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- 저자 : Xiang Dong Ye (검색결과 4 건)
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A Highly Stretchable, Sensitive Strain Sensor Based on the Dry Printing Method
Xiang Dong Ye,Jie Li,Jia Wei Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.9
Use of Electronic skin (E-skin) has attracted significant attention, as it has broad application prospects in medical care, wearable electronic equipment, and body monitoring — particularly with respect to human motion detection. In this work, we developed a flexible, tensile strain sensor based on the dry printing method. A conductive layer, with a miniaturized network structure, was obtained by: (1) packing the grooves of a grid-like silicon template with a conductive powder composed of carbon nanotubes (CNTs) and silicon dioxide (SiO2) nanoparticles; (2) infiltrating liquid polydimethylsiloxane (PDMS) into the powder voids using a coated, flexible PDMS substrate cover; (3) transferring the solidified, patterned conductive powder onto the flexible substrate by peeling the PDMS substrate cover off the template; (4) fabricating metal electrodes at both ends of the conductive layer and (5) encapsulating the strain sensor with liquid PDMS. After manufacture, the strain sensor was tested using the tensile test. Results from the tensile test demonstrate that the sensor has excellent electrical conductivity, including super high-sensitivity (GF > 1450), a large strain range (up to 35%), and good transparency; as ultraviolet (UV) spectrum analysis shows that the transmittance can reach > 60%. Thus, the sensor is potentially applicable to numerous sub-specialties that require specialized electronics.
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Zhi, Ai-Min,Feng, Ding-Yuan,Zhou, Xiang-Yan,Zou, Shi-Geng,Huang, Zhi-Yi,Zuo, Jian-Jun,Ye, Hui,Zhang, Chang-Ming,Dong, Ze-Min,Liu, Zhun Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.8
Cationic amino acid transporter $b^{0,+}AT$ (HGMW-approved gene symbol SLC7A9, solute carrier family 7, member 9) plays a crucial role in amino acid nutrition. In the present study, we describe the cloning and sequencing of porcine $b^{0,+}AT$. Based on the sequence of porcine $b^{0,+}AT$ deposited in the NCBI (National Center for Biotechnological Information), we identified a putative porcine homologue. Using rapid amplification of cDNA ends (RACE), the full-length cDNA encoding porcine $b^{0,+}AT$ was isolated. The porcine $b^{0,+}AT$ cDNA was 1,680 bp long, encoding a 487 amino acid trans-membrane protein. The predicted amino acid sequence was found to have 88.9% and 87.1% identity with human and mouse $b^{0,+}AT$, respectively. Real-time RT-PCR indicated porcine $b^{0,+}AT$ transcripts expressed in heart, kidney, muscle and small intestine. The small intestine had the highest $b^{0,+}AT$ mRNA abundance while the muscle had the lowest (p<0.05). Along the longitudinal axis, the ileum had the highest $b^{0,+}AT$ mRNA abundance while the colon had the lowest (p<0.05). The $b^{0,+}AT$ mRNA level was highest on day 7 and 90 in the duodenum (p<0.05). It increased from day 1 to day 26 in the jejunum (p>0.05) and had the highest abundance on day 60 (p<0.05). There was, however, no difference between day 1, 7, 26, 30, 90 and 150 (p>0.05). The strongest $b^{0,+}AT$ expression appeared on day 7 in the ileum before weaning, and then decreased till day 30 but rose gradually again from day 60 to 150 (p<0.05).
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Han, Yo-Han,Kee, Ji-Ye,Park, Seong-Hwan,Mun, Jeong-Geon,Jeon, Hee-Dong,Park, Jinbong,Zou, Qin-Peng,Liu, Xiang-Qian,Hong, Seung-Heon Elsevier 2019 Phytomedicine Vol.62 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Although rubrofusarin-6-β-gentiobioside (RFG), which is a component of <I>Cassiae tora</I> seed, could likely regulate hyperlipidemia, its anti-obesity effect and related mechanism have not been elucidated.</P> <P><B>Purpose</B></P> <P>The aim of this study was to examine whether RFG can ameliorate obesity and the mechanism of lipid accumulation regulated by RFG.</P> <P><B>Study design</B></P> <P>In <I>in vitro</I> experiments, we confirmed the anti-adipogenic effect of RFG using 3T3-L1 cells and human adipose mesenchymal stem cells (hAMSCs). To confirm the anti-obesity effect, High-Fat Diet (HFD)-induced obese mice were selected as a model.</P> <P><B>Methods</B></P> <P>We investigated anti-adipogenic effects of RFG using MTS assay, Oil Red O Staining, real-time RT-PCR, western blot analysis, and immunofluorescence staining. The anti-obesity effect of RFG was confirmed in HFD-induced mice model using hematoxylin and eosin staining and serum analysis.</P> <P><B>Results</B></P> <P>RFG inhibited lipid accumulation in 3T3-L1 cells and hAMSCs by reducing expression of mammalian targets of rapamycin (mTOR), peroxisome proliferator-activated receptor (PPAR)γ, and CCAAT-enhancer binding protein (C/EBP)α. RFG phosphorylated AMP-activated protein kinase (AMPK) in a liver kinase B (LKB) 1-independent manner. Moreover, the anti-adipogenic effect of RFG was blocked by AMPK inhibitor. These results suggest that RFG inhibits lipid accumulation via AMPK signaling. Furthermore, RFG reduced the body weight, size of epididymal white adipose tissue (eWAT), and fatty liver in the mice. RFG also suppressed levels of adipogenic factors PPARγ, C/EBPα, FAS, LPL, and aP2) by activating AMPK in the eWAT and liver.</P> <P><B>Conclusion</B></P> <P>RFG can ameliorate obesity, and thus, could be used as a therapeutic agent for treating obesity.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Jia, Yao,Hu, Ting,Hang, Chuan-Ying,Yang, Ru,Li, Xiong,Chen, Zhi-Lan,Mei, Ye-Dong,Zhang, Qing-Hua,Huang, Ke-Cheng,Xiang, Qun-Ying,Pan, Xiu-Yu,Yan, Yu-Ting,Wang, Xiao-Li,Wang, Shao-Shuai,Hang, Zhou,Tang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Purpose: To investigate the diet of patients with cervical cancer and precancerosis in the Wufeng area, a high-incidence region in China. Methods: In the case group, 104 patients diagnosed with cervical cancer or cervical intraepithelial neoplasias (CINII/III) were recruited from the Wufeng area. Nine hundred thirty-six healthy women were selected from the same area as the matched controls. A questionnaire, which included questions about general lifestyle conditions, smoking and alcohol status, source of drinking water, green tea intake, and diet in the past year, was presented to all participants. Results: Green tea intake (P=0.022, OR=0.551, 95% CI=0.330-0.919) and vegetable intake (P=0.035, OR=0.896, 95% CI=0.809-0.993) were identified as protective factors against cervical cancer or CINII/III. There was no indication of any associations of other lifestyle factors (smoking status, alcohol status, source of drinking water) or diet (intake of fruit, meat/egg/milk, soybean food, onion/garlic, staple food and pickled food) with cervical cancer. Conclusions: The results suggest that eating more fresh vegetables and drinking more green tea may help to reduce the risk of cervical cancer or CINII/III in people of the Wufeng area.
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