http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Wei-Nan Kang (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
-
Wei-Nan Kang,Yang Zeng,Dao-Hong Zhu 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.2
Fighting commonly occurs among animals and is very important for resolving conflicts between conspecific individuals over limited resources. The plasticity of fighting strategies and neurobiological mechanisms underlying fighting behavior of insects are not fully understood. In the present study, we examined whether physical and social experiences affected the aggressiveness of males of the cricket Velarifictorus aspersus Walker, and whether an octopamine (OA) receptor agonist could affected the aggressiveness of males exposed to different experiences. We found that flight and winning a fight significantly enhanced male aggressiveness, while losing a fight significantly suppressed male aggressiveness, consistent with the findings of existing studies on other cricket species. We also found that female presence had a stronger enhancing effect on male aggressiveness than flight or winning a fight. These findings demonstrated that physical and social experiences can affect the fighting behavior of male V. aspersus. Topical application of a 0.15M solution of an OA receptor agonist (chlordimeform, CDM) significantly increased male aggression level, suggesting that OA may play an important role as a neuromodulator in controlling fighting behavior of males of this species. Despite displaying a significantly higher aggression level (level 5 or 6), CDM-treated losers did not escalate to physical combat, while fights between courting males usually resulted in physical escalation. It is likely that fighting behavior is only partly regulated by OA, and additional regulatory pathways may be involved in achieving physical combat.
-
Nan Shi,Hongwei Xu,Kaiyuan Guo,Chunyu Kang,Wei Zhang,Yingying Zhang,Liping Zhang,Jianxin Tan 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.8
Partitioning of microbial transglutaminase (MTG) from Amycolatopsis sp. in the polyethylene glycol (PEG)/salt-based ATPS was investigated for the first time. The key parameters such as the molecular weight of PEG (PEG 600-6000), the type and concentration of phase-forming salt (ammonium sulfate or phosphates), the pH of system (pH 5.0-8.5), and the concentration of neutral salt (0-6% NaCl, w/w) were determined. The partition coefficient of the enzyme was not linear with PEG molecular weight; PEG1000 gave better yield than others. The concentration of PEG1000, ammonium sulfate and NaCl, and the system pH showed effects with different extents on specific activity (SA) and yield of the enzyme. In the ATPS of 26% w/w PEG 1000 and 19% w/w ammonium sulfate in the presence of 5% w/w NaCl and at pH 6.0, MTG was partitioned into the PEG-rich phase with a maximum yield of 86.51% and SA was increased to 0.83. The results of SDS-PAGE showed the MTG produced by the test strain differed from the enzymes reported before. Thus, this study proves that ATPS can be used as a preliminary step for partial purification of MTG from Amycolatopsis sp. fermentation broth.
-
Coumarins and Lignans from Zanthoxylum schinifolium and Their Anticancer Activities
Li, Wei,Sun, Ya Nan,Yan, Xi Tao,Yang, Seo Young,Kim, Eun-Ji,Kang, Hee Kyoung,Kim, Young Ho American Chemical Society 2013 Journal of agricultural and food chemistry Vol.61 No.45
<P>Zanthoxylum schinifolium is an aromatic shrub, and its pericarp and leaves are widely used in culinary applications in East Asian countries. It has also long been used in traditional Oriental medicine for treating the common cold, stomach ache, diarrhea, and jaundice. In this study, we identified two new compounds, zanthoxyloside (<B>1</B>) and schinifolisatin A (<B>13</B>), along with 23 known coumarins (<B>2</B>–<B>12</B>) and lignans (<B>14</B>–<B>25</B>), from a methanol extract of the stems of Z. schinifolium. The chemical structures of the compounds were determined by mass, 1D-, and 2D NMR spectroscopy. The anticancer effects of the isolated compounds were examined in three human cancer cell lines. Compounds <B>10</B>–<B>12</B> significantly reduced the proliferation of HL-60 human acute promyelocytic leukemia cells with IC<SUB>50</SUB> values of 4.62–5.12 μM. Treatment of PC-3 prostate cancer cells and SNU-C5 colorectal cancer cells with compound <B>10</B> resulted in potent antiproliferative activity, with IC<SUB>50</SUB> values of 4.39 and 6.26 μM, respectively. Also, compounds <B>10</B>–<B>12</B> induced the apoptosis of three cancer cells. Furthermore, the induction of apoptosis was accompanied by down-regulation of p-ERK1/2 MAPK, p-AKT, and c-myc levels, in a time-dependent manner. These data suggested that compounds <B>10</B>–<B>12</B> from Z. schinifolium have potential in cancer treatment.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2013/jafcau.2013.61.issue-45/jf403479c/production/images/medium/jf-2013-03479c_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf403479c'>ACS Electronic Supporting Info</A></P>
-
-
-
Chemical Components from <i>Aloe</i> and their Inhibition of Indoleamine 2, 3-dioxygenase
Sun, Ya Nan,Li, Lin Ying,Li, Wei,Kang, Jong Seong,Hwang, Inkyu,Kim, Young Ho Medknow PublicationsMedia Pvt Ltd 2017 Pharmacognosy magazine Vol.13 No.49
<P><B>Background:</B></P><P>In Korea, <I>Aloe</I> is routinely ingested as a traditional medicine or as a component of health beverages.</P><P><B>Objective:</B></P><P>To research the inhibition of indoleamine 2, 3-dioxygenase (IDO) activities of components from <I>Aloe</I>.</P><P><B>Materials and Methods:</B></P><P>the compounds were isolated by a combination of silica gel and YMC Rp-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-NMR, and MS). All of the isolated compounds were examined for their ability to inhibit IDO, which actively suppresses immune functions by catalyzing the rate limiting reaction in the conversion of tryptophan to kynurenine.</P><P><B>Results:</B></P><P>In this phytochemical study, 18 known compounds were isolated from aqueous dissolved <I>Aloe</I> exudates. All of the isolated compounds were examined for their ability to inhibit IDO activities for a series of anthraquinone derivatives (1-7) isolated from the <I>Aloe</I> extract; the IC<SUB>50</SUB> values of these compounds ranged from 39.41 to 53.93 µM. Enzyme kinetic studies of their modes of inhibition indicated that all of the compounds were uncompetitive inhibitors.</P><P><B>Conclusion:</B></P><P>The aqueous dissolved <I>Aloe</I> exudate can be used as a source of novel natural IDO inhibitors and merit testing as therapeutic agents in the treatments of cancer and immunopathologic diseases, such as autoimmune, inflammatory, and allergic disorders.</P><P><B>SUMMARY</B></P><P><P>In this study, 18 known compounds were isolated from aqueous dissolved Aloe exudates. All of the isolated compounds were examined for their ability to inhibit indoleamine 2, 3-dioxygenase (IDO) activities for a series of anthraquinone derivatives (1−7) isolated from the Aloe extract.</P></P> >[FIG OMISSION]</BR><P><B>Abbreviation used:</B> IDO: inhibit indoleamine 2, 3-dioxygenase, TMS: tetramethylsilane, HMQC: heteronuclear multiple quantum correlation, HMBC: heteronuclear multiple bond correlation, COSY: 1H-1H correlation spectroscopy, ESI-MS: Electrospray ionization mass spectrometry, DMSO: dimethyl sulfoxide</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
