뇌의부분 손상으로 인한 정동행동의 변화에 관한 연구

이순철,T. Yamamoto.S.Ueki 충남대학교 약학대학 의약품개발연구소 1988 藥學論文集 Vol.4 No.-

Nucleus accumbens septi (NAB), one of mesolimbic system, which anatomically related the limbic system. We an attempted to elucidated emotional changes following bilateral NAB lesions in rats. Caudal, rostral and both areas of NAB were lesioned each in separated animal groups. Furthermore, aggressive behavior induced by NAB rats was investigated in comparison with those induced by olfactory bulbectomized rats and raphe nucleus-lesioned rats. 1) At postoperative day 2, locomotor activity were increased in r-NAB rats but not in c-NAB rats. 2) All rats exhibited hyperirritability and muricide including mouse-eating behavior after NAB lesions. 3) Muricide of NAB rats was significantly supressed by L-DOPA, L-5-HTP and antidepressants, muricide of raphe rats was also significantly inhibited by L-DOPA and L-5-HTP, while that in OB rats was not suppressed. These results suggested that the NAB plays an important role in locomotor activity and aggression. The characteristics of aggressive behavior induced by NAB rats resemble to that of raphe-rats.

Short-term Redistribution of Methylmercury by Sulfur-Containing Compounds

Yamamoto, Ryoji,Sumino, Kimiaki,Nakamae, Katsutoshi,Lee, Won Chang 한국수의공중보건학회 1997 예방수의학회지 Vol.21 No.1

Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.

Yamamoto, Yukio,Lee, Dongwon,Kim, Yoonhee,Lee, Bokyoung,Seo, Changwoo,Kawasaki, Hiroshi,Kuroda, Shinya,Tanaka-Yamamoto, Keiko The Society 2012 The Journal of neuroscience Vol.32 No.41

<P>It was demonstrated previously that a positive feedback loop, including protein kinase C (PKC) and mitogen-activated protein kinase (MAPK), is required for the gradual expression of cerebellar long-term depression (LTD). PKC and MAPK are mutually activated in this loop. MAPK-dependent PKC activation is likely to be mediated by phospholipase A2. On the other hand, it is not clear how PKC activates MAPK. Therefore, the entire picture of this loop was not fully understood. We here test the hypothesis that this loop is completed by the PKC substrate, Raf kinase inhibitory protein (RKIP). To test this hypothesis, we used a mutant form of RKIP that is not phosphorylated by PKC and thus constitutively inhibits Raf-1 and MEK, upstream kinases of MAPK. When this RKIP mutant was introduced into Purkinje cells of mouse cerebellar slices through patch-clamp electrodes, LTD was blocked, while wild-type (WT) RKIP had no effect on LTD. Physiological epistasis experiments demonstrated that RKIP works downstream of PKC and upstream of MAPK during LTD induction. Furthermore, biochemical analyses demonstrated that endogenous RKIP dissociates from Raf-1 and MEK during LTD induction in a PKC-dependent manner, suggesting that RKIP binding-dependent inhibition of Raf-1 and MEK is removed upon LTD induction. We therefore conclude that PKC-dependent regulation of RKIP leads to MAPK activation, with RKIP completing the positive feedback loop that is required for LTD.</P>

Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People

Yasunori Yamamoto,Shinya Furukawa,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Katsuhiko Kohara,Yuka Saeki,Yoichi Hiasa 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2

Background/AimsEvidence regarding the association between body mass index (BMI) and functional dyspepsia (FD) in the Asian population is limited. Further, no study has evaluated this issue in young people in Asian and Western populations. Thus, we aim to investigate this issue among young Japanese people. MethodsThe study subjects comprised of 8923 Japanese university students. BMI was divided into 4 categories (quartiles) on the basis of the study subjects’ distribution (lowest, low, moderate, and high [reference]). The definition of lean, normal, overweight, and obese was BMI < 18.5 kg/m2, 18.5 ≤ BMI < 25 kg/m2 (reference), 25 kg/m2 ≤ BMI < 30 kg/m2, and 30 kg/m2 ≤ BMI, respectively. The definition of FD was based on the Rome III criteria. ResultsThe prevalence of FD was 1.9% in this cohort. The lowest BMI was independently associated with FD after adjustment (adjusted odds ratio [OR], 2.88; 95% confidence interval [CI], 1.46-3.67); P for trend = 0.001). The lowest BMI was independently associated with FD in women but not in men (OR, 2.94; 95% CI, 1.59-5.77; P for trend = 0.001). Leanness was independently associated with FD in total and in women but not in men (total: adjusted OR, 2.01; 95% CI, 1.40-2.86) and women (OR, 2.19; 95% CI, 1.35-3.45). However, interaction analysis showed no significant difference for sex. ConclusionsAmong young Japanese people, BMI may be independently inversely associated with FD. Leanness may be an independent associated factor for FD in the young Japanese women.

