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        Improvement on the Structure Design of A Kind of Linear Piezoelectric Motor with Flexible Drive-foot

        Xifu Chen,Ming Li,Huixia Zhang,Qian Lu,류성기 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.1

        Linear piezoelectric motors have wide application prospects in precision instrument, biomedical engineering and many other high technology fields. In this paper, a linear piezoelectric motor operating in non-resonant state was proposed by using a flexible mechanism with characteristics of precision displacement output. Since the stator structural characteristic affects the stability and output performance of the motor directly, this paper focused on the improvement on the structure design of a motor stator with flexible five-bar drive-foot. Firstly, by analyzing the displacement output characteristics of flexible five-bar mechanism, the elliptical trajectory of drive-tip was investigated. Then the drive-foot was particularly designed with the characteristics of flexible structure, and its main structure parameters ware improved by the finite element method. Further, the integrated structure of stator was designed and fabricated. Finally, the comparison tests of the two motors were carried out. The experimental results show that the output force and efficiency of the improved piezoelectric motor are increased by 52.38% and 159.15%, respectively.

      • KCI등재

        CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex

        Chen Kun,Chen Xi,Lang Chuandong,Yuan Xingshi,Huang Junming,Li Zhi,Xu Mingyou,Wu Kerong,Zhou Chenhe,Li Qidong,Zhu Chen,Liu Lianxin,Shang Xifu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

        The identification of key regulatory factors that control osteoclastogenesis is important. Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional entities. However, the complexities of circRNA expression as well as the extent of their regulatory functions during osteoclastogenesis have yet to be revealed. Here, based on circular RNA sequencing data, we identified a circular RNA, circFam190a, as a critical regulator of osteoclast differentiation and function. During osteoclastogenesis, circFam190a is significantly upregulated. In vitro, circFam190a enhanced osteoclast formation and function. In vivo, overexpression of circFam190a induced significant bone loss, while knockdown of circFam190a prevented pathological bone loss in an ovariectomized (OVX) mouse osteoporosis model. Mechanistically, our data suggest that circFam90a enhances the binding of AKT1 and HSP90β, promoting AKT1 stability. Altogether, our findings highlight the critical role of circFam190a as a positive regulator of osteoclastogenesis, and targeting circFam190a might be a promising therapeutic strategy for treating pathological bone loss.

      • KCI등재

        A Novel Parallel Precision Stage with Large Working Range Based on Structural Parameters of Flexible Hinges

        Qian Lu,Xifu Chen,Lei Zheng,Ning Xu 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.3

        In order to solve the inherent contradiction of high precision and large working range in the traditional parallel positioning stage, a novel parallel precision stage with large working range based on optimized flexible hinge was studied. Firstly, a new structure parameter Ps was proposed, and its influence on the rotation stiffness was analyzed by comparing the commonly used flexible hinges. The factors that could enlarge the rotation ability were summarized, and the cylindrical flexible hinge with large working range was optimized. Then the cylindrical flexible hinge was used to constructed a novel parallel precision positioning stage, which could realize both of high resolution and large working range by taking use of the step and continuous motion of the piezoelectric actuators. The experiment results show that the resolution of translation is 0.09 μm, and the rotation resolution are 0.8 μrad, 0.9 μrad and 1.0 μrad, respectively. While the working range of the parallel stage could achieve 120 mm for translation, and 6.18°, 6.74° and 6.58°, respectively for each axis of rotation. All of the basic research contents is helpful for further study of the control laws of the compliant parallel mechanism.

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