Wavelet-transform-based damping identification of a super-tall building under strong wind loads

An Xu,Jiurong Wu,Ruohong Zhao 한국풍공학회 2014 Wind and Structures, An International Journal (WAS Vol.19 No.4

A new method is proposed in this study for estimating the damping ratio of a super tall building under strong wind loads with short-time measured acceleration signals. This method incorporates two main steps. Firstly, the power spectral density of wind-induced acceleration response is obtained by the wavelet transform, then the dynamic characteristics including the natural frequency and damping ratio for the first vibration mode are estimated by a nonlinear regression analysis on the power spectral density. A numerical simulation illustrated that the damping ratios identified by the wavelet spectrum are superior in precision and stability to those values obtained from Welch’s periodogram spectrum. To verify the efficiency of the proposed method, wind-induced acceleration responses of the Guangzhou West Tower (GZWT) measured in the field during Typhoon Usagi, which affected this building on September 22, 2013, were used. The damping ratios identified varied from 0.38% to 0.61% in direction 1 and from 0.22% to 0.59% in direction 2. This information is expected to be of considerable interest and practical use for engineers and researchers involved in the wind-resistant design of super-tall buildings.

Amplitude dependency of damping of tall structures by the random decrement technique

An Xu,Zhuangning Xie,Ming Gu,Jiurong Wu 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.2

This study focuses on the amplitude dependency of damping of tall structures by the random decrement technique (RDT). Many researchers have adopted RDT to establish the amplitude dependency of damping ratios in super-tall buildings under strong wind loads. In this study, a series of simulated examples were analyzed to examine the reliability of this method. Results show that damping ratios increase as vibration amplitudes increase in several cases; however, the damping ratios in the simulated signals were preset as constants. This finding reveals that this method and the derived amplitude-dependent damping ratio characteristics are unreliable. Moreover, this method would obviously yield misleading results if the simulated signals contain Gaussian white noise. Full-scale measurements on a super-tall building were conducted during four typhoons, and the recorded data were analyzed to observe the amplitude dependency of damping ratio. Relatively wide scatter is observed in the resulting damping ratios, and the damping ratios do not appear to have an obvious nonlinear relationship with vibration amplitude. Numerical simulation and field measurement results indicate that the widely-used method for establishing the amplitude-dependent damping characteristics of super-tall buildings and the conclusions derived from it might be questionable at the least. More field-measured data must be collected under strong wind loads, and the damping characteristics of super-tall buildings should be investigated further.

HCV-Specific Interleukin-21+CD4+ T Cells Responses Associated with Viral Control through the Modulation of HCV-Specific CD8+ T Cells Function in Chronic Hepatitis C Patients

Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4

Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.

일반논문 : 抗戰時期吳鼎昌與州的經濟社會發展

임서무 ( Xu Wu Lin ) 東亞大學校附設 石堂傳統文化硏究院 2011 石堂論叢 Vol.0 No.51

항전시기 오정창은 귀주성 정부 주석직을 7년간 맡아 보면서 다양한 정책을 통해 귀주의 발전을 촉진하였다. 위생 보건, 금연, 군사훈련, 그리고 체육 등의 분야에 많은 노력을 기울였으며, 인구의 증가와 의식 수준의 향상을 위해 노력하였다. 농업과 임업 목축업과 양잠업, 전기 및 광공업, 교통과 운수 등의 사업을 통해 귀주기업주식회사를 설하여 공업화의 길을 모색하였다. 현장(縣長)의 선발 과정과 조직 정비, 현 정부와 향진 간의 권리와 책임을 구분하여 기층의 민주 정치를 발전시켰다. 이러한 시책은 남경 국민정부의 통치를 옹호하는 것이었으며, 또한 귀주의 현대화를 추진함으로써 후방을 튼튼히 하여 항전의 승리에 일정 정도 공헌함으로써 새로운 정치학 체계의 정치적 주장과 역사적 가치를 잘 보여주고 있다. Wu Ding-chang had been undertaken the government chairman in Guizhou province for seven years during the Anti-Japanese War. He took some policies of sanitation, anti-smoking, military training and physical education to increase the population. At the same time, he also used methods of school education and administration training to enhance population`s quality. And he initiated a new path of industrialization by developing agriculture, forestry, animal husbandry, raising silk worms, electricity, industry, mining and transportation and setting up Guizhou enterprise stock corporation. Moreover, he improved the methods of choosing the head of a county and ranks building, divided the rights and responsibilities between county and small towns and developed skeleton democratic politics. These policies impelled the economic and social modernization in Guizhou and made great contributions for consolidating Kuomintang-controlled areas and supporting the victory during the Anti-Japanese War.

