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RISS 인기검색어
- 검색키워드
- 저자 : Xing-Quan Guan (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Protective Effects of Chalcone Derivatives for Acute Liver Injury in Mice
Guan Li-Ping,Nan Ji-Xing,Jin Xue-Jun,Jin Qing-Hao,Kwak Kyung Chell,Chai Kyu-yun,Quan Zhe-Shan The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.1
The hepatoprotective effects of chalcone derivatives were evaluated in D-galactosamine/lipopolysaccharide (D-GaIN/LPS)-induced fulminant hepatic failure in mouse. Thirteen chalcone derivatives were synthesized for study and their hepatoprotective effects were evaluated by assessing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum. Chalcone preparations were injected into mice at 12 hand 1 h before intraperitoneal injection of D-GaIN/LPS. After abdominal administration, changes in AST and ALT between the control and treated groups were observed. Ten of the synthesized chalcone derivatives exhibited inhibitory effects on D-GaIN/LPS-induced levels of AST and ALT in mice. Compounds 2, 3, 8, 9, and 12 markedly reduced serum AST and ALT at 8 h, inhibited hepatocyte necrosis and showed significant hepatoprotective activities. The activity of compound 3 was compared with the bifendate (DDB) through oral administration. Compound 3 showed much higher inhibitory effects than bifendate for decreasing AST and ALT activity. The results indicate that compound 3 has strong hepatoprotective activity through suppression of tumor necrosis factoralpha (TNF-alpha) preduction, reduction of the histological change in the liver, and attenuated of hepatocyte apoptosis confirmed by DNA fragmentation assay.
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Protective Effects of Chalcone Derivatives for Acute Liver Injury in Mice
Li-Ping Guan,Ji-Xing Nan,Xue-Jun Jin,Qing-Hao Jin,곽경철,채규윤,Zhe-Shan Quan 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.1
The hepatoprotective effects of chalcone derivatives were evaluated in D-galactosamine/ lipopolysaccharide (D-GalN/LPS)-induced fulminant hepatic failure in mouse. Thirteen chalcone derivatives were synthesized for study and their hepatoprotective effects were evaluated by assessing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum. Chalcone preparations were injected into mice at 12 h and 1 h before intraperitoneal injection of D- GalN/LPS. After abdominal administration, changes in AST and ALT between the control and treated groups were observed. Ten of the synthesized chalcone derivatives exhibited inhibitory effects on D-GalN/LPS-induced levels of AST and ALT in mice. Compounds 2, 3, 8, 9, and 12 markedly reduced serum AST and ALT at 8 h, inhibited hepatocyte necrosis and showed significant hepatoprotective activities. The activity of compound 3 was compared with the bifendate (DDB) through oral administration. Compound 3 showed much higher inhibitory effects than bifendate for decreasing AST and ALT activity. The results indicate that compound 3 has strong hepatoprotective activity through suppression of tumor necrosis factoralpha (TNF-alpha) preduction, reduction of the histological change in the liver, and attenuated of hepatocyte apoptosis confirmed by DNA fragmentation assay.
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Experimental Investigation on the Fatigue Behaviour of Heat-Treated Tubular T-Joints
Hazem Samih Mohamed,Fei Gao,Xing-Quan Guan,Hong Ping Zhu 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.7
The stress distribution along the weld toe (SCF test) and the fatigue life of tubular T-joints (Fatigue test) were experimentallyinvestigated in this study. Three specimens with identical geometric properties were tested to failure under fatigue cyclic loading atthe brace end. Prior to the loading tests procedure, SCF and Fatigue tests, two specimens went through one cycle of heating andcooling naturally. The SCF test results showed that the maximum Stress Concentration Factor (SCF) occurred at the chord saddle forall the specimens. The fatigue cracks were initiated at the chord saddles of the three tested specimens. The fatigue test results showedthat the fatigue life was longer the higher the target maximum temperature was. The development of the crack aspect ratio with thenormalised crack length was discussed among the specimens. Finally, the fatigue life results obtained from the experiment comparedwith those from CIDECT and API guidelines.
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