타쿠로 야마모토 아키텍츠

타쿠로 야마모토(Takuro Yamamoto) 현대건축사 2016 월간 CONCEPT Vol.- No.205

Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population

Yasunori Yamamoto,Shinya Furukawa,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Teruki Miyake,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Katsuhiko Kohara,Syuichi Saheki,Yuka Saeki,Yoichi Hiasa 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3

Background/AimsFunctional dyspepsia (FD) may be a common digestive disease worldwide and reduces the quality of life of patients. However, only a few studies have investigated the association between eating behavior and FD. The purpose of this cross-sectional study is to examine the association between eating behavior and prevalence of FD in a young Japanese cohort. MethodsIn this study, we enrolled 8923 Japanese university students. FD is diagnosed based on the Rome III criteria. Eating habits and frequency of meals were investigated using a self-administered questionnaire. ResultsThe FD subjects had a younger mean age, a lower body mass index, and a lower proportion of men compared to the non-FD subjects. An independent positive association between skipping breakfast and/or lunch and FD was found (adjusted ORs were 1.60 [95% CI, 1.10-2.32] for breakfast and 2.52 [95% CI, 1.04-5.18] for lunch). Skipping dinner, extra meals (snacks) or midnight snacks was not associated with FD. The prevalence of FD in subjects eating 1, 2, and 3 meals per day was 4.8%, 2.2%, and 1.7%, respectively. The frequency of meals was independently inversely associated with prevalence of FD (adjusted ORs were 1 per day: 2.72 [95% CI, 1.19-5.42], and 2 per day: 1.69 [95% CI, 1.16-2.43], P for trend = 0.001). ConclusionsIn the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD.

Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

( Sayuri Yamamoto ),( Yurika Kawamura ),( Kazuhiro Yamamoto ),( Yoshiharu Yamaguchi ),( Yasuhiro Tamura ),( Shinya Izawa ),( Hiroaki Nakagawa ),( Yoshinori Wakita ),( Yasutaka Hijikata ),( Masahide Eb 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4

Background/Aims Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population. Methods This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors. Results The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group (P < 0.001). Sleep disturbance (P < 0.05), sleep quality, and duration, use of hypnotic medication, and daytime dysfunction of PSQI (all P < 0.001) significantly correlated with poor sleep. In the poor sleep group, QOL was significantly worse and anxiety and depression levels were significantly higher (all P < 0.001) compared with the good sleep group. Anemia and smoking (both P < 0.05), recent body weight increases, and poor eating habits (all P < 0.001) were significantly higher in the poor sleep group. Male sex, onset associated with change in frequency of stools, sensation of incomplete evacuation for at least 25% of defecations, and manual maneuvers to facilitate at least 25% of defecations correlated with poor sleep. Conclusions Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy. (J Neurogastroenterol Motil 2021;27:602-611)

A New Resistor Series For Chip/Network Applications

Yamamoto, Y.,Hayakawa, K.,Matsuno, H.,Sato, T.,Smith, J.,Tojo, M. 한국마이크로전자및패키징학회 1994 Seminar on Hybrid Microelectronics and Multichip P Vol.1 No.1

A new series of resistor compositions has been developed for chip applications. The new series, DuPont 00X0 $quot;INVAROX$quot; has been designed to give well rounded performance on chip resistors of all existing sixes including low TCR effects on small resistors. Because of their low process sensitivity, the 00X0 resistors can also be advantageously used in resistor network applications. To ensure good overall performance, we devised some screening tests that allowed us to easily visualize and understand the effects of composition and processing on resistor performance. The thorough screening of experimental compositions was a key in ensuring that no member of the series has severely limiting flaws. In this paper, we will discuss the development concepts for the new series, our screening tests for experimental compositions, and aspects of performance from a large and growing database.

Program for Calculating the Extreme Value Statistics on the Spreadsheets Software(EVAN-II)

Yamamoto, Masahiro,Shibata, Toshio 한국부식방식학회 2002 Corrosion Science and Technology Vol.31 No.3

The extreme value statistics is widely used for predicting the lives of the various structures and the industrial plants in JAPAN. The program named EVAN, calculating the extreme value statistics, had been developed and sold by JSCE from 1989. However, a long time has passed through the development and it did not match a recent computer generation. And it was restricted only in Japanese language. So, a new program (EVAN-Ⅱ) was developed. Since the program was arranged for a corrosion engineer to calculate extreme value statistics easily, generally used spreadsheet software Excel™ was chosen for the developing platform. Gumbel distribution and GEV (Generalized Extreme Value) distribution are prepared for the extreme value analysis. Both MVLUE (Minimum Variance Linear Unbiased Estimator) method and MLH (Maximum Likelihood) method are applied to calculate the parameters for Gumbel distribution. The prediction of the extreme value of the total population can be carried out using return period. GEV distribution is so-called generalized these three extreme value distribution, such as Gumbel, Weibull and Frechet distribution. The shape parameter (k) of GEV distribution determines a type of distribution among them. If k is nearly equal to zero, GEV distribution is equivalent to Gumbel distribution. Thus, a test of this hypothesis indicates the fitness criterion for Gumbel distribution.

Quality Control of Photosystem II during Photoinhibition

Yamamoto, Yasusi Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2

The reaction center Dl protein of photosystem II is the target of photodamage by excess illumination. The Dl protein is damaged by reactive oxygen species generated by photochemical reactions and then degraded by specific proteolytic enzymes. We found that the Dl protein also cross-links with the surrounding polypeptides, such as D2 and CP43 in isolated thylakoids or photosystem II-enriched membranes from spinach under the illumination with strong visible light. The cross-linking was observed in spinach leaf discs as well when they were illuminated at higher temperature (40°C). It was also shown that the cross-linked products are digested efficiently by a protease(s) in the stroma. Thus the cross-linking/digestion processes of the Dl protein seem to comprise a new pathway in the turnover of the photodamaged Dl protein. It should be noted, however, that the cross-linked products of the Dl protein and CP43 induced by endogenous cationic radicals in the donor-side photoinhibition are resistant to proteolytic digestion. Accumulation of these cross-linked products in the thylakoids may lead to the decay of the function of chloroplasts and finally to the death of plant cells. Thus, we suggest that the quality control of photosystem II, especially removal of the cross-linked products of the Dl protein, is crucial for the survival of chloroplasts under the light stress.