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ALGORITHMS FOR SYSTEMS OFNONLINEAR VARIATIONAL INEQUALITIES
Yeol Je Cho,Ya-ping Fang,Nan-jing Huang,Ho Jin Hwang 대한수학회 2004 대한수학회지 Vol.41 No.3
In this paper, we introduce and study a new system of nonlinear variational inequalities. The existence and uniqueness of solution for this problem are proved and an iterative algorithm for approximating the solution of system of nonlinear variational inequalities is constructed.
이광식(Kwang-Sik Lee),방아위(Ya-Wei Fang),김영훈(Yeong-Hun Kim),윤대희(Dae-Hee Yoon),이창호(Chang-Ho Lee) 한국조명·전기설비학회 2008 조명·전기설비학회논문지 Vol.22 No.12
본 연구는 실내공기와 상수의 수질개선을 위하여 소형 평판형 오존발생기(plate-type ozonizer: PTO)를 개발하여 그 특성을 규명한 논문이다. 평판전극의 크기, 개수 및 배치에 따라 다양한 형태의 오존발생기가 고안되었다. 각 형태의 오존발생기의 방전 면적은 60[cm²]로 동일하며 방전전력은 최대 30[W]이다. 주요 연구 대상은 방전전력 오존생성농도 특성, 방전전력-오존생성수율 특성, 유량-오존생성능도 특성 및 유량-오존생성수율 특성이다. 오존생성특성은 PTOL-P가 가장 우수하게 나타났으며, 나머지 3종류의 오존발생기 (PTO<SUB>P-P</SUB>, PTO<SUB>C-P</SUB>, PTO<SUB>T-P</SUB>)에서는 유사한 결과를 얻을 수 있었다. It is the paper that this study develops the small plate-type ozonizer(PTO) for improvements of indoor air and water, and investigated the characteristics. Electric discharge area of ozonizer of each form is same to 60[cm²], and discharge power is the maximum 30[W]. Ozonizer of various forms was devised according to size, numbers and arrangement. The main study object is discharge power-ozone concentration characteristics, discharge power-ozone yield characteristics, amount of gas flow-ozone concentration characteristics and amount of gas flow-ozone yield characteristics. PTOL-P appeared so as to be most excellentm and ozone generation characteristics were able to get the similar results at three kinds of remaining ozonizer (PTO<SUB>P-P</SUB>, PTO<SUB>C-P</SUB>, PTO<SUB>T-P</SUB>).
Zhang, Yan-Li,Li, Qing,Yang, Xiao-Mei,Fang, Fang,Li, Jun,Wang, Ya-Hui,Yang, Qin,Zhu, Lei,Nie, Hui-Zhen,Zhang, Xue-Li,Feng, Ming-Xuan,Jiang, Shu-Heng,Tian, Guang-Ang,Hu, Li-Peng,Lee, Ho-Young,Lee, Su-J American Association for Cancer Research 2018 Cancer research Vol.78 No.9
<P>Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P>Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and the immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes and initiating immune responses. Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression. Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis. SPON2-α4β1 integrin signaling activated RhoA and Rac1, increased F-actin reorganization, and promoted M1-like macrophage recruitment. F-Actin accumulation also activated the Hippo pathway by suppressing LATS1 phosphorylation, promoting YAP nuclear translocation, and initiating downstream gene expression. However, SPON2-α5β1 integrin signaling inactivated RhoA and prevented F-actin assembly, thereby inhibiting HCC cell migration; the Hippo pathway was not noticeably involved in SPON2-mediated HCC cell migration. In HCC patients, SPON2 levels correlated positively with prognosis. Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.</P><P><B>Significance:</B> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P><B>Graphical Abstract:</B> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg. <I>Cancer Res; 78(9); 2305–17. ©2018 AACR</I>.</P><P><B>Graphical Abstract</B></P><P> [Figure]</P>
Xie, Shaozhen,Lee, Yi-Fen,Kim, Eungseok,Chen, Lu-Min,Ni, Jing,Fang, Lei-Ya,Liu, Su,Lin, Shin-Jen,Abe, Jun-Ichi,Berk, Bradford,Ho, Feng-Ming,Chang, Chawnshang National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.32
<P>Testicular orphan nuclear receptor 4 (TR4) is an orphan member of the nuclear receptor superfamily with diverse physiological functions. Using TR4 knockout (TR4(-/-)) mice to study its function in cardiovascular diseases, we found reduced cluster of differentiation (CD)36 expression with reduced foam cell formation in TR4(-/-) mice. Mechanistic dissection suggests that TR4 induces CD36 protein and mRNA expression via a transcriptional regulation. Interestingly, we found this TR4-mediated CD36 transactivation can be further enhanced by polyunsaturated fatty acids (PUFAs), such as omega-3 and -6 fatty acids, and their metabolites such as 15-hydroxyeico-satetraonic acid (15-HETE) and 13-hydroxy octa-deca dieonic acid (13-HODE) and thiazolidinedione (TZD)-rosiglitazone. Both electrophoretic mobility shift assays (EMSA) and chromatin immunoprecipitation (ChIP) assays demonstrate that TR4 binds to the TR4 response element located on the CD36 5'-promoter region for the induction of CD36 expression. Stably transfected TR4-siRNA or functional TR4 cDNA in the RAW264.7 macrophage cells resulted in either decreased or increased CD36 expression with decreased or increased foam cell formation. Restoring functional CD36 cDNA in the TR4 knockdown macrophage cells reversed the decreased foam cell formation. Together, these results reveal an important signaling pathway controlling CD36-mediated foam cell formation/cardiovascular diseases, and findings that TR4 transactivation can be activated via its ligands/activators, such as PUFA metabolites and TZD, may provide a platform to screen new drug(s) to battle the metabolism syndrome, diabetes, and cardiovascular diseases.</P>
SF?와 제조공기(I-Air)의 압력별 절연파괴특성 비교
이창욱(Chang-Wook Lee),김영수(Young-Su Kim),方亞偉(Ya-Wei Fang),이창훈(Chang-Hun Lee),김도석(Do-Seok Kim),常超(Chao Chang),최은혁(Eun-Hyuck Choi),임창호(Chang-Ho Lim),이광식(Kwang-Sik Lee) 한국조명·전기설비학회 2006 한국조명·전기설비학회 학술대회논문집 Vol.2006 No.11월
본 연구는 현재 전력설비에 사용되고 있는 SF?가스의 대체 절연가스로 제조공기(Ⅰ-Air)의 절연파괴특성 연구를 위하여 모의 GIS 챔버와 AC 300[㎸] 전원장치로 교류전압을 인가하여 연구를 수행하였다. 침 전극 대 평판전극을 이용하여 SF?가스와 I-Air의 절연내력을 비교하기 위해서 3, 4 및 5[atm]까지 가스의 압력변화를 주었고 각 압력별 전극간거리(d)에 따른 절연파괴전압(V<SUB>B</SUB>)을 연구하였다.