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- 저자 : Xuefeng Shu (검색결과 2 건)
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Luo Jinlong,Yang Hua,Peng Xuefeng,Zhang Faqiang,Shu Shilong,Lan Ke,Tu Shengjin,Lu Kai,Cha Xiaoying 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.5
Background: Colorectal cancer (CRC) is a prevalent malignant tumor with poor prognosis. Circular RNAs (circRNAs) are key regulators in the progression of CRC. Our study aimed to disclose the role of circ_0000554 in CRC. Methods: The expression of circ_0000554, miR-1205 and LIM and SH3 protein 1 (LASP1) was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation, invasion and migration were monitored using cell counting kit-8 (CCK-8) assay, EdU assay, transwell assay and wound healing assay respectively. The protein levels of C-myc, matrix metallopeptidase 2 (MMP-2) and LASP1 were detected by western blot. Tumor formation assay in nude mice was conducted to explore the role of circ_0000554 in vivo. The association between miR-1205 and circ_0000554 or LASP1 was identified by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Results: circ_0000554 was upregulated in CRC tissues and cells, high circ_0000554 expression was significantly linked to shorter overall survival. Downregulation of circ_0000554 restrained cell growth and metastasis while promoted apoptosis in vitro, and suppressed tumorigenesis of CRC in vivo. Furthermore, mechanism study and rescue experiments confirmed miR-1205 could be sponged by circ_0000554 and its inhibitor reversed the inhibitory effect of circ_0000554 silencing on CRC progression. LASP1 was a target gene of miR-1205 and the upregulation of LASP1 overturned miR-1205-induced effects on CRC cells. Circ_0000554 could elevate LASP1 expression via interacting with miR-1205.
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A Criterion Describing the Dynamic Yield Behavior of PMMA
Ji Qiu,Tao Jin,Buyun Su,Qian Duan,Xuefeng Shu,Erqiang Liu,Xin Li 한국고분자학회 2019 Macromolecular Research Vol.27 No.8
Dynamic uniaxial and multiaxial tests were conducted to characterize the mechanical behavior of poly(methyl methacrylate) (PMMA). In this case, the multiaxial yield behavior of materials can be captured by the shear-compression samples (SCS). The experimental results were compared with different yield criteria, and which does not have a good agreement between theoretical prediction and experimental yield loci of PMMA undergoing combined shear-compression. Therefore, a phenomenological yield criterion is developed, and it notably involves hydrostatic stress sensitivity, lode angle, and one parameter. The parameter can be expressed by the asymmetry of yield strength between the tension and compression. The proposed criterion was verified by the utilization of differently combined shear-compression tests. The investigative results reveal that the proposed criterion can be successfully applied to describe the complex yield behavior of PMMA under dynamic loading conditions. The present study shows an efficient method to develop yield criterion of the reviewed materials.
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