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- 저자 : YOSUKE UCHIDA (검색결과 4 건)
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AYANO KAWAE,YOSUKE UCHIDA 한국펄프·종이공학회 2006 한국펄프종이학회 기타 간행물 Vol.- No.-
The aim of this work was to inhibit the heat- and moisture- induced yellowing of ECF/TCF bleached hard wood kraft pulp (HBKP) retaining hexenuronic acid (HexA). We have already reported that one of the derivatives of HexA, 5-formyl-2-furancarboxylic acid (FFA), causes yellowing of HBKP in acidic paper, and that FFA might polymerize or react with pulp components to form new chromophoric groups (1). In this study, it was shown that the carboxylic base of FFA interacts with that of glucuronic acid or galacturonic acid, resulting in strong yellowing. Therefore, it seems that preventing the reaction of carboxylic bases could be effective in suppressing this yellowing. We have discovered that polycarboxylic acids (for example, citric acid, tartaric acid, etc.) are useful as a yellowing inhibitor.
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Yuki Fujii,Kazuyuki Matsumoto,Hironari Kato,Yosuke Saragai,Saimon Takada,Sho Mizukawa,Shinichiro Muro,Daisuke Uchida,Takeshi Tomoda,Shigeru Horiguchi,Noriyuki Tanaka,Hiroyuki Okada 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.5
Background/Aims: This study aimed to examine the diagnostic ability of endoscopic ultrasonography (EUS) for major vascularinvasion in pancreatic cancer and to evaluate the relationship between EUS findings and pathological distance. Methods: In total, 57 consecutive patients who underwent EUS for pancreatic cancer before surgery were retrospectively reviewed. EUSimage findings were divided into four types according to the relationship between the tumor and major vessel (types 1 and 2: invasion,types 3 and 4: non-invasion). We also compared the EUS findings and pathologically measured distances between the tumors andevaluated vessels. Results: The sensitivity, specificity, and accuracy of EUS diagnosis for vascular invasion were 89%, 92%, and 91%, respectively, in theveins and 83%, 94%, and 93%, respectively, in the arteries. The pathologically evaluated distances of cases with type 2 EUS findings weresignificantly shorter than those of cases with type 3 EUS findings in both the major veins (median [interquartile range], 96 [0–742] µmvs. 2,833 [1,076–5,694] µm, p=0.012) and arteries (623 [0–854] µm vs. 3,097 [1,396–6,000] µm, p=0.0061). All cases with a distance of≥1,000 µm between the tumors and main vessels were correctly diagnosed. Conclusions: Tumors at a distance ≥1,000 µm from the main vessels were correctly diagnosed by EUS.
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( Kazutami Sakamoto ),( Yuji Yamashita ),( Hiroyasu Ohtaka ),( Yosuke Hashimoto ),( Masaki Takemura ),( Yoshikazu Uchida ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Trans-Urocanic acid (t-UCA) is recognized as an end metabolite of filaggrin via histidine which is a part of NMF amino acids in the stratum corneum (SC). As an intrinsic chromophore in SC under UV exposure, t-UCA converts to cis isomer (c-UCA) which initiates UV-induced immunosuppression. There are controversial discussions about c-UCA whether its immunosuppressive function is for the protection of body or rather to trigger carcinogenic reactions. Even though, existence of t-UCA in SC and conversion to c-UCA by UV radiation is real events evolved in Nature for the mammalian skin especially in human. The objective of this study is to investigate the transient isomerization of t-UCA in SC to c-UCA during the course of seasonal solar UV Index change in order to better understand the role of UCA for the skin physiology. Ten volunteers with age 21 to 34 are recruited and UCA isomer ratio was measured twice a week for six weeks (Sep 14th through Oct 19 in 2012). SC samples were tape stripped from the inner upper arm and UCA isomers are analyzed by HPLC. Average cis/trans ratio decreased gradually from c.a. 2.0 to 0.2. Solar UV Index reported for the area of experiment also decreased by the duration of days during the 6 weeks test period and there are good correlation found between isomer ratio and Solar UV Index. As a result, dynamic photo-isomerization of UCA in response to the solar UV radiation was confirmed. This finding would lead us further investigation of the functional roles of UCA in the skin especially for the Filaggrin mutation and Atopic Dermatitis, which is one of the hot topics in skin science.
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Kazuyuki Matsumoto,Hironari Kato,Shigeru Horiguchi,Takeshi Tomoda,Akihiro Matsumi,Yuki Ishihara,Yosuke Saragai,Saimon Takada,Shinichiro Muro,Daisuke Uchida,Hiroyuki Okada 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.5
Background/Aims: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA; EUS-FNA) allows for diagnostic tissue specimens from various regions to be analyzed. However, diagnosing recurrent pancreaticobiliary cancer after surgery is sometimes difficult. We evaluated the efficacy of EUS-FNA in the diagnosis of local recurrence of pancreaticobiliary cancer and analyzed the factors associated with falsenegative results. Methods: Fifty-one consecutive patients who underwent EUS-FNA due to suspected recurrence of pancreaticobiliary cancer after surgery in an academic center were retrospectively analyzed. The criteria for EUS-FNA were a resected margin or remnant pancreas mass, round swollen lymph node (≥10 mm in diameter), and soft-tissue enhancement around a major artery. Patients with suspected liver metastasis or malignant ascites were excluded. Results: Thirty-nine of the 51 patients had pancreatic cancer; the remaining 12 had biliary cancer. The target sites for EUS-FNA were the soft tissue around a major artery (n=22, 43%), the resected margin or remnant pancreas (n=12, 24%), and the lymph nodes (n=17, 33%). The median size of the suspected recurrent lesions was 15 mm (range, 8 to 40 mm). The overall sensitivity, specificity and accuracy of EUS-FNA for the diagnosis of recurrence was 84% (32/38), 100% (13/13), and 88% (45/51), respectively. FNA of the soft tissue around major arteries (odds ratio, 8.23; 95% confidence interval, 1.2 to 166.7; p=0.033) was significantly associated with a falsenegative diagnosis in the multivariate analysis. Conclusions: EUS-FNA is useful for diagnosing recurrent cancer, even after pancreaticobiliary surgery. The diagnoses of recurrence at soft-tissue sites should be interpreted with caution.
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