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- 저자 : Xueyi Guo (검색결과 4 건)
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Yanjie Guo,Weini Wu,Xiya Ma,Mingyan Shi,Xueyi Yang 한국유전학회 2019 Genes & Genomics Vol.41 No.6
Background Corneal epithelial cells (CECs) are required for corneal transparency and visual function, and corneal injuries may cause corneal blindness. Skin epidermal stem cells (SESCs), which share the same origin with CECs and have the potential of multi-directional differentiation are ideal seed cells for tissue engineered corneal construction to treat corneal blindness. Objective This study aims to investigate critical genes and pathways that may modulate the transdifferentiation from SESCs to CECs. Methods Isolated SESCs and CECs were used for gene expression analysis by microarray. GO and KEGG pathway of differently expressed genes (DEGs) were enriched using DAVID. The protein–protein interaction (PPI) network were then constructed using Cytoscape and highly interconnected module was subsequently isolated from the network by Molecular Complex Detection. Expression of the hub genes and other selected genes were then verified by qRT-PCR. Results We found 112 upregulated and 105 downregulated genes in CECs compared with SESCs. These DEGs were significantly enriched in focal adhesion, PI3K–Akt and TNF signaling pathway. Highly interconnected module of PPI network contains ten genes. Further regulatory network of these genes showed that ESR1 and SLC2A4 were hub genes. Conclusion Our study identified gene expression in SESCs and CECs and suggested that several crucial genes and pathways may play critical roles in transdifferentiation from SESCs to CECs. It may help uncover molecular mechanisms and offer a foundation for promoting tissue-engineered cornea into clinical application.
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Numerical study of rock-breaking performance of cutters in heterogeneous sand cobble ground
Jin Guo,Xiangwei Kong,Liu Cheng,Xueyi Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
Further research into tunneling performance in heterogeneous sand cobble ground demands an accurate numerical model of actual formation. In this paper, the ground model composed of spherical sand and ellipsoidal cobble was constructed to study the rockbreaking performance by using the discrete element method. The shape and physical parameters of sand and cobble were obtained on the basis of field test data. Then, the ground model was constructed to simulate the rock-breaking process of the cutterhead. The results show that the center cutter has a high flat wear percentage. With the decrease in cobble content (CC), the cracks between cutters are not connected effectively, thereby resulting in lower rock-breaking quantity. Finally, the influences of CC on the optimal parameters and crack propagation were analyzed. The results indicate that the rock-breaking performance in the ground with a low CC can be improved by increasing penetration and reducing cutter spacing.
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Fuhui Cui,Junjie Wang1,Xiangdong Gan,Dawei Yu,Ilya Vladimirovich Okulov,Qinghua Tian,Xueyi Guo 대한금속ᆞ재료학회 2023 METALS AND MATERIALS International Vol.29 No.2
Liquid Mg is capable of quickly eroding the refractory Ni-based superalloy and selectively dissolve Ni, which opens up anew avenue for the recycling of superalloy scraps for comprehensive metal reclamation. This study aims at investigating theunderlining mechanism and kinetics of the selective dissolution of Ni from Inconel 718 (one type of Ni-based superalloy)with liquid Mg, by experimenting at 750, 800, and 850 °C for various amounts of time in an inert atmosphere. This selectivedissolution process is also known as liquid metal dealloying. Results show that a permeable dealloyed layer was formedresulting from the preferential dissolution of Ni over other metallic elements (e.g., Fe, Cr, Nb, Mo, and Ti). At the dealloyingforefront, the grain boundaries of the matrix γ phase were preferentially eroded by liquid Mg. The opposite concentrationgradients of Ni (4–9 wt%) and Mg (12–18 wt%) cross the dealloyed layer suggested their counter diffusion. A higher heatingtemperature substantially increased the dealloying rate.
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Dealloying Superalloy by Liquid Mg for the Selective Extraction of Ni
Fuhui Cui,Junjie Wang,Xiangdong Gan,Dawei Yu,Ilya Vladimirovich Okulov,Qinghua Tian,Xueyi Guo 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.3
Liquid Mg is capable of quickly eroding the refractory Ni-based superalloy and selectively dissolve Ni, which opens up anew avenue for the recycling of superalloy scraps for comprehensive metal reclamation. This study aims at investigating theunderlining mechanism and kinetics of the selective dissolution of Ni from Inconel 718 (one type of Ni-based superalloy)with liquid Mg, by experimenting at 750, 800, and 850 °C for various amounts of time in an inert atmosphere. This selectivedissolution process is also known as liquid metal dealloying. Results show that a permeable dealloyed layer was formedresulting from the preferential dissolution of Ni over other metallic elements (e.g., Fe, Cr, Nb, Mo, and Ti). At the dealloyingforefront, the grain boundaries of the matrix γ phase were preferentially eroded by liquid Mg. The opposite concentrationgradients of Ni (4–9 wt%) and Mg (12–18 wt%) cross the dealloyed layer suggested their counter diffusion. A higher heatingtemperature substantially increased the dealloying rate.
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