
Yang Maolin,Jiang Pingyu,Zang Tianshuo,Liu Yuhao 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.4
Data-driven intelligent computational design (DICD) is a research hotspot that emerged under fast-developing artificial intelligence. It emphasizes utilizing deep learning algorithms to extract and represent the design features hidden in historical or fabricated design process data and then learn the combination and mapping patterns of these design features for design solution retrieval, generation, optimization, evaluation, etc. Due to its capability of automatically and efficiently generating design solutions and thus supporting human-in-the-loop intelligent and innovative design activities, DICD has drawn the attention of both academic and industrial fields. However, as an emerging research subject, many unexplored issues still limit the development and application of DICD, such as specific dataset building, engineering design-related feature engineering, systematic methods and techniques for DICD implementation in the entire product design process, etc. In this regard, a systematic and operable road map for DICD implementation from a full-process perspective is established, including a general workflow for DICD project planning, an overall framework for DICD project implementation, the common mechanisms and calculation principles during DICD, key enabling technologies for detailed DICD implementation, and three case scenarios of DICD application. The road map can help academic researchers to locate their specific research directions for the further development of DICD and provide operable guidance for the engineers in their specific DICD applications.
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Cheng Luyi,Yang Tianshuo,Zhang Jun,Gao Feng,Yang Lingyun,Tao Weijing 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.6
Radiopharmaceuticals targeting prostate-specific membrane antigens (PSMA) are essential for the diagnosis, evaluation, and treatment of prostate cancer (PCa), particularly metastatic castration-resistant PCa, for which conventional treatment is ineffective. These molecular probes include [68Ga]PSMA, [18F]PSMA, [Al18F]PSMA, [99mTc]PSMA, and [89Zr]PSMA, which are widely used for diagnosis, and [177Lu]PSMA and [225Ac]PSMA, which are used for treatment. There are also new types of radiopharmaceuticals. Due to the differentiation and heterogeneity of tumor cells, a subtype of PCa with an extremely poor prognosis, referred to as neuroendocrine prostate cancer (NEPC), has emerged, and its diagnosis and treatment present great challenges. To improve the detection rate of NEPC and prolong patient survival, many researchers have investigated the use of relevant radiopharmaceuticals as targeted molecular probes for the detection and treatment of NEPC lesions, including DOTA-TOC and DOTA-TATE for somatostatin receptors, 4A06 for CUB domain-containing protein 1, and FDG. This review focused on the specific molecular targets and various radionuclides that have been developed for PCa in recent years, including those mentioned above and several others, and aimed to provide valuable up-to-date information and research ideas for future studies.
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