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- 저자 : Xiaofan Guo (검색결과 3 건)
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The FvCYP714C2 gene plays an important role in gibberellin synthesis in the woodland strawberry
Xiaofan Guo,Zhibing Xie,Yang Zhang,Shouming Wang 한국유전학회 2021 Genes & Genomics Vol.43 No.1
Background Fragaria vesca, the woodland strawberry, is a diploid relative of the cultivated strawberry. A GA-defcient mutant was found in ethyl methanesulfonate (EMS)-mutagenized lines of the Fragaria vesca accession ‘Yellow Wonder’. Objective CYP714C2 was found to be diferentially expressed using RNA-seq analysis. It is necessary to identify the function of this gene. Methods In order to identify the function of this gene, it was cloned and transformed into Arabidopsis thaliana. Results The DNA sequence of CYP714C2 was found to be 1940 bp in length, with an open reading frame (ORF) of 1539 bp that is predicted to encode a protein of 512 amino acids. The hydrophilicity of this protein is low and it is unstable. The highest relative expression of FvCYP714C2 was found in the leaves, followed by the pedicels, and low expression levels were found in the other tissues examined. Constitutive expression of FvCYP714C2 signifcantly promoted the growth of transgenic A. thaliana plants; transgenic Arabidopsis plants grew faster and grew well than wild type Col-0 plants. GA1+3 contents of the genetically modifed Arabidopsis lines were signifcantly higher than that in the wild type. Conclusion We conclude that FvCYP714C2 is a gene that functions in the gibberellin biosynthesis pathway in strawberry.
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A potential red-emitting phosphor with high color-purity for near-UV light emitting diodes
Zhengliang Wang,Yaling Zhang,Li Xiong,Xiaofan Li,Junming Guo,Menglian Gong 한국물리학회 2012 Current Applied Physics Vol.12 No.4
New red tungstates phosphors, Na5La1-xLnx(WO4)4 (Ln = Eu, Sm) and Na5Eu1-xSmx(WO4)4, were prepared by solid-state reaction technique. And their structure and photo-luminescent properties were investigated. The introduction of Sm3+ broadened the excitation band around 400 nm of the phosphors,and strengthened the red emission. And the possible energy transfer process from Sm3þ to Eu3+ is discussed. The single red LED was fabricated by combining InGaN chip with Na5Eu0.94Sm0.06(WO4)4 as red phosphor, intense red light can be observed by naked eyes. Then the phosphor Na5Eu0.94Sm0.06(WO4)4 may be a good candidate for red component of near-UV InGaN-based W-LEDs,because of efficient red-emitting with broadened absorption around 400 nm and appropriate CIE chromaticity coordinates (x = 0.65, y = 0.34).
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Fei Xiaowei,Dou Ya-nan,Sun Kai,Wei Jialiang,Guo Qingdong,Wang Li,Wu Xiuquan,Lv Weihao,Jiang Xiaofan,Fei Zhou 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationship between TRIM22 and MAPK signaling remains unclear. Here, we found that TRIM22 binds to exon 2 of the sphingosine kinase 2 (SPHK2) gene. An ERK1/2-driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. Knockout and overexpression of TRIM22 regulate the inhibition and activation of MAPK signaling through the RING-finger domain. TRIM22 binds to Raf-1, a negative regulator of MAPK signaling, and accelerates its degradation by inducing K48-linked ubiquitination, which is related to the CC and SPRY domains of TRIM22 and the C1D domain of Raf-1. In vitro and in vivo, an SPHK2 inhibitor (K145), an ERK1/2 inhibitor (selumetinib), and the nonphosphorylated mutant Raf-1S338A inhibited GBM growth. In addition, deletion of the RING domain and the nuclear localization sequence of TRIM22 significantly inhibited TRIM22-induced proliferation of GBM cells in vivo and in vitro. In conclusion, our study showed that TRIM22 regulates SPHK2 transcription and activates MAPK signaling through posttranslational modification of two critical regulators of MAPK signaling in GBM cells.
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