http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Masayuki Yamasaki,Tetsuro Ogawa,Li Wang,Takuya Katsube,Yukikazu Yamasaki,Xufeng Sun,Kuninori Shiwaku 한국영양학회 2013 Nutrition Research and Practice Vol.7 No.4
The anti-obesity effects of a hot water extract from wasabi (Wasabia japonica Matsum.) leaves (WLE), without its specific pungent constituents, such as allyl-isothiocyanate, were investigated in high fat-diet induced mice. C57J/BL mice were fed a high-fat diet (control group) or a high-fat diet supplemented with 5% WLE (WLE group). Physical parameters and blood profiles were determined. Gene expression associated with lipid metabolism in liver and white adipose tissue were analyzed. After 120 days of feeding, significantly lower body weight gain, liver weight and epididymal white adipose tissue weight was observed in the WLE group compared to the control group. In liver gene expression within the WLE group, PPARα was significantly enhanced and SREBP-1c was significantly suppressed. Subsequent downstream genes controlled by these regulators were significantly suppressed. In epididymal white adipose tissue of the WLE group, expression of leptin, PPARγ, and C/EBPα were significantly suppressed and adiponectin was significantly enhanced. Acox, related to fatty acid oxidization in adipocytes, was also enhanced. Our results demonstrate that the WLE dietary supplement induces mild suppression of obesity in a high-fat diet induced mice, possibly due to suppression of lipid accumulation in liver and white adipose tissue.
Vacuum degassing behavior of Zr-, Ni- and Cu-based metallic glass powders
Yamasaki, Michiaki,Iwamoto, Kotaro,Tamagawa, Hirokazu,Kawamura, Yoshihito,Lee, Jin-Kyu,Kim, Hwi-Jun,Bae, Jung-Chan Elsevier 2007 Materials science & engineering. properties, micro Vol.449 No.-
<P><B>Abstract</B></P><P>The vacuum degassing behavior of Zr<SUB>55</SUB>Al<SUB>10</SUB>Ni<SUB>5</SUB>Cu<SUB>30</SUB>, Ni<SUB>59</SUB>Zr<SUB>15</SUB>Ti<SUB>13</SUB>Si<SUB>3</SUB>Sn<SUB>2</SUB>Nb<SUB>7</SUB>Al<SUB>1</SUB>, and Cu<SUB>54</SUB>Ni<SUB>6</SUB>Zr<SUB>22</SUB>Ti<SUB>18</SUB> (numbers indicate at.%) metallic glass powders has been investigated and compared with that of Al alloy powder. It was found that the alloy composition influenced the gas desorption behavior with heating <I>in vacuo</I>. Zr<SUB>55</SUB>Al<SUB>10</SUB>Ni<SUB>5</SUB>Cu<SUB>30</SUB> and Ni<SUB>59</SUB>Zr<SUB>15</SUB>Ti<SUB>13</SUB>Si<SUB>3</SUB>Sn<SUB>2</SUB>Nb<SUB>7</SUB>Al<SUB>1</SUB> metallic glass powders exhibited little H<SUB>2</SUB> gas desorption from powder surfaces during vacuum degassing. Because Zr in the Zr-based and Ni-based amorphous alloy powders produced a native zirconium oxide layer, the surface of the Zr<SUB>55</SUB>Al<SUB>10</SUB>Ni<SUB>5</SUB>Cu<SUB>30</SUB> and Ni<SUB>59</SUB>Zr<SUB>15</SUB>Ti<SUB>13</SUB>Si<SUB>3</SUB>Sn<SUB>2</SUB>Nb<SUB>7</SUB>Al<SUB>1</SUB> amorphous alloys had no influence on adsorbed H<SUB>2</SUB>O. Cu<SUB>54</SUB>Ni<SUB>6</SUB>Zr<SUB>22</SUB>Ti<SUB>18</SUB> metallic glass powder was the most affected by atmospheric H<SUB>2</SUB>O among the metallic glass powders examined in this study. The adsorbed H<SUB>2</SUB>O and Cu metal may react with each other with the formation of Cu<SUB>2</SUB>O and liberation of H<SUB>2</SUB> during vacuum degassing. In order to obtain sound P/M final products with Cu-based P/M alloys, oxygen-free copper powders should be used in well-controlled atmospheres with low H<SUB>2</SUB>O partial pressures.</P>
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’
Yamasaki, Satoshi,Yagishita, Naoko,Sasaki, Takeshi,Nakazawa, Minako,Kato, Yukihiro,Yamadera, Tadayuki,Bae, Eunkyung,Toriyama, Sayumi,Ikeda, Rie,Zhang, Lei,Fujitani, Kazuko,Yoo, Eunkyung,Tsuchimochi, K Wiley (John WileySons) 2007 The EMBO journal Vol.26 No.1
<P>Synoviolin, also called HRD1, is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum -associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and pathological processes, including embryogenesis and the pathogenesis of arthropathy. However, little is known about the molecular mechanisms of Synoviolin in these actions. To clarify these issues, we analyzed the profile of protein expression in synoviolin-null cells. Here, we report that Synoviolin targets tumor suppressor gene p53 for ubiquitination. Synoviolin sequestrated and metabolized p53 in the cytoplasm and negatively regulated its cellular level and biological functions, including transcription, cell cycle regulation and apoptosis. Furthermore, these p53 regulatory functions of Synoviolin were irrelevant to other E3 ubiquitin ligases for p53, such as MDM2, Pirh2 and Cop1, which form autoregulatory feedback loops. Our results provide novel insights into p53 signaling mediated by Synoviolin.</P>
