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- 저자 : Weiliang Lin (검색결과 6 건)
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Simulation of Grid-Connected Solar Micro-inverter Based on Fuzzy PI Controller
Weiliang Liu,Changliang Liu,Huichao Zhang,Yongjun Lin,Liangyu Ma 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10
Grid-connected solar micro-inverter is a highly nonlinear and time-varying system, so it is difficult to achieve good control effect using traditional PI controller. In this paper, small signal analysis model of micro-inverter is established, grid-connected current control strategy composed of fuzzy PI controller and grid voltage feed-forward is put forward, and the initial parameters of PI controller is optimized using the genetic algorithm. Simulation results show that the control strategy has the virtues of good robustness, small dynamic deviation, and could reduce the harmonic content of grid-connected current.
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Vitellogenin’s putative role in Tegillarca granosa’s cadmium detoxification
Caifang Chen,Weiliang Shen,Hailong Gu,Linde Wu,Zhihua Lin,Qinggang Xue 한국유전학회 2017 Genes & Genomics Vol.39 No.2
The bloody clam, Tegillarca granosa, is a commercial benthic bivalve, having a strong accumulation ability and torrelence to cadmium. To investigate whether vitellogenin (Vg) is involved in cadmium (Cd) detoxification, the full-length cDNA of T. granosa Vg was cloned, and its expression pattern in response to cadmium exposure was studied compared with the reference metallothionein (MT) gene. The full T. granosa Vg sequence consisted of 8988 bp, including a 6930-bp open reading frame that encoded a 2309 amino acid polypeptide. The deduced Vg protein contained a Vg N-terminal domain, domain of unknown function (DUF1943), SbcC domain, and von Willebrand factor typeD domain (VWD). Multiple metal-binding sites were predicted in the deduced T. granosaVg protein, suggesting its potential in functioning as a metal-binding protein. In addition, Vg expression increased in the T. granosa digestive gland and hemolymph in time-dependent manner after exposure to 1, 3, 6 and 9 lg/L Cd for 28 days.MTexpression was measured in parallel with Vg expression, and the latter was more sensitive to Cd induction than the former. Together, results of the present research suggested that Vg may play an important role in T. granosa metal detoxification.
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Defense responses of sulfur dioxygenase to sulfide stress in the razor clam Sinonovacula constricta
Caifang Chen,Yaoyao Shen,Weiliang Shen,Jing He,Zhihua Lin,Yinghui Dong 한국유전학회 2021 Genes & Genomics Vol.43 No.5
Background Sulfde is a well-known toxicant widely distributed in the culture environment. As a representative burrowing benthic bivalve, the razor clam Sinonovacula constricta is highly sulfde tolerant. Mitochondrial sulfde oxidation is an important way for sulfde detoxifcation, where sulfur dioxygenase (SDO) is the second key enzyme. Objective To investigate the mechanism of sulfde tolerance in S. constricta, the molecular characterization of its SDO (designated as ScSDO) was studied. Methods The cDNA sequence of ScSDO was cloned by RACE technique. The response of ScSDO in gills and livers of S. constricta was investigated during sulfde exposure (50, 150, and 300 μM sulfde) for 0, 3, 6, 12, 24, 48, 72, and 96 h by qRTPCR. Moreover, the temporal expression of ScSDO protein in S. constricta gills after exposure to 150 μM sulfde was detected by Western blot. The subcellular location of ScSDO was identifed by TargetP 1.1 prediction and Western Blot analysis. Results The full-length cDNA of ScSDO was 2914 bp, encoding a protein of 304 amino acids. The deduced ScSDO protein was highly conserved, containing the signature HXHXDH motif of the metallo-β-lactamase superfamily and two metalbinding sites, of which metal-binding site I is known to be the catalytically active center. Subcellular localization confrmed that ScSDO was located only in the mitochondria. Responding to the sulfde exposure, distinct time-dependent increases in ScSDO expression were detected at both mRNA and protein levels. Moreover, the gills exhibited a higher ScSDO expression level than the livers. Conclusions All of our results suggest that ScSDO plays an important role in mitochondrial sulfde oxidation during sulfde stress, making S. constricta highly sulfde tolerant. In addition, as a respiratory tissue, the gills play a more critical role in sulfde detoxifcation.
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SRRS Effects on ICF Laser Drive Beam with the Variation of Pump Light Distribution on Space
Ying Liu,Dianyang Lin,Zhiwei Lu,Weiliang Zeng 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.6
Tens to hundreds of output high power lasers from ICF (inertial confinement fusion) device, generally need to propagate through a long air path before they reach the target chamber. During the process, interaction between the high power pulse laser and air molecules emerges. Once the SRRS (stimulated rotational Raman scattering) threshold was reached, the SRRS effect would result in the loss of laser energy, the decrease of laser beam quality, or unable to reach the target. Further the transmitted laser would enter the multipliers as fundamental beam, then the conversion efficiency of triple-harmonic would be affected, even cause the destroy of frequency multiplication crystal. In order to improve the output ability, beam quality and control ability of the ICF high power laser drive, ultimately achieve the fusion ignition success, the SRRS effect must be suppressed. Based on SRRS four-dimensional mathematical model which conforms to current ICF experiment conditions, the longitudinal and horizontal rules of SRRS effect on ICF laser drive beam with the variation of pump light distribution on space was obtained. The research provided a support for the parameters choice of ICF laser drive and the optimization of output beam quality.
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Feng, Enguang,Shin, Woo-Jin,Zhu, Xuelian,Li, Jian,Ye, Deju,Wang, Jiang,Zheng, Mingyue,Zuo, Jian-Ping,No, Kyoung Tai,Liu, Xian,Zhu, Weiliang,Tang, Wei,Seong, Baik-Lin,Jiang, Hualiang,Liu, Hong American Chemical Society 2013 Journal of medicinal chemistry Vol.56 No.3
<P>In order to exploit the 430-cavity in the active sites of neuraminidases, 22 zanamivir analogs with C-1 and C-4 modification were synthesized, and their inhibitory activities against both group-1 (H5N1, H1N1) and group-2 neuraminidases (H3N2) were determined. Compound <B>9f</B> exerts the most potency, with IC<SUB>50</SUB> value of 0.013, 0.001, and 0.09 μM against H3N2, H5N1, and H1N1, which is similar to that of zanamivir (H3N2 IC<SUB>50</SUB> = 0.0014 μM, H5N1 IC<SUB>50</SUB> = 0.012 μM, H1N1 IC<SUB>50</SUB> = 0.001 μM). Pharmacokinetic studies of compound <B>9f</B> in rats showed a much longer plasma half-life (<I>t</I><SUB>1/2</SUB>) than that of zanamivir following administration (po dose). Molecular modeling provided information about the binding model between the new inhibitors and neuraminidase, with the elongated groups at the C-1-position being projected toward the 430-loop region. This study may represent a novel starting point for the future development of improved antiflu agents.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2013/jmcmar.2013.56.issue-3/jm3009713/production/images/medium/jm-2012-009713_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3009713'>ACS Electronic Supporting Info</A></P>
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