http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Xiaodong Zhuang (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Minnan Yang,Zhuang Ding,Qun Xiang,Xiaodong Zhang,Xiang Li,Seydou Sylla 한국미생물학회 2014 The journal of microbiology Vol.52 No.4
Porcine reproductive and respiratory syndrome (PRRS) is animportant disease, which leads to severe economic losses inswine-producing areas of the world. However, current antiviralstrategies cannot provide highly effective protection. In this study, three theoretically effective interference targetsites (71-91, 144-164, 218-238) targeting the nucleocapsid (N)gene of PRRSV were designed and selected, and then threesiRNA-expressing plasmids were constructed, respectivelynamed p2.1-N71, p2.1-N144, and p2.1-N218. The recombinantsiRNA-expressing plasmids were transfected into Marc-145 cells; then the cells were infected with PRRSV (JL07SWstrain); finally, after incubation for 48 h, the antiviral activityof those siRNA-expressing plasmids in Marc-145 cells wasassessed by cytopathic effects, virus titers, indirect immunofluorescence,and quantitative real-time PCR. Experimentalresults demonstrated that these three siRNA-expressing plasmidscould effectively and significantly inhibit the replicationof PRRSV by 93.2%, 83.6%, and 89.2% in Marc-145 cells,respectively. Among these three siRNA-expressing plasmids,p2.1-N71 was found to be most effective, while p2.1-N144and p2.1-N218 displayed relatively weak inhibition of virusreplication. The results indicated that siRNA-expressing plasmidstargeting the N gene of PRRSV could significantly inhibitPRRSV replication in Marc-145 cells. Based on our experimentalresults and previous reports, the 71-91, 179-197,and 234-252 sites of the N gene are good choices to effectivelyinhibit the replication of PRRSV, and this RNA interferencetechnique can be a potential anti-PRRSV strategy.
-
Hou, Yang,Qiu, Ming,Nam, Gyutae,Kim, Min Gyu,Zhang, Tao,Liu, Kejun,Zhuang, Xiaodong,Cho, Jaephil,Yuan, Chris,Feng, Xinliang American Chemical Society 2017 NANO LETTERS Vol.17 No.7
<P>Developing highly active electrocatalysts for photoelectrochemical water splitting is critical to bring solar/electrical-to-hydrogen energy conversion processes into reality. Herein, we report a three-dimensional (3D) hybrid electrocatalyst that is constructed through in situ anchoring of Co9S8 nanosheets onto the surface of Ni3Se2 nanosheets vertically aligned on an electrochemically exfoliated graphene foil. Benefiting from the synergistic effects between Ni3Se2 and Co9S8, the highly conductive graphene support, and large surface area, the novel 3D hybrid electrode delivers superior electrocatalytic activity toward water reduction in alkaline media, featuring overpotentials of -0.17 and -0.23 V to achieve current densities of 20 and 50 mA cm(-2), respectively, demonstrating an electrocatalytic performance on the top of the Ni3Se2- and Co9S8-based electrocatalysts as reported in literature. Experimental investigations and theoretical calculations confirm that the remarkable activity of the obtained material results from the unique 3D hierarchical architecture and interface reconstruction between Ni3Se2 and Co9S8 through Ni-S bonding, which leads to charge redistribution and thus lowers the energy barrier of hydrogen desorption in the water splitting process. Further integration of the 3D hybrid electrode with a macroporous silicon photocathode enables highly active and sustainable sunlight-driven water splitting in both basic media and real river water. The overall water splitting with 10 mA cm(-2) at a low voltage of 1.62 V is achieved using our hybrid as both anode and cathode catalysts, which surpasses that of the Ir/C-Pt/C couple (1.60 V) for sufficiently high overpotentials.</P>
-
Menghui Liu,Shaozhao Zhang,Xiaohong Chen,Yue Guo,Xiangbin Zhong,Zhenyu Xiong,Yifen Lin,Huimin Zhou,Yiquan Huang,Zhengzhipeng Zhang,Lichun Wang,Xiaodong Zhuang,Xinxue Liao 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.5
Background: Currently available guidelines contain conflicting recommendations on the management of blood pressure (BP) in patients with diabetes mellitus (DM). Therefore, it is necessary to appraise the guidelines and summarize the agreements and differences among recommendations.Methods: Four databases and the websites of guideline organizations were searched for guidelines regarding BP targets and thresholds for pharmacologic therapy in DM patients, and the included guidelines were appraised with the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument.Results: In 6,498 records identified, 20 guidelines met our inclusion criteria with 64.0% AGREE II scores (interquartile range, 48.5% to 72.0%). The scores of the European and American guidelines were superior to those of the Asian guidelines (both adjusted P<0.001). Most of the guidelines advocated systolic BP targets <130 mm Hg (12 guidelines, 60%) and diastolic BP targets <80 mm Hg (14 guidelines, 70%) in DM patients. Approximately half of the guidelines supported systolic BP thresholds >140 mm Hg (10 guidelines, 50%) and diastolic BP thresholds >90 mm Hg (nine guidelines, 45%). The tiny minority of the guidelines provided the relevant recommendations regarding the lower limit of official BP targets and the ambulatory BP monitoring (ABPM)/home BP monitoring (HBPM) targets and thresholds in DM patients.Conclusion: The lower official BP targets (<130/80 mm Hg) in patients with DM are advocated by most of the guidelines, but they contain conflicting recommendations on the official BP thresholds. Moreover, the gaps regarding the lower limit of official BP targets and the ABPM/HBPM targets and thresholds need to be considered by future study.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
