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Synthesis of Dithiolopyrrolone Derivatives and Their Leukocyte-Increasing Activities
Li, Chungang,Sun, Yiping,Wang, Guoping,Tan, Xiangduan Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds 4, 9 and 16 had a moderate effect ( p < 0.05). Compound 5 also displayed stronger leukocyte-increasing activity than that of the positive recombinant human granulocyte colony stimulating factor (rhG-CSF). Above all, compound 5 would be a potential antileukopenia agent which deserved further research.
Synthesis of Dithiolopyrrolone Derivatives and Their Leukocyte-Increasing Activities
Chungang Li,Yiping Sun,Guoping Wang,Xiangduan Tan 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds 4, 9 and 16 had a moderate effect ( p < 0.05). Compound 5 also displayed stronger leukocyte-increasing activity than that of the positive recombinant human granulocyte colony stimulating factor (rhG-CSF). Above all, compound 5 would be a potential antileukopenia agent which deserved further research.