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- 저자 : Xingyu Liang (검색결과 3 건)
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Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.
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Hanzhengnan Yu,Xingyu Liang,Gequn Shu 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.5
Wall wetting in the early injection period has been proved to be unavoidable in the HCCI (Homogeneous charge compression ignition) diesel engine using early injection strategy, which directly affects in-cylinder fuel-air mixture formation. In this study, the effects of the early injection parameters (injection timing, injection angle and injection pressure) on wall wetting characteristics of an HCCI diesel engine using early injection strategy have been numerically investigated. The variations of maximum wall film mass, evaporated wall film mass and residual wall film mass have been summarized. The concept of MHI (Mixture Homogenous Index) is introduced to evaluate the homogeneity of fuel-air mixture in the wall wetting region. In additions, the effects of the early injection parameters on the HC (Hydrocarbon Compounds) and CO (Carbon Monoxide) emissions have also been discussed. Results showed that in order to decrease the HC and CO emission caused by wall wetting as low as possible, it was better to increase the injection pressure and to advance the injection timing. The most effective method was to narrow the injection angle, In addition, the impingement target should be considered for choosing the injection timing and injection angle, and the impingement target of the piston bowl lip was recommended due to the enhancement of the atomization and the higher surface temperature.
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Experimental Study on the Ultralow Cycle Fatigue Performance of Bolted Spherical Joint Specimens
Yanying Li,Haiwang Li,Pengliang Liang,Xingyu Wang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.3
Under disastrous earthquake conditions, the bolted spherical joints in spatial steel grid structures are prone to bending, breaking, and other failure modes, and their failure has obvious ultralow cycle fatigue failure characteristics. In this paper, quasistatic tests were carried out on three groups (nine specimens in total) of bolted spherical joints with joints at both ends under uniaxial cyclic loading. The failure characteristics, hysteretic behaviour, bearing capacity degradation, stiffness degradation, and energy compression capacity of bolted spherical joints under three loading schemes were studied. At the same time, the change rule of the rotation angle with the number of cycles was obtained. The experimental study shows that each member experiences characteristic moments of high-strength bolt bending, cracking, crack propagation, and a loud crack and that bolt failure occurs at the middle bolt ball connection. The ultimate ultralow cycle fatigue failure of the specimen occurs after more than 10 cycles, and the energy compression capacity is poor due to the small volume of high-strength bolts and sleeves. The "pinching phenomenon" of the hysteresis curve of the bolted spherical joint is serious. The tension area of the hysteresis curve increases, and the fullness of the compression area decreases, with increasing tensile amplitude. Based on the cumulative energy compression, a damage model suitable for bolted spherical joints under cyclic loading is proposed. From the experimental data, a correlation formula between the angle change rate and the damage model was established when the middle bolt ball of the connection specimen experienced a tension–compression cyclic load. This formula provides a reference for the evaluation of bolted spherical joints of bolt ball grid structures after an earthquake.
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