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A residual stress analysis program using a Matlab GUI on an autofrettaged compound cylinder
Qiu-Ming Yang,이영신,이은엽,김재훈,Ki-Up Cha,홍석균 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.11
A program for the residual stress analysis of an autofrettaged compound cylinder is designed using a Matlab graphical user interface (GUI) and program design technique. The high-pressure vessels are autofrettaged in order to increase their operating pressure and fatigue life. An autofrettage process causes plastic expansion of the inner section of the cylinder, adding residual compressive stress to the bore after relaxation. Such a compound cylinder is produced via a shrink-fit procedure that incorporates a monobloc tube that has previously undergone autofrettage. This paper presents a simple and visual tool to calculate the residual stress and describe the distribution of residual stress for both the elastic-perfectly plastic model and the strain-hardening model.
Comments on joint terms in gravitational action
Yang, Run-Qiu,Ruan, Shan-Ming Institute of Physics 2017 Classical and quantum gravity Vol.34 No.17
<P>This paper compares three different methods of computing joint terms in the on-shell action of gravity, which are identifying the joint term by the variational principle in the Dirichlet boundary condition, treating the joint term as the limit contribution of a smooth boundary and finding the joint term by local SO(<img ALIGN='MIDDLE' ALT='$1, d-1$ ' SRC='http://ej.iop.org/images/0264-9381/34/17/175017/cqgaa8053ieqn001.gif'/>) transformation. In general metric gravitational theory, we show that the differences between these joint terms are variational invariants under a fixed boundary condition. We also give an explicit condition to judge the existence of a joint term determined by the variational principle and apply it to general relativity as an example.</P>
MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.
Qiu Yang,Yuan Yonggang,Luo Ping 한국유전학회 2022 Genes & Genomics Vol.44 No.2
Background: MiRNAs belong to non-coding RNAs that are involved in cancer development. Acting as a mediator, they could regulate the expression level of numerous gens. However, the expression and function of miR-1299 in gastric cancer (GC) are not clear. Objective: To explore the role of miR-1299 in the process of GC. Methods: We detected the levels of miR-1299 in clinical samples of GC and investigated the role of miR-1299 in the regulation of the GC cells proliferation, apoptosis and metastasis. Luciferase reporter assay was employed to verify the target of miR-1299. Additionally, the proliferation, apoptosis and metastasis of AGS and SGC7901 cells were analyzed after the overexpression of miR-1299. Results: Our study showed the expression of miR-1299 was decreased in GC tissues and cell lines. It indicated that the cell proliferation, migration and invasion was inhibited, while the cell apoptosis was promoted by the over-expressed miR-1299. Also, we found that miR-1299 could directly target the 3'-untranslated region (3'UTR) of ARF6 genes. In addition, rescue assay demonstrated that miR-1299 overexpression promoted the cell apoptosis and inhibited cell growth, which could be attenuated by the overexpression of ARF6. Conclusions: These findings indicate that miR-1299 regulates cell progression in GC by targeting ARF6 genes, and suggest that miR-1299 may be a tumor suppressor in the GC progression.