CHMP1A suppresses the growth of renal cell carcinoma cells via regulation of the PI3K/mTOR/p53 signaling pathway

Wu Youping,Wu Yueguo,Xu Cong,Sun Wei,You Zhenqiang,Wang Yin,Zhang Sheng 한국유전학회 2022 Genes & Genomics Vol.44 No.7

Background: CHMP1A, a member of the ESCRT-III complex family, has been indicated as a brand-new inhibitor gene of tumors. Our previous research has revealed that CHMP1A plays a vital role in the development and progression of renal cell carcinoma (RCC). Objective: To investigate the potential target pathway of the regulation of the tumor cell growth by CHMP1A. Methods: The effect of CHMP1A on mTOR pathway was elucidated by western blotting. The effect of CHMP1A on the expression of p53 was evaluated, and A498 cell growth was assessed by colony formation and MTT assays. The expression of p53 was knocked down by shRNA-p53, and the effect of CHMP1A on mTOR after knockdown of p53 was evaluated. The effect of CHMP1A on apoptosis and its relationship with MDM2 pathway were detected by western blotting and FCM. Finally, the relationship between the regulation of p53 by CHMP1A and the PI3K/mTOR pathway was detected. Results: This study showed that the mTOR pathway was suppressed significantly in CHMP1A-overexpressing A498 and 786-0 cells; moreover, the enhanced expression of p53 and the reduced proliferation were shown in CHMP1A-overexpressing A498 cells. Furthermore, CHMP1A was able to regulate the PI3K/PTEN/mTOR and MDM2/p53 pathways in order to suppress RCC. In addition, CHMP1A regulated Bax and Bcl-2 via MDM2/p53 to induce the apoptosis of tumor cells and upregulated the expression of p53 via the PI3K/mTOR pathway. Conclusions: The results convey that CHMP1A-related suppression of RCC is closely related to the PI3K/mTOR/p53 pathway.

A Study on the Construction of “Life-production- e cology” space of Golf Course in China

Xu Jin,Xu Hao Long,Wang Jin Long,Tan Hao Yu,Yan Hong,Jing Wen Wu 한국글로벌무역학회 2022 한국글로벌무역학회 학술대회자료집 Vol.2022 No.-

Mortality Characteristic and Prediction of Nasopharyngeal Carcinoma in China from 1991 to 2013

Xu, Zhen-Xi,Lin, Zhi-Xiong,Fang, Jia-Ying,Wu, Ku-Sheng,Du, Pei-Ling,Zeng, Yang,Tang, Wen-Rui,Xu, Xiao-Ling,Lin, Kun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: To analyze the mortality distribution of nasopharyngeal carcinoma in China from 1991 to 2013, to predict the mortality in the ensuing five years, and to provide evidence for prevention and treatment of nasopharyngeal carcinoma. Materials and Methods: Mortality data for Nasopharyngeal Carcinoma in China from 1991 to 2013 were used to describe its epidemiological characteristics, such as the change of the standardized mortality rate, sex and age differences, urban-rural differences. Trend-surface analysis was used to study the geographical distribution of the mortality. Curve estimation, time series, gray modeling, and joinpoint regression were used to predict the mortality for the ensuing five years in the future. Results: In China, the standardized mortality rate of Nasopharyngeal Carcinoma increased with time from 1996, reaching the peak values of $1.45/10^5$ at the year of 2002, and decreased gradually afterwards. With males being 1.51 times higher than females, and the city had a higher rate than the rural during the past two decades. The mortality rate increased from age 40. Geographical analysis showed the mortality rate increased from middle to southern China. Conclusions: The standardized mortality rate of Nasopharyngeal Carcinoma is falling. The regional disease control for Nasopharyngeal Carcinoma should be focused on Guangdong province of China, and the key targets for prevention and treatment are rural men, especially after the age of 40. The mortality of Nasopharyngeal Carcinoma will decrease in the next five years.

