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RISS 인기검색어
- 검색키워드
- 저자 : Xinran Tian (검색결과 4 건)
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Calculation of dynamic stress intensity factors and T-stress using an improved SBFEM
Xinran Tian,Chengbin Du,Shangqiu Dai,Denghong Chen 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.66 No.5
The scaled boundary finite element method is extended to evaluate the dynamic stress intensity factors and T-stress with a numerical procedure based on the improved continued-fraction. The improved continued-fraction approach for the dynamic stiffness matrix is introduced to represent the inertial effect at high frequencies, which leads to numerically better conditioned matrices. After separating the singular stress term from other high order terms, the internal displacements can be obtained by numerical integration and no mesh refinement is needed around the crack tip. The condition numbers of coefficient matrix of the improved method are much smaller than that of the original method, which shows that the improved algorithm can obtain well-conditioned coefficient matrices, and the efficiency of the solution process and its stability can be significantly improved. Several numerical examples are presented to demonstrate the increased robustness and efficiency of the proposed method in both homogeneous and bimaterial crack problems.
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Calculation of dynamic stress intensity factors and T-stress using an improved SBFEM
Tian, Xinran,Du, Chengbin,Dai, Shangqiu,Chen, Denghong Techno-Press 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.66 No.5
The scaled boundary finite element method is extended to evaluate the dynamic stress intensity factors and T-stress with a numerical procedure based on the improved continued-fraction. The improved continued-fraction approach for the dynamic stiffness matrix is introduced to represent the inertial effect at high frequencies, which leads to numerically better conditioned matrices. After separating the singular stress term from other high order terms, the internal displacements can be obtained by numerical integration and no mesh refinement is needed around the crack tip. The condition numbers of coefficient matrix of the improved method are much smaller than that of the original method, which shows that the improved algorithm can obtain well-conditioned coefficient matrices, and the efficiency of the solution process and its stability can be significantly improved. Several numerical examples are presented to demonstrate the increased robustness and efficiency of the proposed method in both homogeneous and bimaterial crack problems.
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Four-Leg Object Recognition for Service Robot Based on Top-hat Transformation
Hao Wu,Guohui Tian,Xinran Wang,Fei Lu 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12
A method of object recognition for objects with special topological structure is developed based on top-hat transformation for service robot. The objects with four legs are easily detected and recognized by service robot with laser ranger array by this method. First, the top-hat transformation in one dimension is reviewed, then the recognition strategy of self-adapting threshold for objects with special topological structure is proposed, and the general data process for object recognition and position is proposed and analyzed. Experimental results show that the process of object recognition based on top-hat transformation proposed in this article is an effective and accurate application.
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Chengnan Li,Yingying Gan,Zongshao Li,Mengjing Fu,Yuzhen Li,Xinran Peng,Yongqiang Yang,Guo‑bao Tian,Yi Yan Yang,Peiyan Yuan,Xin Ding 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background P. aeruginosa, a highly virulent Gram-negative bacterium, can cause severe nosocomial infections, and it has developed resistance against most antibiotics. New therapeutic strategies are urgently needed to treat such bacterial infection and reduce its toxicity caused by endotoxin (lipopolysaccharide, LPS). Neutrophils have been proven to be able to target inflammation site and neutrophil membrane receptors such as Toll-like receptor-4 (TLR4) and CD14, and exhibit specific affinity to LPS. However, antibacterial delivery system based on the unique properties of neutrophils has not been reported. Methods A neutrophil-inspired antibacterial delivery system for targeted photothermal treatment, stimuli-responsive antibiotic release and endotoxin neutralization is reported in this study. Specifically, the photothermal reagent indocyanine green (ICG) and antibiotic rifampicin (RIF) are co-loaded into poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP-ICG/RIF), followed by coating with neutrophil membrane to obtain antibacterial delivery system (NM-NP-ICG/RIF). The inflammation targeting properties, synergistic antibacterial activity of photothermal therapy and antibiotic treatment, and endotoxin neutralization have been studied in vitro. A P. aeruginosa-induced murine skin abscess infection model has been used to evaluate the therapeutic efficacy of the NM-NP-ICG/RIF. Results Once irradiated by near-infrared lasers, the heat generated by NP-ICG/RIF triggers the release of RIF and ICG, resulting in a synergistic chemo-photothermal antibacterial effect against P. aeruginosa (~ 99.99% killing efficiency in 5 min). After coating with neutrophil-like cell membrane vesicles (NMVs), the nanoparticles (NM-NP-ICG/RIF) specifically bind to inflammatory vascular endothelial cells in infectious site, endowing the nanoparticles with an infection microenvironment targeting function to enhance retention time. Importantly, it is discovered for the first time that NMVs-coated nanoparticles are able to neutralize endotoxins. The P. aeruginosa murine skin abscess infection model further demonstrates the in vivo therapeutic efficacy of NM-NP-ICG/RIF. Conclusion The neutrophil-inspired antibacterial delivery system (NM-NP-ICG/RIF) is capable of targeting infection microenvironment, neutralizing endotoxin, and eradicating bacteria through a synergistic effect of photothermal therapy and antibiotic treatment. This drug delivery system made from FDA-approved compounds provides a promising approach to fighting against hard-to-treat bacterial infections.
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