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- 저자 : Yan-Biao Fu (검색결과 2 건)
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Yan-Bin Zhang,Fu-Quan Chen,Yu-Jian Lin,Hao-Biao Chen 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
Inverted T-type retaining walls are commonly used in subgrade or slope support engineering, which inevitably satisfies a narrow backfill. Using the classical earth pressure calculation method in a narrow-backfill case causes an inevitable error. The current narrow-backfill earth pressure theory does not apply to inverted T-type retaining walls. In this study, the failure mechanism in a narrow backfill when the inverted T-type retaining wall rotates about the heel is investigated using adaptive finite element analysis method. Numerical analysis reveals multiple sliding surfaces. A theoretical model for calculating earth pressure using difference and limit equilibrium methods is proposed. The proposed model is suitable for more complex conditions, including narrow backfill, irregular ground, and non-uniform overload, than previous models. Parameter analysis reveals that the cross-sectional area of the plastic zone and active earth pressure have a positive correlation. Further, the interface friction influences the decrease in active earth pressure. Fitting formulas for assessing the cases of long and short heel and the critical size of backfill width are presented to facilitate practitioners to evaluate the backfill.
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Ascorbic Acid Alleviates Pancreatic Damage Induced by Dibutyltin Dichloride (DBTC) in Rats
Xin-Liang Lu,Yan-Hua Song,Yan-Biao Fu,Jian-Min Si,Ke-Da Qian 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.6
Purpose: Because previous studies have reported depleted antioxidant capacity in patients with chronic pancreatitis (CP), prevention of free radical production has gained importance in antifibrotic treatment strategies for CP. The aim of this study was to investigate the effects of ascorbic acid on oxidative capacity and pancreatic damage in experimental CP. Materials and Methods: CP was induced in male Sprague-Dawley rats by infusion of dibutyltin dichloride (DBTC) into the tail vein. Ascorbic acid was given intraperitoneally at a daily dose of 10mg/kg body weight. The treatment groups were as follows: group 1, DBTC plus intraperitoneal physiologic saline; group 2, DBTC plus intraperitoneal ascorbic acid; group 3, solvent plus intraperitoneal physiologic saline; group 4, no operation plus intraperitoneal physiologic saline. Each group contained 15 animals. Treatment was started after CP was established. After 4 weeks of treatment, serum hyaluronic acid and laminin levels were determined by radioimmunoassay, pancreatic tissue oxidative stress was analyzed, and the degree of pancreatic damage was determined. Results: Ascorbic acid treatment markedly increased superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) concentrations in pancreatic tissue (p<0.01 for both). Significant serum hyaluronic acid and laminin reductions were observed in group 2 as compared with group 1 (p<0.05). However, the serum hyaluronic acid and laminin levels remained elevated when compared with those of groups 3 and 4 (p<0.05). Histopathologic scores were also lower in animals with CP that underwent ascorbic acid-treatment (p<0.05). Conclusion: Ascorbic acid treatment alleviated the degree of oxidative stress and pancreatic damage in rat CP. Antioxidant treatment might be considered a potential option to improve the pathologic process in CP.
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