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- 저자 : Wen-Xiao Chu (검색결과 4 건)
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Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats
Wen-Wen Yan,Li-Hua Yao,Chong Chen,Hai-Xia Wang,Chu-Hua Li,Jun-Ni Huang,Peng Xiao,Cheng-Yi Liu 대한배뇨장애요실금학회 2015 International Neurourology Journal Vol.19 No.4
Purpose: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded as a cognitive enhancer, the aim of this study was to investigate the effects of chronic modafinil administration on behavioral learning in healthy adult rats. Methods: Y-maze training was used to assess learning performance, and the whole-cell patch clamp technique was used to assess synaptic transmission in pyramidal neurons of the hippocampal CA1 region of rats. Results: Intraperitoneal administration of modafinil at 200 mg/kg or 300 mg/kg significantly improved learning performance. Furthermore, perfusion with 1mM modafinil enhanced the frequency and amplitude of spontaneous postsynaptic currents and spontaneous excitatory postsynaptic currents in CA1 pyramidal neurons in hippocampal slices. However, the frequency and amplitude of spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons were inhibited by treatment with 1mM modafinil. Conclusions: These results indicate that modafinil improves learning and memory in rats possibly by enhancing glutamatergic excitatory synaptic transmission and inhibiting GABAergic (gamma-aminobutyric acid-ergic) inhibitory synaptic transmission.
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Wen-Xiao Chu,Rui Wang,CHI-CHUAN WANG 대한설비공학회 2019 International Journal of Air-Conditioning and Refr Vol.27 No.4
This paper experimentally investigates the effect of pressure resistance distribution by using perforated grilles with different porosities (F=100%, 58% and 35.4%) in a container data center. The inlet and outlet temperature distribution, rack cooling index (RCI) and supply heat index (SHI) are used to evaluate the cooling performance under semi-contained and fully contained configurations. As a result, the airflow reversal phenomenon at the top cabinets is found, which is especially conspicuous for the case without perforated grilles due to the extremely low pressure resistance in the cabinet. By implementing perforated grilles at lower three cabinets, the airflow reversal can be eliminated, however, it cannot be completely removed. By applying perforated grilles with F=35.4% at the top three cabinets can increase the pressure resistance at the cabinets S1 where the airflow reversal is eliminated thoroughly. Yet, the performance of cabinets at rack A1 may degrade rapidly due to much stronger hot-exhaust recirculation. Hence, the fully contained configuration is applied. Note that the airflow reversal is more severe for the case without perforated grilles. By arranging the perforated grilles with F = 35.4%, the corresponding RCI and SHI may reach the ideal values of 100% and zero, respectively. Therefore, the perforated grilles with F= 35.4% are more reasonable for simulated racks under semi-contained and fully contained configurations when airflow reversal occurs.
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Bao-yong Lai,Li-yan Jia,Bo-Wen Yu,Shi-Bing Liang,Ai-Jing Chu,Hui-juan Cao,Jian-ping Liu,Xiao-Hua Pei 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2
Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eff ;ectiveness and safety of RPSJ capsule for breast pain. Methods: We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results: Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions: RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials.
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Xu, Sheng,Yan, Zheng,Jang, Kyung-In,Huang, Wen,Fu, Haoran,Kim, Jeonghyun,Wei, Zijun,Flavin, Matthew,McCracken, Joselle,Wang, Renhan,Badea, Adina,Liu, Yuhao,Xiao, Dongqing,Zhou, Guoyan,Lee, Jungwoo,Chu American Association for the Advancement of Scienc 2015 Science Vol.347 No.6218
<P><B>Popping materials and devices from 2D into 3D</B></P><P>Curved, thin, flexible complex three-dimensional (3D) structures can be very hard to manufacture at small length scales. Xu <I>et al.</I> develop an ingenious design strategy for the microfabrication of complex geometric 3D mesostructures that derive from the out-of-plane buckling of an originally planar structural layout (see the Perspective by Ye and Tsukruk). Finite element analysis of the mechanics makes it possible to design the two 2D patterns, which is then attached to a previously strained substrate at a number of points. Relaxing of the substrate causes the patterned material to bend and buckle, leading to its 3D shape.</P><P><I>Science</I>, this issue p. 154; see also p. 130</P><P>Complex three-dimensional (3D) structures in biology (e.g., cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life. Compelling opportunities exist for analogous 3D architectures in human-made devices, but design options are constrained by existing capabilities in materials growth and assembly. We report routes to previously inaccessible classes of 3D constructs in advanced materials, including device-grade silicon. The schemes involve geometric transformation of 2D micro/nanostructures into extended 3D layouts by compressive buckling. Demonstrations include experimental and theoretical studies of more than 40 representative geometries, from single and multiple helices, toroids, and conical spirals to structures that resemble spherical baskets, cuboid cages, starbursts, flowers, scaffolds, fences, and frameworks, each with single- and/or multiple-level configurations.</P>
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