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RISS 인기검색어
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- 저자 : WeiLin Dong (검색결과 5 건)
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Weilin Chen,Chunning Ji,Md. Mahbub Alam,Dong Xu 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.1
Vortex-induced vibration of three circular cylinders (each of diameter D) in an equilateral triangular arrangement is investigated using the immersed boundary method. The cylinders, with one placed upstream and the other two side-by-side downstream, are free to vibrate in the cross-flow direction. The cylinder center-to-center spacing L is adopted as L/D = 2.0. Other parameters include the Reynolds number Re = 100, mass ratio m* = 2.0, reduced velocity Ur = 2 ~ 15 and damping ratio = 0. Cylinder vibration responses are dependent on Ur and classified into five regimes, i.e. Regime I (Ur ≤ 3.2), Regime II (3.2 < Ur ≤ 5.0), Regime III (5.0 < Ur ≤ 6.4), Regime IV (6.4 < Ur ≤ 9.2) and Regime V (Ur > 9.2). Different facets of vibration amplitude, hydrodynamic forces, wake patterns and displacement spectra are extracted and presented in detail for each regime.
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Optical Super-Resolution Imaging of Surface Reactions
Chen, Tao,Dong, Bin,Chen, Kuangcai,Zhao, Fei,Cheng, Xiaodong,Ma, Changbei,Lee, Seungah,Zhang, Peng,Kang, Seong Ho,Ha, Ji Won,Xu, Weilin,Fang, Ning American Chemical Society 2017 Chemical reviews Vol.117 No.11
<P>Optical super-resolution imaging has gained momentum in investigations of heterogeneous and homogeneous chemical reactions at the single-molecule level. Thanks to its exceptional spatial resolution and ability to monitor dynamic systems, much detailed information on single-molecule reaction/adsorption processes and single-particle catalytic processes has been revealed, including chemical kinetics and reaction dynamics; active-site distributions on single-particle surfaces; and size-, shape-, and facet-dependent catalytic activities of individual nanocatalysts. In this review, we provide an overview of recent advances in super-resolution chemical imaging of surface reactions.</P>
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LiQin Zhu,JianWei Yang,Yuan Zhang,YongMing Wang,JianLei Zhang,YuanYuan Zhao,WeiLin Dong 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intraabdominalinfected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profilesin various tissues in intra-abdominal infected human. 12 male rats with intra- abdominal infections,induced by Escherichia coli, received a single dose of 40 mg/kg body weight of moxifloxacin. Bloodplasma was collected at 5, 10, 20, 30, 60, 120, 240, 480, 1440 min after drug injection. A PBPK modelwas developed in rats and extrapolated to human using GastroPlus software. The predictions wereassessed by comparing predictions and observations. In the plasma concentration versus time profileof moxifloxcinin rats, Cmax was 11.151 μg/mL at 5 min after the intravenous injection and t1/2 was2.936 h. Plasma concentration and kinetics in human were predicted and compared with observed datas. Moxifloxacin penetrated and accumulated with high concentrations in redmarrow, lung, skin, heart,liver, kidney, spleen, muscle tissues in human with intra-abdominal infection. The predicted tissue toplasma concentration ratios in abdominal viscera were between 1.1 and 2.2. When rat plasma concentrationswere known, extrapolation of a PBPK model was a method to predict drug pharmacokineticsand penetration in human. Moxifloxacin has a good penetration into liver, kidney, spleen, as well asother tissues in intra-abdominal infected human. Close monitoring are necessary when using moxifloxacindue to its high concentration distribution. This pathological model extrapolation may provide referenceto the PK/PD study of antibacterial agents.
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Vortex-induced vibration of a long flexible cylinder in uniform cross-flow
Ji, Chunning,Peng, Ziteng,Alam, Md. Mahbub,Chen, Weilin,Xu, Dong Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.26 No.5
Numerical simulations are performed of a long flexible cylinder undergoing vortex-induced vibration at a Reynolds number of 500. The cylinder is pinned at both ends, having an aspect ratio of 100 (cylinder length to cylinder diameter) and a mass ratio of 4.2 (structural mass to displaced fluid mass). Temporal and spatial information on the cross-flow (CF) and in-line (IL) vibrations is extracted. High modal vibrations up to the $6^{th}$ in the CF direction and the $11^{th}$ in the IL direction are observed. Both the CF and IL vibrations feature a multi-mode mixed pattern. Mode competition is observed. The $2^{nd}$ mode with a low frequency dominates the IL vibration and its existence is attributed to a wave group propagating back and forth along the span. Distributions of fluid force coefficients are correlated to those of the CF and IL vibrations along the span. Histograms of the x'-y motion phase difference are evaluated from the total simulation time and a complete vibration cycle representing the standing or travelling wave pattern. Correlations between the phase difference and the vibrations are discussed. Vortex structures behind the cylinder show an interwoven near-wake pattern when the standing wave pattern dominates, but an oblique near-wake pattern when the travelling wave pattern prevails.
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Zhu, LiQin,Yang, JianWei,Zhang, Yuan,Wang, YongMing,Zhang, JianLei,Zhao, YuanYuan,Dong, WeiLin The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intra-abdominal infected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profiles in various tissues in intra-abdominal infected human. 12 male rats with intra- abdominal infections, induced by Escherichia coli, received a single dose of 40 mg/kg body weight of moxifloxacin. Blood plasma was collected at 5, 10, 20, 30, 60, 120, 240, 480, 1440 min after drug injection. A PBPK model was developed in rats and extrapolated to human using GastroPlus software. The predictions were assessed by comparing predictions and observations. In the plasma concentration versus time profile of moxifloxcinin rats, $C_{max}$ was $11.151{\mu}g/mL$ at 5 min after the intravenous injection and $t_{1/2}$ was 2.936 h. Plasma concentration and kinetics in human were predicted and compared with observed datas. Moxifloxacin penetrated and accumulated with high concentrations in redmarrow, lung, skin, heart, liver, kidney, spleen, muscle tissues in human with intra-abdominal infection. The predicted tissue to plasma concentration ratios in abdominal viscera were between 1.1 and 2.2. When rat plasma concentrations were known, extrapolation of a PBPK model was a method to predict drug pharmacokinetics and penetration in human. Moxifloxacin has a good penetration into liver, kidney, spleen, as well as other tissues in intra-abdominal infected human. Close monitoring are necessary when using moxifloxacin due to its high concentration distribution. This pathological model extrapolation may provide reference to the PK/PD study of antibacterial agents.
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