Fodder Supply in Cold Season in Gobi Nomadic Area, Mongolia
Yamasaki, S.,Ishida, J. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.2
Fodder supply condition was studied at 41 nomadic families in Gobi, Southern Semi-Desert area in Mongolia, from Dec. 1994 to Apr. 1995 to determine problems in cold, feed deficient season for establishment of sustainable livestock production system. The conditions of two family groups: those located in sparse vegetation (FG1), and those in comparably dense (FG2), were also compared. Commercial concentrate feed (concentrate), hay and Zoodoi were prepared for supplementation. Zoodoi was hand-made feed made mainly of Allium mongolicum and Allium polyrrhizum. Allium mongolicum tended to be used at FG1 frequently, and Allium polyrrhizum at FG2 depend on differences of micro vegetation. 44%, 90% and 39% of families prepared 165.6 kg of concentrate, 301.6 kg of hay and 6.8 kg of Zoodoi per sheep and goat (small livestock) on the average, respectively. The ratio of families that used concentrate at FG1 was smaller than those at FG2, though there were no significant differences on the amount. More hay was fed at FG1 than at FG2, and Zoodoi tended to be fed more in the FG1 group. Recipients were mostly restricted to young, female and sick small livestock that use the feeds effectively. More families gave concentrate and hay to the young than to the females and sick. They also gave more Zoodoi to young and sick animals than to females in this area. In the FG1 group, no differences were found between recipients on the concentrate supply. More families supplied hay to young animals than to sick ones, and Zoodoi was fed more to sick animals than to young and females. On the other hand, those in the FG2 found, more families fed fodders to young than to female and sick regardless of the kinds of feeds. The amount of fodder supplementation in the studied area was restricted, but accurate techniques of nomads to adapt the situation were clarified.
Rapidly Enlarging Pediatric Cortical Ependymoma
Yamasaki, Kouji,Yokogami, Kiyotaka,Yamashita, Shinji,Takeshima, Hideo The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.6
We report a 10-year-old boy with supratentorial cortical ependymoma that rapidly grew in the course of 3 years. He suffered generalized seizures when he was 5 years old; MRI showed a small cortical lesion in the right postcentral gyrus. MRI performed 2 years later revealed no changes. For the next 3 years he was free of seizures. However, at the age of 10 he again suffered generalized seizures and MRI disclosed a large parietal tumor. It was resected totally and he remains free of neurological deficits. The histopathological diagnosis was ependymoma. Pediatric supratentorial cortical ependymomas are extremely rare. We recommend including cortical ependymoma as a differential diagnosis in pediatric patients with cortical mass lesions presenting with seizures and careful follow-up even in the absence of symptoms because these tumors may progress.
Automatic Control for Chase Aircraft
Yamasaki, Takeshi,Enomoto, Keisuke,Tanaka, Daiki,Tanaka, Daiki,Baba, Yoriaki The Korean Society for Aeronautical and Space Scie 2006 International Journal of Aeronautical and Space Sc Vol.7 No.2
Many kinds of unmanned aerial vehicles (UAVs) have been developed for a few decades and some of them are now in operational use. Although each UAV as well as a piloted aircraft might have restrictions to execute some tasks simultaneously or to carry some payloads, one with an automatic chase aircraft might have the potential of multi-capabilities to conduct a variety of missions or to carry more storages. This paper introduces a chase UAV control system to enhance a leader (reference) aircraft capability which has storage restriction. The automatic chase guidance and control system will be introduced with the pure pursuit guidance law combined with relative velocity error corrections, and a dynamic inversion technique in order to generate the guidance forces.
Yamasaki, Masayuki,Mutombo, Paulin Beya wa Bitadi,Iwamoto, Mamiko,Nogi, Akiko,Hashimoto, Michio,Nabika, Toru,Shiwaku, Kuninori The Korean Nutrition Society 2015 Nutrition Research and Practice Vol.9 No.4
BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program. SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: $57{\pm}8years$) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification. RESULTS: Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, $126{\pm}68mg/dl$; TC, $134{\pm}74mg/dl$; and CC, $172{\pm}101mg/dl$. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: $-21.9{\pm}61.0mg/dl$, $-20.9{\pm}51.0mg/dl$, and $-42.6{\pm}78.5mg/dl$, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels. CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.