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Danling Hu,Sijie Liao,Xue Chen,Jincao Du,Kamran Dawood,Sachin Chauhan,Chao Gao,Wei Li 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.7
A novel fluorescent probe TSA for the high selectivity of mercury (Hg2+) ion has been explored, which was obtained by two-step synthesis. Probe TSA was barely emissive in HEPES buffer. In the presence of Hg2+ ion, the dithioacetal unit in probe TSA was hydrolyzed to be formyl group, consequently causing the intense sky-blue emission via aggregation-induced emission and intramolecular charge transfer mechanisms. Moreover, probe TSA was potential to detect Hg2+ ion in dyeing wastewater and clay soil.
Roles of Fibroblast Growth Factor-inducible 14 in Hepatocellular Carcinoma
Li, Nan,Hu, Wen-Jun,Shi, Jie,Xue, Jie,Guo, Wei-Xing,Zhang, Yang,Guan, Dong-Xian,Liu, Shu-Peng,Cheng, Yu-Qiang,Wu, Meng-Chao,Xie, Dong,Liu, Shan-Rong,Cheng, Shu-Qun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
The prognostic value of the fibroblast growth factor-inducible 14 (Fn14) expression in hepatocellular carcinoma (HCC) is unknown. Real-time PCR (RT-PCR), western blot assays and immunohistochemistry analysis were here performed in order to compare Fn14 expressios in paired liver samples of HCC and normal liver tissue. Most of the tumor tissues expressed significantly higher levels of Fn14 compared to adjacent non-tumor tissues, with Fn14High accounting for 54.6% (142/260) of all patients. The Pearson ${\chi}^2$ test indicated that Fn14 expression was closely associated with serum alpha fetal protein (AFP) (P=0.002) and tumor number (p=0.019). Univariate and multivariate analyses revealed that along with tumor diameter and portal vein tumor thrombosis (PVTT ) type, Fn14 was an independent prognostic factor for both overall survival (OS) (HR=1.398, p=0.008) and recurrence (HR=1.541, p=0.001) rates. Fn14 overexpression HCC correlated with poor surgical outcome, and this molecule may be a candidate biomarker for prognosis as well as a target for therapy.