http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The ISDF Framework: Towards Secure Software Development
Alkussayer, Abdulaziz,Allen, William H. Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.1
The rapid growth of communication and globalization has changed the software engineering process. Security has become a crucial component of any software system. However, software developers often lack the knowledge and skills needed to develop secure software. Clearly, the creation of secure software requires more than simply mandating the use of a secure software development lifecycle; the components produced by each stage of the lifecycle must be correctly implemented for the resulting system to achieve its intended goals. This study demonstrates that a more effective approach to the development of secure software can result from the integration of carefully selected security patterns into appropriate stages of the software development lifecycle to ensure that security designs are correctly implemented. The goal of this study is to provide developers with an Integrated Security Development Framework (ISDF) that can assist them in building more secure software.
Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa
Tomita Yohei,Qiu Chenxi,Bull Edward,Allen William,Kotoda Yumi,Talukdar Saswata,Smith Lois E. H.,Fu Zhongjie 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Photoreceptor degeneration caused by genetic defects leads to retinitis pigmentosa, a rare disease typically diagnosed in adolescents and young adults. In most cases, rod loss occurs first, followed by cone loss as well as altered function in cells connected to photoreceptors directly or indirectly. There remains a gap in our understanding of retinal cellular responses to photoreceptor abnormalities. Here, we utilized single-cell transcriptomics to investigate cellular responses in each major retinal cell type in retinitis pigmentosa model (P23H) mice vs. wild-type littermate mice. We found a significant decrease in the expression of genes associated with phototransduction, the inner/outer segment, photoreceptor cell cilium, and photoreceptor development in both rod and cone clusters, in line with the structural changes seen with immunohistochemistry. Accompanying this loss was a significant decrease in the expression of genes involved in metabolic pathways and energy production in both rods and cones. We found that in the Müller glia/astrocyte cluster, there was a significant increase in gene expression in pathways involving photoreceptor maintenance, while concomitant decreases were observed in rods and cones. Additionally, the expression of genes involved in mitochondrial localization and transport was increased in the Müller glia/astrocyte cluster. The Müller glial compensatory increase in the expression of genes downregulated in photoreceptors suggests that Müller glia adapt their transcriptome to support photoreceptors and could be thought of as general therapeutic targets to protect against retinal degeneration.