Expression and Significance of Microsomal Prostaglandin Synthase-1 (mPGES-1) and Beclin-1 in the Development of Prostate Cancer

Xu, Lu-Wei,Qian, Ming,Jia, Rui-Peng,Xu, Zheng,Wu, Jian-Ping,Li, Wen-Cheng,Huang, Wen-Bin,Chen, Xing-Guo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

The aim of this study was to investigate the expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer (PCa). Immunohistochemistry was performed on paraffin-embedded sections with rabbit polyclonal against mPGES-1 and Beclin-1 in 40 PCa, 40 benign prostatic hyperplasia (BPH) and 10 normal prostate specimens for this purpose. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied for mRNA expression of mPGES-1 and Beclin-1, while MTT assays were used to ascertain the best working concentration of the mPGES-1 inhibitor (CAY10526). The effect of CAY10526 treatment on expression of Beclin-1 in DU-145 cells was studied using Western blot analysis. Localization of Beclin-1 and mPGES-1 was in endochylema. Significant differences in expression was noted among PCa, BPH and normal issues (P<0.05). Beclin-1 expression inversely correlated with mPGES-1 expression in PCa tissue (P<0.05). CAY10526 could significantly block mPGES-1 expression and the proliferation of DU-145 cells (P<0.05), while increasing Beclin-1 levels (P<0.05). Overexpression of mPGES-1 could decrease the autophagic PCa cell death. Inhibiting the expression of mPGES-1 may lead to DU-145 cell death and up-regulation of Beclin-1. The results suggest that inhibition of mPGES-1 may have therapeutic potential for PCa in the future.

Protein-protein Interaction Network Analyses for Elucidating the Roles of LOXL2-delta72 in Esophageal Squamous Cell Carcinoma

Wu, Bing-Li,Zou, Hai-Ying,Lv, Guo-Qing,Du, Ze-Peng,Wu, Jian-Yi,Zhang, Pi-Xian,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase (LOX) family, is a copper-dependent enzyme that catalyzes oxidative deamination of lysine residues on protein substrates. LOXL2 was found to be overexpressed in esophageal squamous cell carcinoma (ESCC) in our previous research. We later identified a LOXL2 splicing variant LOXL2-delta72 and we overexpressed LOXL2-delta72 and its wild type counterpart in ESCC cells following microarray analyses. First, the differentially expressed genes (DEGs) of LOXL2 and LOXL2-delta72 compared to empty plasmid were applied to generate protein-protein interaction (PPI) sub-networks. Comparison of these two sub-networks showed hundreds of different proteins. To reveal the potential specific roles of LOXL2- delta72 compared to its wild type, the DEGs of LOXL2-delta72 vs LOXL2 were also applied to construct a PPI sub-network which was annotated by Gene Ontology. The functional annotation map indicated the third PPI sub-network involved hundreds of GO terms, such as "cell cycle arrest", "G1/S transition of mitotic cell cycle", "interphase", "cell-matrix adhesion" and "cell-substrate adhesion", as well as significant "immunity" related terms, such as "innate immune response", "regulation of defense response" and "Toll signaling pathway". These results provide important clues for experimental identification of the specific biological roles and molecular mechanisms of LOXL2-delta72. This study also provided a work flow to test the different roles of a splicing variant with high-throughput data.

Interactions Between MTHFR C677T - A1298C Variants and Folic Acid Deficiency Affect Breast Cancer Risk in a Chinese Population

Wu, Xia-Yu,Ni, Juan,Xu, Wei-Jiang,Zhou, Tao,Wang, Xu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Background: Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer. Methods: Genetic damage was marked by micronucleated binucleated cells (MNBN) and apoptosis was estimated by cytokinesis-block micronucleus assay (CBMN). PCR-RFLP molecular analysis was carried out. Results: The results showed significant associations between the MTHFR 677TT or the combined MTHFR C677T-A1298C and breast cancer risk (OR = 2.51, CI = 0.85 to 7.37, p = 0.08; OR = 4.11, CI = 0.78 to 21.8, p < 0.001). The MNBN from the combined MTHFR C677T-A1298C was higher and the apoptosis was lower than that of the single variants (p < 0.05). At 15 to 60 nmol/L FA, the MNBN in cases with the TTAC genotype was higher than controls (p < 0.05), whereas no significant difference in apoptosis was found between the cases and controls after excluding the genetic background. Conclusions: Associations between the combined MTHFR C677T-A1298C polymorphism and breast cancer are possible from this study. A dose of 120 nmol/L FA could enhance apoptosis in cases with MTHFR C677T-A1298C. Breast cancer individuals with the TTAC genotype may be more sensitive to the genotoxic effects of FA deficiency than controls.