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Bolted end plate connections for steel reinforced concrete composite structures
Li, Xian,Wu, Yuntian,Mao, Weifeng,Xiao, Yan,Anderson, J.C.,Guo, Yurong Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.3
In order to improve the constructability and meanwhile ensure excellent seismic behavior, several innovative composite connection details were conceived and studied by the authors. This paper reports experimental results and observations on seismic behavior of steel beam bolted to reinforced concrete column connections (bolted RCS or BRCS). The proposed composite connection details involve post tensioning the end plates of the steel beams to the reinforced concrete or precast concrete columns using high-strength steel rods. A rational design procedure was proposed to assure a ductile behavior of the composite structure. Strut-and-tie model analysis indicates that a bolted composite connection has a favorable stress transfer mechanism. The excellent capacity and behavior were then validated through five full-scale beam to column connection model tests.
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Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells
Jun Pei,Baohui Han,Tianqing Chu,Minhua Shao,Jiajun Teng,Huifang Sha,Aiqing Gu,Rong Li,Jialin Qian,Weifeng Mao,Ying Li 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.3
Purpose: c-Met and its ligand, hepatocyte growth factor (HGF), play a critical role in oncogenesis and metastatic progression. The aim of this study was to identify inhibited enzymogram and to test the antitumor activity of SIM-89 (a c-Met receptor tyrosine kinaseinhibitor) in non-small cell lung cancer. Materials and Methods: Z’-LYTE kinase assay was employed to screen the kinase enzymogram, and mechanism of action (MOA) analysis was used to identify the inhibited kinases. Cell proliferation was then analyzed by CCK8 assay, and cell migration was determinedby transwell assay. The gene expression and the phosphorylation of c-Met were examined by realtime-PCR and western blotting, respectively. Finally, the secretion of HGF was detected by ELISA assay. Results: c-Met, activated protein kinase (AMPK), and tyrosine kinase A (TRKA) were inhibited by SIM-89 with the IC50 values of 297 nmol/L, 1.31 μmol/L, and 150.2 nmol/L, respectively. SIM-89 exerted adenosine triphosphate (ATP) competitive inhibition on c-Met. Moreover, the expressions of STAT1, JAK1, and c-Met in H460 cells were decreased by SIM-89 treatment, and c-Met phosphorylationwas suppressed in A549, H441, H1299, and B16F10 cells by the treatment. In addition, SIM-89 treatment significantly decreased the level of HGF, which accounted for the activation of c-Met receptor tyrosine kinase. Finally, we showed cell proliferationinhibition and cell migration suppression in H460 and H1299 cells after SIM-89 treatment. Conclusion: In conclusion, SIM-89 inhibits tumor cell proliferation, migration and HGF autocrine, suggesting it’s potential antitumoractivity.
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